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17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
Open accessAbstract
A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of novel 17HSD/KSR enzymes are presented.
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“There are at least 14 human 17HSD isoforms; these isoforms vary widely in size, structure, substrate specificity, cofactor utilization, and physiological functions (502).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [502]
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“The widespread tissue distribution and broad substrate specificity of 17HSD2 suggests that its role in human physiology is to protect tissues from excessive exposure to active steroid hormones by oxidation to inactive 17-ketosteroids (502).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [502]
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“Estrone undergoes 16α-hydroxylation and HSD17B1 catalyzed reduction, while 17β-estradiol only requires 16α-hydroxylation [[311], [312], [313], [314]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [311]
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Metadata
- Authors
- Peltoketo, H., Luu-The, V, Simard, J., & Adamski, J.
- Affiliations
- University of Oulu (FI)
- Centre hospitalier de l'Université Laval (CA)
- Helmholtz Munich (DE)
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 1999-08-01
- Volume
- 23
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2116838171
- Semantic Scholar
- 09af775fcb4aa1e427eb5e859c6ee8074a5ccf34
- Cited by
- 302
- References
- 101
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Deutsche Forschungsgemeinschaft
- Medical Research Council Canada
- Medical Research Council
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- 17β-hydroxysteroid dehydrogenase, enzyme nomenclature, enzyme classification, steroid metabolism
- MeSH terms
- Animals, Humans, Terminology as Topic, 17-Hydroxysteroid Dehydrogenases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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