CXC chemokines located in the 4q21 region are up-regulated in breast cancer
Open accessAbstract
Recent data suggest that chemokines could be essential players in breast carcinogenesis. We previously showed that the CXC chemokine CXCL8 (interleukin-8) was overexpressed in estrogen receptor alpha (ERalpha)-negative breast cell lines. Analysis of CXCL8 chromosomal location showed that several CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL4V1, CXCL5, CXCL6, CXCL7, and CXCL8) were localized in the same narrow region (360 kb in size) of chromosome 4. We thus hypothesized that they could belong to the same cluster. Quantification of these chemokines in breast tumors showed that samples expressing high CXCL8 also produced elevated levels of CXCL1, CXCL3, and CXCL5, and displayed low content of ERalpha. CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8 were co-regulated both in tumors and in breast cancer cell lines. CXCL5 and CXCL8 were mainly produced by epithelial cells, whereas CXCL1, CXCL2, and CXCL3 had a high expression in blood cells. The overexpression of these chemokines in tumor cells was not the result of gene amplification, but rather of an enhanced gene transcription. Our data suggest that high CXCL8 expression in tumors is mainly correlated to activating protein-1 (AP-1) pathway and to a minor extent to NF-kappaB pathway. Interestingly, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 chemokines were present at higher levels in metastases when compared with grade I and III biopsies. High levels of CXCL8, CXCL1, and CXCL3 accounted for a shorter relapse-free survival of ERalpha-positive patients treated with tamoxifen. In summary, we present evidences that multiple CXC chemokines are co-expressed in CXCL8-positive breast tumors. In addition, these chemokines could account for the higher aggressiveness of these types of tumors.
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High expression of CXCL1 in breast tumors without gene amplification is also possible.
“Additionally, high expression of CXCL1 in breast tumors without gene amplification is also possible (Bieche et al., 2007).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Bieche et al., 2007
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Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856 · see citing works
On a Test of Whether one of Two Random Variables is Stochastically Larger than the Other
Mann, H. B., & Whitney, D. R. (1947) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177730491 · Cited by 14,320 · see citing works
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1977) · British Journal of Cancer · doi:10.1038/bjc.1977.1 · Cited by 8,285 · see citing works
Journal of the American Statistical Association
Koehler, A. B. (1995) · International Journal of Forecasting · doi:10.1016/0169-2070(95)90067-5 · Cited by 5,359 · see citing works
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340 · see citing works
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
Histological Grading and Prognosis in Breast Cancer
Bloom, H. J. G., & Richardson, W. (1957) · British Journal of Cancer · doi:10.1038/bjc.1957.43 · Cited by 2,938 · see citing works
The Biology of Chemokines and their Receptors
Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410 · see citing works
Cancer and the chemokine network
Balkwill, F. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1388 · Cited by 2,343 · see citing works
Arteriosclerosis, Thrombosis, and Vascular Biology
(2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0b013e31822a51e2 · Cited by 1,108 · see citing works
Chemokines: multiple levels of leukocyte migration control☆
Moser, B., Wolf, M., Walz, A., & Loetscher, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.12.005 · Cited by 859 · see citing works
Chemokine receptors: multifaceted therapeutic targets
Proudfoot, A. E. I. (2002) · Nature reviews. Immunology · doi:10.1038/nri722 · Cited by 755 · see citing works
The chemokine system: redundancy for robust outputs
Mantovani, A. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01469-3 · Cited by 703 · see citing works
Addison, C., Daniel, T. O., Burdick, M. D., Liu, H., Ehlert, J. E., Xue, Y., Buechi, L., Walz, A., Richmond, A. J., & Strieter, R. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.5269 · Cited by 578 · see citing works
Steroid hormone receptors in breast cancer management
Osborne, C. K. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006132427948 · Cited by 438 · see citing works
CXC chemokines in angiogenesis
Strieter, R. M., Burdick, M. D., Gomperts, B. N., Belperio, J. A., & Keane, M. P. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.007 · Cited by 416 · see citing works
ERβ Inhibits Proliferation and Invasion of Breast Cancer Cells
Lazennec, G., Bresson, D., Lucas, A., Chauveau, C., & Vignon, F. (2001) · Endocrinology · doi:10.1210/endo.142.9.8395 · Cited by 379 · see citing works
Self-citationHébert, C. A., Vitangcol, R. V., & Baker, J. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55160-7 · Cited by 375 · see citing works
Benoy, I. H., Salgado, R., van Dam, P. A., Geboers, K., Marck, E. V., Scharpé, S., Vermeulen, P. B., & Dirix, L. Y. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0812 · Cited by 356 · see citing works
Clark‐Lewis, I., Dewald, B., Geiser, T., Moser, B., & Baggiolini, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3574 · Cited by 258 · see citing works
Real-Time Reverse Transcription-PCR Assay for Future Management of ERBB2-based Clinical Applications
Bièche, I., Onody, P., Laurendeau, I., Olivi, M., Vidaud, D., Lidereau, R., & Vidaud, M. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.8.1148 · Cited by 254 · see citing works
Self-citationKozłowski, L., Zakrzewska, I., Tokajuk, P., & Wojtukiewicz, M. Z. (2003) · PubMed · Cited by 248 · see citing works
Salcedo, R., Resau, J. H., Halverson, D. O., Hudson, E. A., Dambach, M., Powell, D., Wasserman, K., & Oppenheim, J. J. (2000) · The FASEB Journal · doi:10.1096/fj.99-0963com · Cited by 244 · see citing works
THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS
Strieter, R. M., Polverini, P. J., Arenberg, D. A., & Kunkel, S. L. (1995) · Shock · doi:10.1097/00024382-199509000-00001 · Cited by 236 · see citing works
Freund, A., Chauveau, C., Brouillet, J., Lucas, A., Lacroix, M., Licznar, A., Vignon, F., & Lazennec, G. (2003) · Oncogene · doi:10.1038/sj.onc.1206113 · Cited by 225 · see citing works
Self-citationBendre, M. S., Gaddy-Kurten, D., Mon-Foote, T., Akel, N. S., Skinner, R. A., Nicholas, R. W., & Suva, L. J. (2002) · PubMed · Cited by 212 · see citing works
Lin, Y., Huang, R., Chen, L., Li, S., Shi, Q., Jordan, C., & Huang, R. (2004) · International Journal of Cancer · doi:10.1002/ijc.11724 · Cited by 205 · see citing works
Penson, R. T., Kronish, K., Duan, Z., Feller, A. J., Stark, P., Cook, S., Duska, L., Fuller, A. F., Goodman, A., Nikrui, N., et al. (2000) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.2000.00003.x · Cited by 192 · see citing works
Serum Interleukin 6, Plasma VEGF, Serum VEGF, and VEGF Platelet Load in Breast Cancer Patients
Benoy, I. H., Salgado, R., Colpaert, C., Weytjens, R., Vermeulen, P., & Dirix, L. Y. (2002) · Clinical Breast Cancer · doi:10.3816/cbc.2002.n.008 · Cited by 188 · see citing works
Yang, J., & Richmond, A. J. (2001) · PubMed · Cited by 182 · see citing works
Loukinova, E. B., Dong, G., Enamorado, I. I., Thomas, G. R., Chen, Z., Schreiber, H. W., & Waes, C. V. (2000) · Oncogene · doi:10.1038/sj.onc.1203687 · Cited by 172 · see citing works
Smadja, D. M., Bièche, I., Uzan, G., Bompais, H., Muller, L., Boisson‐Vidal, C., Vidaud, M., Aiach, M., & Gaussem, P. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184762.63888.bd · Cited by 133 · see citing works
Bièche, I., Parfait, B., Doussal, V. L., Olivi, M., Rio, M. C., Lidereau, R., & Vidaud, M. (2001) · PubMed · Cited by 133 · see citing works
Self-citationMechanisms underlying differential expression of interleukin-8 in breast cancer cells
Freund, A., Jolivel, V., Durand, S., Kersual, N., Chalbos, D., Carine Chavey, A., Vignon, F., & Lazennec, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207815 · Cited by 104 · see citing works
Self-citationGeneANOVA—gene expression analysis of variance
Didier, G., Brézellec, P., Rémy, É., & Hénaut, A. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.3.490 · Cited by 98 · see citing works
Short-term primary culture of epithelial cells derived from human breast tumours
Speirs, V., Green, A. R., Walton, D., Kerin, M. J., Fox, J. N., Carleton, P. J., Desai, S. B., & Atkin, S. L. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.702 · Cited by 95 · see citing works
Li, A., Varney, M. L., & Singh, R. K. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-004-5458-3 · Cited by 88 · see citing works
Wood, L. D., & Richmond, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30619 · Cited by 80 · see citing works
Larco, J. E. D., Wuertz, B. R. K., Manivel, J. C., & Furcht, L. T. (2001) · PubMed · Cited by 75 · see citing works
Ms, S., Garcia, M., Pujol, P., Fontana, J. A., & Rochefort, H. (1994) · PubMed · Cited by 75 · see citing works
Jiang, X. P., Yang, D. C., Elliott, R. L., & Head, J. F. (2000) · Cytokine · doi:10.1006/cyto.1999.0591 · Cited by 55 · see citing works
Mitogenic Effects of Interleukin-8/CXCL8 on Cancer Cells
Zhu, Y. M., & Woll, P. J. (2005) · Future Oncology · doi:10.2217/14796694.1.5.699 · Cited by 42 · see citing works
Skoog, L. K., Humla, S., Axelsson, M., Frost, M., Norman, A., Nordenskjöld, B. A., & Wallgren, A. (1987) · Acta Oncologica · doi:10.3109/02841868709091747 · Cited by 35 · see citing works
The Role of Chemokines in the Biology and Therapy of Breast Cancer
Walser, T. C., & Fulton, A. M. (2004) · Breast Disease · doi:10.3233/bd-2004-20114 · Cited by 27 · see citing works
Momma, T., Hamblin, M. R., & Hasan, T. G. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970917)72:6 · Cited by 20 · see citing works
Flagged first, then by citations
2 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P. G., Manova-Todorova, K., Leversha, M., Hogg, N., Seshan, V. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.042 · Cited by 1,085 · see citing works
Marotta, L. L. C., Almendro, V., Marusyk, A., Shipitsin, M. V., Schemme, J., Walker, S. R., Bloushtain-Qimron, N., Kim, J. J., Choudhury, S. A., Maruyama, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44745 · Cited by 913 · see citing works
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression
Sun, X., Cheng, G., Hao, M., Zheng, J., Zhou, X., Zhang, J., Taichman, R. S., Pienta, K. J., & Wang, J. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9256-x · Cited by 729 · see citing works
Chemokines and chemokine receptors: new insights into cancer-related inflammation
Lazennec, G., & Richmond, A. J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.01.003 · Cited by 651 · see citing works
Self-citationCXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
Kazanietz, M. G., Durando, M., & Cooke, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00471 · Cited by 351 · see citing works
A clinically relevant gene signature in triple negative and basal-like breast cancer
Rody, A., Karn, T., Liedtke, C., Pusztai, L., Ruckhaeberle, E., Hanker, L., Gaetje, R., Solbach, C., Ahr, A., Metzler, D., et al. (2011) · Breast Cancer Research · doi:10.1186/bcr3035 · Cited by 332 · see citing works
Tumor-associated neutrophils and neutrophil-targeted cancer therapies
Que, H., Fu, Q., Lan, T., Tian, X., & Wei, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188762 · Cited by 319 · see citing works
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Singh, J. K., Simões, B. M., Howell, S. J., Farnie, G., & Clarke, R. B. (2013) · Breast Cancer Research · doi:10.1186/bcr3436 · Cited by 250 · see citing works
CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target
Zhang, W., Wang, H., Sun, M., Deng, X., Wu, X., Ma, Y., Li, M., Shuoa, S. M., You, Q., & Miao, L. (2020) · 癌症：英文版 · doi:10.1002/cac2.12010 · Cited by 239 · see citing works
Gilbert, F. B., Cunha, P., Jensen, K., Glass, E. J., Foucras, G., Robert-Granié, C., Rupp, R., & Rainard, P. (2013) · Veterinary Research · doi:10.1186/1297-9716-44-40 · Cited by 231 · see citing works
Neutrophils: important contributors to tumor progression and metastasis
Swierczak, A., Mouchemore, K. A., Hamilton, J. A., & Anderson, R. L. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9594-9 · Cited by 220 · see citing works
A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-κB family
Vogel, C. F. A., & Matsumura, F. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.036 · Cited by 194 · see citing works
Estrogen receptor signaling as a target for novel breast cancer therapeutics
Renoir, J., Marsaud, V., & Lazennec, G. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.10.018 · Cited by 194 · see citing works
Self-citationChemokines: novel targets for breast cancer metastasis
Ali, S., & Lazennec, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9073-z · Cited by 178 · see citing works
Self-citationChen, J., & Russo, J. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.06.003 · Cited by 153 · see citing works
Hsu, Y.-L., Hou, M.-F., Kuo, P.-L., Huang, Y.-F., & Tsai, E.-M. (2012) · Oncogene · doi:10.1038/onc.2012.444 · Cited by 137 · see citing works
The Role of the Calcium-Sensing Receptor in the Development and Progression of Cancer
Saidak, Z., Mentaverri, R., & Brown, E. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0041 · Cited by 132 · see citing works
Harnessing the chemokine system to home CAR-T cells into solid tumors
Foeng, J., Comerford, I., & McColl, S. R. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100543 · Cited by 127 · see citing works
Tjomsland, V., Spångéus, A., Välilä, J., Sandström, P., Borch, K., Druid, H., Falkmer, S. E., Falkmer, S., Messmer, D., & Larsson, M. (2011) · Neoplasia · doi:10.1593/neo.11332 · Cited by 122 · see citing works
Wang, Y., Liu, J., Jiang, Q., Deng, J. V., Xu, F., Chen, X., Cheng, F., Zhang, Y., Yao, Y., Xia, Z., et al. (2017) · Stem Cells · doi:10.1002/stem.2643 · Cited by 119 · see citing works
Doll, D., Keller, L., Maak, M., Boulesteix, A., Siewert, J. R., Holzmann, B., & Janssen, K. (2010) · International Journal of Colorectal Disease · doi:10.1007/s00384-010-0901-1 · Cited by 107 · see citing works
CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer
Wang, B., Wang, M., Ao, D., & Wei, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188799 · Cited by 101 · see citing works
CXCR2 chemokine receptor – a master regulator in cancer and physiology
Lazennec, G., Rajarathnam, K., & Richmond, A. J. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.09.003 · Cited by 98 · see citing works
Self-citationCytokine Regulation of Metastasis and Tumorigenicity
Yao, M., Brummer, G., Acevedo, D. S., & Cheng, N. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.05.005 · Cited by 96 · see citing works
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands
SenGupta, S., Hein, L. E., Xu, Y., Zhang, J., Konwerski, J. R., Li, Y., Johnson, C. N., Cai, D., Smith, J. L., & Parent, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659996 · Cited by 93 · see citing works
Karn, T., Pusztai, L., Holtrich, U., Iwamoto, T., Shiang, C. Y., Schmidt, M., Müller, V., Solbach, C., Gaetje, R., Hanker, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028403 · Cited by 95 · see citing works
FGF18 as a prognostic and therapeutic biomarker in ovarian cancer
Wei, W., Mok, S. C., Oliva, E., Kim, S., Mohapatra, G., & Birrer, M. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70625 · Cited by 94 · see citing works
Zou, A., Lambert, D. L., Yeh, H., Yasukawa, K., Behbod, F., Fan, F., & Cheng, N. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-781 · Cited by 93 · see citing works
Cytokine properties of prokineticins
Monnier, J., & Samson, M. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06559.x · Cited by 87 · see citing works
Sobolik, T., Su, Y., Wells, S., Ayers, G. D., Cook, R. S., & Richmond, A. J. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-07-0360 · Cited by 85 · see citing works
Sharif, G. M., Schmidt, M. O., Yi, C., Hu, Z., Haddad, B. R., Glasgow, E. F., Riegel, A. T., & Wellstein, A. (2015) · Oncogene · doi:10.1038/onc.2015.44 · Cited by 78 · see citing works
Grépin, R., Guyot, M., Jacquin, M., Durivault, J., Chamorey, E., Sudaka, A., Serdjebi, C., Lacarelle, B., Scoazec, J., Négrier, S., et al. (2011) · Oncogene · doi:10.1038/onc.2011.360 · Cited by 76 · see citing works
Escobar, P., Bouclier, C., Serret, J., Bièche, I., Brigitte, M., Caicedo, A., Sanchez, E., Vacher, S., Vignais, M., Bourin, P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4732 · Cited by 76 · see citing works
Self-citationTong, H., Ke, J., Jiang, F., Wang, X., Wang, F., Li, Y., Lu, W., & Wan, X. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.036 · Cited by 75 · see citing works
Kim, D. S., Lee, M. W., Yoo, K. H., Lee, T.-H., Kim, H. J., Jang, I. K., Chun, Y. H., Kim, H. J., Park, S., Lee, S. H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083363 · Cited by 73 · see citing works
Matsumoto, H., & Kiryu, H. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1109-3 · Cited by 71 · see citing works
Beatson, R., Graham, R. A., Grundland-Freile, F., Cozzetto, D., Kannambath, S., Pfeifer, E., Woodman, N. L., Owen, J., Nuamah, R. A., Mandel, U., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01359-5 · Cited by 71 · see citing works
CXCL3 positively regulates adipogenic differentiation
Kusuyama, J., Komorizono, A., Bandow, K., Ohnishi, T., & Matsuguchi, T. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m067207 · Cited by 70 · see citing works
CXCL2, a new critical factor and therapeutic target for cardiovascular diseases
Guo, L., Yang, F., Peng, L., Li, Y., & Wang, A. (2019) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2019.1693585 · Cited by 69 · see citing works
Vogel, C. F. A., Li, W., Wu, D., Miller, J. K., Sweeney, C. A., Lazennec, G., Fujisawa, Y., & Matsumura, F. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.011 · Cited by 68 · see citing works
Self-citationChemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers
Miyake, M., Lawton, A., Steve Goodison, B., Urquidi, V., Gomes-Giacoia, E., Zhang, G., Ross, S., Kim, J.-S., & Rosser, C. J. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-322 · Cited by 68 · see citing works
Carine Chavey, A., Mühlbauer, M., Bossard, C., Freund, A., Durand, S., Jørgensen, C., Jobin, C., & Lazennec, G. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.047332 · Cited by 65 · see citing works
Self-citationOverexpression of CXCL3 can enhance the oncogenic potential of prostate cancer
Gui, S.-L., Teng, L. L., Wang, S., Liu, S., Lin, Y.-L., Zhao, X., Liu, L., Sui, H., Yang, Y., Liang, L., et al. (2016) · International Urology and Nephrology · doi:10.1007/s11255-016-1222-2 · Cited by 59 · see citing works
Sun, G., Li, Y., Peng, Y., Lu, D., Zhang, F., Cui, X., Zhang, Q., & Zhuang, L. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28163 · Cited by 57 · see citing works
Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis
Verbeke, H., Struyf, S., Berghmans, N., Coillie, E. V., Opdenakker, G., Uyttenhove, C., Snick, J. V., & Damme, J. V. (2011) · Cancer Letters · doi:10.1016/j.canlet.2010.12.013 · Cited by 57 · see citing works
Kowalczuk, O., Burzykowski, T., Niklinska, W. E., Kozłowski, M., Chyczewski, L., & Nikliński, J. (2014) · Tumor Biology · doi:10.1007/s13277-014-1605-x · Cited by 55 · see citing works
Sheldon, R. D., Roseguini, B. T., Thyfault, J. P., Crist, B. D., Laughlin, M. H., & Newcomer, S. C. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00042.2012 · Cited by 54 · see citing works
Zhang, L., Zhang, L., Li, H., Ge, C., Zhao, F., Tian, H., Chen, T., Jiang, G., Xie, H., Cui, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep27426 · Cited by 54 · see citing works
Prognostic significance of CXCL5 expression in cancer patients: a meta-analysis
Hu, B., Fan, H., Lv, X., Chen, S., & Shao, Z. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0562-7 · Cited by 53 · see citing works
Balasubramanian, S., Venugopal, P., SundarRaj, S., Zakaria, Z., Majumdar, A. S., & Ta, M. (2011) · Cytotherapy · doi:10.3109/14653249.2011.605119 · Cited by 52 · see citing works
Identifying and targeting tumor-initiating cells in the treatment of breast cancer
Wei, W., & Lewis, M. T. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0447 · Cited by 51 · see citing works
Sales, K. J., Maldonado‐Pérez, D., Grant, V., Catalano, R. D., Wilson, M., Brown, P., Williams, A. R. W., Anderson, R. A., Thompson, E. A., & Jabbour, H. N. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.018 · Cited by 51 · see citing works
Cancer Stem Cells and Metastasis
Nandy, S., & Lakshmanaswamy, R. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.07.007 · Cited by 50 · see citing works
Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype
Allouch, S., Gupta, I., Malik, S., Farsi, H. F. A., Vranić, S., & Moustafa, A. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.580345 · Cited by 50 · see citing works
Korbecki, J., Bosiacki, M., Barczak, K., Łagocka, R., Brodowska, A., Chlubek, D., & Baranowska‐Bosiacka, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087262 · Cited by 49 · see citing works
Karn, T., Pusztai, L., Ruckhäberle, E., Liedtke, C., Müller, V., Schmidt, M., Metzler, D., Wang, J., Coombes, K. R., Gätje, R., et al. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.06.025 · Cited by 48 · see citing works
Divella, R., Daniele, A., Savino, E., Palma, F., Bellizzi, A., Giotta, F., SIMONE, G. D., Lioce, M., Quaranta, M., Paradiso, A., et al. (2013) · PubMed · Cited by 47 · see citing works
Morandi, F., Scaruffi, P., Gallo, F., Stigliani, S., Moretti, S., Bonassi, S., Gambini, C., Mazzocco, K., Fardin, P., Haupt, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029922 · Cited by 47 · see citing works
Roberti, M. P., Arriaga, J. M., Bianchini, M., Quintá, H. R., Bravo, A., Levy, E. M., Mordoh, J., & Barrio, M. M. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.21187 · Cited by 47 · see citing works
Miyake, M., Furuya, H., Onishi, S., Hokutan, K., Anai, S., Chan, O. T. M., Shi, S., Fujimoto, K., Steve Goodison, B., Cai, W., et al. (2019) · Theranostics · doi:10.7150/thno.29553 · Cited by 47 · see citing works
Tiainen, L., Hämäläinen, M., Luukkaala, T. H., Tanner, M., Lahdenperä, O., Vihinen, P., Jukkola‐Vuorinen, A., Karihtala, P., Moilanen, E., & Kellokumpu‐Lehtinen, P. (2019) · Clinical Breast Cancer · doi:10.1016/j.clbc.2019.03.006 · Cited by 47 · see citing works
Giuliano, S., Dufies, M., Ndiaye, P. D., Viotti, J., Borchiellini, D., Parola, J., Vial, V., Cormerais, Y., Ohanna, M., Imbert, V., et al. (2019) · Theranostics · doi:10.7150/thno.29093 · Cited by 46 · see citing works
Wolff, H. A., Rolke, D., Rave‐Fränk, M., Schirmer, M., Eicheler, W., Doerfler, A., Hille, A., Hess, C. F., Matthias, C., Rödel, R. M. W., et al. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0341-x · Cited by 45 · see citing works
Grand, M. M., Singh, V. K., Ghimenti, C., Scatolini, M., Regolo, L., Grosso, E., Zambelli, A., Prada, G. A. D., Villani, L., Fregoni, V., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0887-y · Cited by 45 · see citing works
Zhang, H., Hou, L., Li, C. M., & Zhang, W. Y. (2013) · Human Reproduction · doi:10.1093/humrep/det258 · Cited by 45 · see citing works
Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes
Zeng, X.-H., Ou, Z.-L., Yu, K., Feng, L.-Y., Yin, W.-J., Li, J., Shen, Z., & Shao, Z. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0875-2 · Cited by 44 · see citing works
Klepacki, H., Kowalczuk, K., Łepkowska, N., & Hermanowicz, J. M. (2025) · Cells · doi:10.3390/cells14130942 · Cited by 44 · see citing works
Namløs, H. M., Kresse, S. H., Müller, C. R., Henriksen, J. M., Holdhus, R., Sæter, G., Bruland, Ø. S., Bjerkehagen, B., Steen, V. M., & Myklebost, O. (2012) · Sarcoma · doi:10.1155/2012/639038 · Cited by 42 · see citing works
Asztalos, S., Pham, T. D., Gann, P. H., Hayes, M. K., Deaton, R. J., Wiley, E. L., Emmadi, R., Kajdacsy‐Balla, A., Banerji, N., McDonald, W., et al. (2015) · SpringerPlus · doi:10.1186/s40064-015-1512-7 · Cited by 43 · see citing works
Yan, R., Shuai, H., Luo, X., Wang, X., & Guan, B. (2017) · Bioscience Reports · doi:10.1042/bsr20171021 · Cited by 41 · see citing works
Functions of the CXC ligand family in the pancreatic tumor microenvironment
Lee, N., Nikfarjam, M., & He, H. Z. (2018) · Pancreatology · doi:10.1016/j.pan.2018.07.011 · Cited by 41 · see citing works
Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer
Timaxian, C., Vogel, C. F. A., Orcel, C., Vetter, D., Durochat, C., Chinal, C., NGuyen, P., Aknin, M.-L. R., Mercier‐Nomé, F., Davy, M., et al. (2021) · Cancers · doi:10.3390/cancers13112584 · Cited by 41 · see citing works
Self-citationSimilar NF-κB Gene Signatures in TNF-α Treated Human Endothelial Cells and Breast Tumor Biopsies
Perrot‐Applanat, M., Vacher, S., Toullec, A., Pelaez-Garavito, I., Velasco, G., Cormier, F., Saad, H. E. S., Lidereau, R., Baud, V., & Bièche, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021589 · Cited by 41 · see citing works
Self-citationTargeting IL-8 signalling to inhibit breast cancer stem cell activity
Singh, J. K., Simões, B. M., Clarke, R. B., & Bundred, N. J. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.835398 · Cited by 41 · see citing works
Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer
Sweeney, C. A., Lazennec, G., & Vogel, C. F. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1095289 · Cited by 39 · see citing works
Self-citationLou, N., Richard, M. L., Yu, J., Kindy, M. S., & Zhang, X. K. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.11.007 · Cited by 39 · see citing works
Yoshida, T., Kobayashi, T., Itoda, M., Muto, T., Miyaguchi, K., Mogushi, K., Shoji, S., Shimokawa, K., Iida, S., Uetake, H., et al. (2010) · Cancer Informatics · doi:10.4137/cin.s3851 · Cited by 38 · see citing works
Wang, Q., Wang, S., Zhang, Y., Yu, Y., Zhao, H., Yang, H., Zheng, L., Yang, M., & Qin, Q. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.08.015 · Cited by 38 · see citing works
Prognostic Value of CXCR2 in Breast Cancer
Boissière‐Michot, F., Jacot, W., Fraisse, J., Gourgou, S., Timaxian, C., & Lazennec, G. (2020) · Cancers · doi:10.3390/cancers12082076 · Cited by 38 · see citing works
Self-citationBoissière‐Michot, F., Jacot, W., Massol, O., Mollévi, C., & Lazennec, G. (2021) · Cancers · doi:10.3390/cancers13102328 · Cited by 38 · see citing works
Self-citationFang, W. B., Jokar, I., Chytil, A. M., Moses, H. L., Abel, T. W., & Cheng, N. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9373-0 · Cited by 37 · see citing works
CXCR2 Mediates Distinct Neutrophil Behavior in Brain Metastatic Breast Tumor
Safarulla, S., Madan, A., Xing, F., & Chandrasekaran, A. (2022) · Cancers · doi:10.3390/cancers14030515 · Cited by 36 · see citing works
Pan, H., Peng, Z., Lin, J., Ren, X., Zhang, G., & Cui, Y. (2018) · Cancer Science · doi:10.1111/cas.13823 · Cited by 37 · see citing works
CXCL3: A key player in tumor microenvironment and inflammatory diseases
Bao, Y., Tong, C., & Xiong, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122691 · Cited by 36 · see citing works
Robin, F., Angenard, G., Cano, L., Courtin-Tanguy, L., Gaignard, E., Khene, Z., Bergeat, D., Clément, B., Boudjéma, K., Coulouarn, C., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0863-1 · Cited by 34 · see citing works
Smadja, D. M., Bièche, I., Susen, S., Mauge, L., Laurendeau, I., d’Audigier, C., Grelac, F., Emmerich, J., Aiach, M., & Gaussem, P. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00429.x · Cited by 34 · see citing works
Toraih, E. A., Fawzy, M. S., El-Falouji, A. I., Hamed, E. O., Nemr, N. A., Hussein, M. H., & El‐Fadeal, N. M. A. (2016) · Molecular Medicine · doi:10.2119/molmed.2016.00096 · Cited by 33 · see citing works
Haim, K., Weitzenfeld, P., Meshel, T., & Ben‐Baruch, A. (2011) · Neoplasia · doi:10.1593/neo.101340 · Cited by 32 · see citing works
Gong, Z., Quan, L., Yao, S., Zirpoli, G., Bandera, E. V., Roberts, M., Coignet, J., Cabasag, C. J., Sucheston, L., Hwang, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072619 · Cited by 32 · see citing works
Interleukin-6 and interleukin-8 serum levels in prognosis of hormone-dependent breast cancer
Milovanović, J., Todorović‐Raković, N., & Radulović, M. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.019 · Cited by 32 · see citing works
Cell Density Regulates Cancer Metastasis Via the Hippo Pathway
Sharif, G. M., & Wellstein, A. (2015) · Future Oncology · doi:10.2217/fon.15.268 · Cited by 31 · see citing works
Han, B., Alonso-Valenteen, F., Wang, Z., Deng, N., Lee, T.-Y., Gao, B., Zhang, Y., Xu, Y., Zhang, X., Billet, S., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.07.003 · Cited by 30 · see citing works
Renoir, J. (2012) · Steroids · doi:10.1016/j.steroids.2012.07.019 · Cited by 31 · see citing works
Regulation of CXCL8/IL-8 Expression by Zonula Occludens-1 in Human Breast Cancer Cells
Brysse, A., Mestdagt, M., Polette, M., Luczka, E., Hunziker, W., Noël, A., Birembaut, P. L., Foidart, J., & Gilles, C. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0180 · Cited by 30 · see citing works
CXCR2 intrinsically drives the maturation and function of neutrophils in mice
Delobel, P., Ginter, B., Rubio, E., Balabanian, K., & Lazennec, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1005551 · Cited by 29 · see citing works
Self-citationToomajian, V., Tundo, A., Ural, E. E., Greeson, E. M., Contag, C. H., & Makela, A. V. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04920 · Cited by 29 · see citing works
Milovanović, J., Todorović‐Raković, N., & Rabi, Z. A. (2013) · PubMed · Cited by 29 · see citing works
CXCL3 Signaling in the Tumor Microenvironment
Reyes, N., Figueroa, S., Tiwari, R. K., & Geliebter, J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62658-7_2 · Cited by 28 · see citing works
CXCL13 Signaling in the Tumor Microenvironment.
Hussain, M., Liu, J.-S., Wang, G.-Z., & Zhou, G.-B. (2021) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-62658-7_6 · Cited by 24 · see citing works
Molecular cloning and biophysical characterization of CXCL3 chemokine
Gulati, K., Gangele, K., Agarwal, N., Jamsandekar, M., Kumar, D., & Poluri, K. M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.09.032 · Cited by 26 · see citing works
- Authors
- Bieche, I., Chavey, C., Andrieu, C., Busson, M., Vacher, S., Le Corre, L., Guinebretiere, J.-M., Burlinchon, S., Lidereau, R., & Lazennec, G.
- Affiliations
- Inserm (FR)
- Venue
- Endocrine Related Cancer
- Publisher
- Bioscientifica
- Published
- 2007-12-01
- Volume
- 14
- Issue
- 4
- Pages
- 1039-1052
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2163873875
- Cited by
- 183
- References
- 49
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 19 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 7 · 2013: 13 · 2012: 14
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Related Cancer (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Ligue Contre le Cancer
- Association pour la Recherche sur les Tumeurs de la Prostate
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- CXC chemokines, breast cancer, chromosome 4q21, interleukin-8, estrogen receptor alpha, metastasis, AP-1 pathway, NF-κB signaling, gene transcription, tamoxifen, relapse-free survival, tumor aggressiveness
- MeSH terms
- Aged, Breast Neoplasms, Cells, Cultured, Chromosome Mapping, Chromosomes, Human, Pair 4, Endothelium, Vascular, Female, Humans, Lymphatic Metastasis, Middle Aged, Umbilical Veins, Up-Regulation, Gene Expression Regulation, Neoplastic, Disease-Free Survival, Chemokines, CXC, Reverse Transcriptase Polymerase Chain Reaction
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