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17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
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A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of novel 17HSD/KSR enzymes are presented.
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“There are at least 14 human 17HSD isoforms; these isoforms vary widely in size, structure, substrate specificity, cofactor utilization, and physiological functions (502).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [502]
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“The widespread tissue distribution and broad substrate specificity of 17HSD2 suggests that its role in human physiology is to protect tissues from excessive exposure to active steroid hormones by oxidation to inactive 17-ketosteroids (502).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [502]
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“Estrone undergoes 16α-hydroxylation and HSD17B1 catalyzed reduction, while 17β-estradiol only requires 16α-hydroxylation [[311], [312], [313], [314]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [311]
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Metadata
- Authors
- Peltoketo, H., Luu-The, V, Simard, J., & Adamski, J.
- Affiliations
- University of Oulu (FI)
- Centre hospitalier de l'Université Laval (CA)
- Helmholtz Munich (DE)
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 1999-08-01
- Volume
- 23
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2116838171
- Semantic Scholar
- 09af775fcb4aa1e427eb5e859c6ee8074a5ccf34
- Cited by
- 302
- References
- 101
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Deutsche Forschungsgemeinschaft
- Medical Research Council Canada
- Medical Research Council
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- 17β-hydroxysteroid dehydrogenase, enzyme nomenclature, enzyme classification, steroid metabolism
- MeSH terms
- Animals, Humans, Terminology as Topic, 17-Hydroxysteroid Dehydrogenases
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