The DOI matches its Crossref record; 108 of the 109 references it cites were found in a registry or an index.
Circadian clocks: regulators of endocrine and metabolic rhythms
Abstract
Daily and seasonal rhythms in the endocrine system are co-ordinated by a hypothalamic pacemaker, the suprachiasmatic nuclei (SCN) that is synchronised to solar time by direct retinal afferents. Individual SCN neurons are circadian clocks, their intrinsic oscillator consisting of a series of interlinked autoregulatory transcriptional/post-translational feedback loops incorporating Period ( Per ) and Cryptochrome ( Cry ) genes. Mutations that alter the rate of transcription of Per and Cry genes or the stability of Per and Cry proteins affect clock speed. Molecular timekeeping in SCN neurons is synchronised and sustained by interneuronal neuropeptidergic signals. A molecular clock mechanism comparable to that of the SCN is present in most major organ systems. These tissue clocks are synchronised by endocrine, autonomic and behavioural cues that are dependent on the SCN, and in turn they drive the circadian expression of local transcriptomes, thereby co-ordinating circadian metabolism and physiology. Rhythmic glucocorticoid signalling is a prominent mediator of SCN output and internal synchroniser. The role of local SCN-synchronised clocks in controlling vital processes, including xenobiotic detoxification, cell division and nutrient metabolism, is essential to health, and disturbances to circadian timing arising from modern working schedules are becoming recognised as an increasingly relevant factor in major systemic illness. Moreover, the newly identified molecular components of circadian control systems provide novel avenues for therapeutic intervention.
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In the citing paper
“The normal function of the circadian system is based on a hierarchical network of central and peripheral clocks [224].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [224]
In the citing paper
“This complex interconnected regulatory framework, ensures that the same molecules that regulate metabolism and reproduction, also contribute to a bidirectional feedback system with the autonomous circadian circuits [224,231]. This results in synchronicity of internal physiology with environmental cues, to optimize both individual and species survival.”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [224]
In the citing paper
“The central clock can then convey rhythmic information to peripheral clocks in other tissues and organs throughout the body [224].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [224]
In the citing paper
“Circadian rhythms are generated by the endogenous master pacemaker located in the paired suprachiasmatic nucleus (SCN) of the hypothalamus and are kept entrained to the local conditions by environmental timing cues; the most important of these cues is light, that signaled to the SCN by direct input from the retina via the retinohypothalamic tract [1].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [1]
Citations
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1 of the 109 references couldn’t be matched to a known paper.
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Items 401–425 of 425
Joshi, K., Das, M., Sarma, A., Arora, M. K., Singhal, M., & Kumar, B. (2023) · Current Hypertension Reviews · doi:10.2174/1573402119666230109142156
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Diurnal variation of peak expiratory flow rate in adolescents
Charles, S., Archana, A., Padmavathy, Priscilla, & Subhashini (2023) · Annals of Geriatric Education and Medical Sciences · doi:10.18231/j.agems.2022.017
Melatonin ve Çinkonun Egzersize Katkıları
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Clock Gene Expression in Eel Retina and Hypothalamus: Response to Photoperiod and Moonlight
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Circadian Rhythm Estimation Based on Knowledge Distillation Without Daytime Heartrate Data
Man, S., & Takadama, K. (2025) · Lecture notes in computer science · doi:10.1007/978-3-031-93822-1_5
The Effects of Time of Day on the Purchase of New Commodity Food Products
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Philippe, M. (2023) · theses.fr (ABES) · doi:10.70675/0649c89czc015z4d7fz8832z596152e96dc1
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Ahmed, S. S., Mehmood, N., Zubair, S., Raza, A. A., & Samadi, A. (2026) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000005066
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Intrauterines Leben und extrem kleine Frühgeborene auf der Neo-Intensivstation
Zeitzschel, U. (2026) · Jahrbuch der Psychoanalyse · doi:10.30820/0075-2363-2026-2-89
Metadata
- Authors
- Hastings, M., O’Neill, J. S., & Maywood, E. S.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2007-11
- Volume
- 195
- Issue
- 2
- Pages
- 187-198
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2149487034
- Cited by
- 426
- References
- 109
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 19 · 2022: 19 · 2021: 30 · 2020: 22 · 2019: 11 · 2018: 29 · 2017: 27 · 2016: 24 · 2015: 26 · 2014: 23 · 2013: 22 · 2012: 23
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- circadian clock, suprachiasmatic nucleus, endocrine rhythms, metabolic rhythms, period gene, transcriptional feedback loop, glucocorticoid signaling, circadian metabolism, circadian rhythm disruption, shift work, xenobiotic detoxification, cell division, nutrient metabolism
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Computer Systems, Endocrine Glands, Fluorescent Dyes, Health, Humans, Light, Neural Pathways, Periodicity, Suprachiasmatic Nucleus, Signal Transduction
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