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Cited by 612

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic Factors

Open access
Ghebeh, Hazem, Mohammed, Shamayel, Al-Omair, Abeer, Qattant, Amal, Lehe, Cynthia, Al-Qudaihi, Ghofran, Elkum, Naser, Alshabanah, Mohamed, Bin Amer, Suad, Tulbah, Asma, Ajarim, Dahish, Al-Tweigeri, Taher, Dermime, Said·2006·Neoplasia
DOI 10.1593/neo.05733
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Abstract

B7-H1 molecule increases the apoptosis of tumor-reactive T lymphocytes and reduces their immunogenicity. Breast cancer is the second most common cause of mortality after lung cancer. Direct evidence linking B7-H1 with cancer has been shown in several malignancies; however, its expression in breast cancer has not been investigated. We used immunohistochemistry to investigate the expression of the B7-H1 molecule in 44 breast cancer specimens and to study its correlation with patients' clinicopathological parameters. The expression of B7-H1 was shown in 22 of 44 patients and was not restricted to the tumor epithelium (15 of 44, 34% in tumor cells), but was also expressed by tumor-infiltrating lymphocytes (TIL; 18 of 44, 41%). Interestingly, intratumor expression of B7-H1 was significantly associated with histologic grade III-negative (P = .012), estrogen receptor-negative (P = .036), and progesterone receptor-negative (P = .040) patients. In addition, the expression of B7-H1 in TIL was associated with large tumor size (P = .042), histologic grade III (P = .015), positivity of Her2/neu status (P = .019), and severe tumor lymphocyte infiltration (P = .001). Taken together, these data suggest that B7-H1 may be an important risk factor in breast cancer patients and may represent a potential immunotherapeutic target using monoclonal antibody against the B7-H1 molecule.

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Metadata

Authors
Ghebeh, H., Mohammed, S., Al-Omair, A., Qattant, A., Lehe, C., Al-Qudaihi, G., Elkum, N., Alshabanah, M., Bin Amer, S., Tulbah, A., Ajarim, D., Al-Tweigeri, T., & Dermime, S.
Venue
Neoplasia
Publisher
Elsevier BV
Published
2006-03
Volume
8
Issue
3
Pages
190-198
ISSN
1476-5586 (ISSN-L)
DOI
10.1593/neo.05733
OpenAlex
W1994238092
Cited by
612
References
6
FWCI
5.43
Type
journal article
Language
en
Open access
gold

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