Translation, cross-cultural adaptation and applicability of the Brazilian version of the frontotemporal dementia rating scale (FTD-FRS)
Open accessAbstract
BACKGROUND: Staging scales for dementia have been devised for grading Alzheimer's disease (AD) but do not include the specific symptoms of frontotemporal lobar degeneration (FTLD). OBJECTIVE: To translate and adapt the Frontotemporal Dementia Rating Scale (FTD-FRS) to Brazilian Portuguese. METHODS: The cross-cultural adaptation process consisted of the following steps: translation, back-translation (prepared by independent translators), discussion with specialists, and development of a final version after minor adjustments. A pilot application was carried out with 12 patients diagnosed with bvFTD and 11 with AD, matched for disease severity (CDR=1.0). The evaluation protocol included: Addenbrooke's Cognitive Examination-Revised (ACE-R), Mini-Mental State Examination (MMSE), Executive Interview (EXIT-25), Neuropsychiatric Inventory (NPI), Frontotemporal Dementia Rating Scale (FTD-FRS) and Clinical Dementia Rating scale (CDR). RESULTS: The Brazilian version of the FTD-FRS seemed appropriate for use in this country. Preliminary results revealed greater levels of disability in bvFTD than in AD patients (bvFTD: 25% mild, 50% moderate and 25% severe; AD: 36.36% mild, 63.64% moderate). It appears that the CDR underrates disease severity in bvFTD since a relevant proportion of patients rated as having mild dementia (CDR=1.0) in fact had moderate or severe levels of disability according to the FTD-FRS. CONCLUSION: The Brazilian version of the FTD-FRS seems suitable to aid staging and determining disease progression.
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The FRS is a well-established dementia staging tool in frontotemporal dementia and has been validated in Alzheimer's disease with superior ability to stage dementia than the Clinical Dementia Rating Scale.
“The scale is a well-established dementia staging tool in frontotemporal dementia and has been validated in Alzheimer's disease with superior ability to stage dementia than the Clinical Dementia Rating Scale (Lima-Silva et al., 2013).”
From Exploring the impact of carer stressors and psychological inflexibility on depression and anxiety in family carers of people with dementia (2020) · cites this paper as Lima-Silva et al., 2013
The Introduction describes the FTD-FRS as a tool for staging frontotemporal dementia, and the Discussion reports that it detected moderate severity in 64% of patients with Alzheimer’s disease whom the CDR classified as mild. But the Discussion calls these results preliminary and says further psychometric study is needed; it does not establish validation in Alzheimer’s disease or overall superiority to the CDR. (LLM, conf=0.86)
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- Authors
- Lima-Silva, T. B., Bahia, V. S., Carvalho, V. A., Guimarães, H. C., Caramelli, P., Balthazar, M., Damasceno, B., Bottino, C. M. D. C., Brucki, S. M. D., Mioshi, E., Nitrini, R., & Yassuda, M. S.
- Affiliations
- University of São Paulo, Brazil
- Universidade de São Paulo (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Neuroscience Research Australia (AU)
- Corresponding author
- Yassuda, Mônica Sanches
- ORCID
- Venue
- Dementia & Neuropsychologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2013-12
- Volume
- 7
- Issue
- 4
- Pages
- 387-396
- ISSN
- 1980-5764 (ISSN-L)
- PMC
- PMC5619500
- OpenAlex
- W2101591602
- Cited by
- 19
- References
- 29
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2018: 4 · 2015: 1 · 2014: 2
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Dementia & Neuropsychologia (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- frontotemporal lobar degeneration, behavioral variant frontotemporal dementia, Alzheimer's disease, cross-cultural adaptation, Brazilian Portuguese translation, disease staging, disease progression, disability assessment, Clinical Dementia Rating, neuropsychiatric symptoms
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