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Cited by 39

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Growth Hormone–Induced Stimulation of Multilineage Human Hematopoiesis

Hanley, Mary B., Napolitano, Laura A., McCune, Joseph M.·2005·STEM CELLS
DOI 10.1634/stemcells.2004-0322
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Abstract

Growth hormone (GH) has been shown to have significant positive effects on hemato-lymphopoiesis in rodent models and, more recently, to increase thymic mass and circulating naïve CD4+ T cells in humans infected with the human immunodeficiency virus, type 1. To determine whether the latter effects on human T lymphopoiesis might be due, at least in part, to effects on the bone marrow (BM), we examined the specific effects of GH and its proximal mediator, insulin-like growth factor I (IGF-I), on human multilineage hematopoiesis in fetal BM (FBM). Using in vitro analysis, we found that GH and IGF-I each stimulated the expansion of primitive multilineage CD34+CD38- hematopoietic progenitor cells and increased yields of several hematopoietic subpopulations, including CD34+CD38+CD10+ lymphoid progenitor cells. Additionally, GH and IGF-I had direct effects on FBM stromal elements, inducing the expansion of myeloid-like CD45+CD14+ FBM stromal cells and enhancing production of the hematopoietic cytokine interleukin-3 by fibroblast-like CD45-CD10+ FBM stromal cells. Surface expression of GH and type-I IGF receptors correlated with the observed biologic responses to these hormones. Whereas GH enhanced the proliferation of FBM progenitors and stroma, IGF-I exerted a predominantly antiapoptotic effect. Finally, both GH and IGF-I stimulated the generation of hematopoietic colony forming cells. These findings identify specific targets of GH and IGF-I within human FBM, and demonstrate direct…

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Crossref · 10.1634/stemcells.2004-0322

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40 of 40 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 4

  1. 10.1210/endo.139.10.6263 · doi:10.1210/endo.139.10.6263 · Paper page
  2. 10.1016/0889-1591(92)90032-J · DOI
  3. Eaves C, 1995, Atlas of Human Hematopoietic Cells
  4. 10.1159/000184757 · DOI

Cited by

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Metadata

Authors
Hanley, M. B., Napolitano, L. A., & McCune, J. M.
Affiliations
Gladstone Institute of Virology and Immunology, San Francisco, California, USA
Venue
STEM CELLS
Publisher
Oxford University Press (OUP)
Published
2005-09
Volume
23
Issue
8
Pages
1170-1179
ISSN
  • 1066-5099
  • 1549-4918
DOI
10.1634/stemcells.2004-0322
Cited by
39
References
40
Language
en
Licence

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.