The DOI matches its Crossref record; 195 of the 195 references it cites were found in a registry or an index.
On the Origin of Cancer Metastasis
Open accessAbstract
Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality. In order to complete the metastatic cascade, cancer cells must detach from the primary tumor, intravasate into the circulatory and lymphatic systems, evade immune attack, extravasate at distant capillary beds, and invade and proliferate in distant organs. Currently, several hypotheses have been advanced to explain the origin of cancer metastasis. These involve an epithelial mesenchymal transition, an accumulation of mutations in stem cells, a macrophage facilitation process, and a macrophage origin involving either transformation or fusion hybridization with neoplastic cells. Many of the properties of metastatic cancer cells are also seen in normal macrophages. A macrophage origin of metastasis can also explain the long-standing "seed and soil" hypothesis and the absence of metastasis in plant cancers. The view of metastasis as a macrophage metabolic disease can provide novel insight for therapeutic management.
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Cites
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Lin, Y., Xu, J., & Lan, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0760-3 · Cited by 1,398
The role of necroptosis in cancer biology and therapy
Gong, Y., Fan, Z., Luo, G., Yang, C., Huang, Q., Fan, K., Cheng, H., Jin, K., Ni, Q., Yu, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1029-8 · Cited by 1,040
Bui, T. M., Wiesolek, H. L., & Sumagin, R. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mr0220-549r · Cited by 957
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
Khalaf, K., Hana, D., Chou, J. T.-T., Singh, C., Mackiewicz, A., & Kaczmarek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656364 · Cited by 513
Insights into the role of sialylation in cancer progression and metastasis
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Metadata
- Authors
- Seyfried, T. N., & Huysentruyt, L. C.
- Venue
- Critical Reviews in Oncogenesis
- Publisher
- Begell House
- Published
- 2013
- Volume
- 18
- Issue
- 1 - 2
- Pages
- 43-73
- ISSN
- 0893-9675 (ISSN-L)
- OpenAlex
- W2000241906
- Cited by
- 1,196
- References
- 195
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
