Cited by 305Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

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Leptin and hyperleptinemia - from friend to foe for cardiovascular function

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Ren, J·2004·Journal of Endocrinology

DOI 10.1677/joe.0.1810001

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Abstract

The obese gene product, leptin, plays a central role in food intake and energy metabolism. The physiological roles of leptin in human bodily function have been broadened over the past decade since leptin was first discovered in 1994. Evidence has suggested that leptin plays a specific role in the intricate cascade of cardiovascular events, in addition to its well-established metabolic effects. Leptin, a hormone linking adiposity and central nervous circuits to reduce appetite and enhance energy expenditure, has been shown to increase overall sympathetic nerve activity, facilitate glucose utilization and improve insulin sensitivity. In addition, leptin is capable of regulating cardiac and vascular contractility through a local nitric oxide-dependent mechanism. However, elevated plasma leptin levels or hyperleptinemia, have been demonstrated to correlate with hyperphagia, insulin resistance and other markers of the metabolic syndrome including obesity, hyperlipidemia and hypertension, independent of total adiposity. Elevated plasma leptin levels may be an independent risk factor for the development of cardiovascular disease. Although mechanisms leading to hyperleptinemia have not been well described, factors such as increased food intake and insulin resistance have been shown to rapidly enhance plasma leptin levels and subsequently tissue leptin resistance. These findings have prompted the speculation that leptin in the physiological range may serve as a physiological regulator of cardiovascular function whereas elevated plasma leptin levels may act as a pathophysiological trigger and/or marker for cardiovascular diseases due to tissue leptin resistance.

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Biochemical and Biophysical Research Communications
Rc, A. N., On Filamentous Bacteriophage, M., Hoffmann, S., & Willbold, D. (1960) · Nature · doi:10.1038/186124d0 · Cited by 6,690
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“…activation of the sympathetic autonomic nervous system and impairment of endothelial function are the two pivotal phenotypical traits in obesity (Steinberg et al. 1996, Julius et al. 2000, Kuo et al. 2003), the cellular mechanisms responsible for sympathetic hyperactivity and endothelial…”
Background
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660

Show all 97 references

Research works printed but not linked: 1

Ahima RS & Flier JS 2000 Leptin. Annual Review of Physiology 62 413-437.

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Sharma, V. K., Mustafa, S., Patel, N., Wambolt, R. B., Allard, M. F., & McNeill, J. H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.037 · Cited by 38
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Na, T., Dai, D. Z., Tang, X. Y., & Dai, Y. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0134-1 · Cited by 37
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Chen, J., Mo, H., Guo, R., You, Q., Huang, R., & Wu, K. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1614 · Cited by 37
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Self-citation
Retracted
Adipokines and coronary vasomotor dysfunction.
Knudson, J. D., Dick, G. M., & Tune, J. D. (2007) · PubMed · Cited by 37
20years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology
Feijóo‐Bandín, S., Portolés, M., Roselló‐Lletí, E., Rivera, M., González‐Juanatey, J. R., & Lago, F. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.02.016 · Cited by 39
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Salman, M. A., El‐ghobary, M., Soliman, A. M., Sherbiny, M. E., Abouelregal, T. E., Albitar, A. R., Abdallah, A., Mikhail, H. M. S., Nafea, M. A., Sultan, A. A. E. A., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04254-z · Cited by 37
Effects of intensity of aerobics on body composition and blood lipid profile in obese/overweight females.
Marandi, S. M., Ghadiri, N., Esfarjani, F., Mojtahedi, H., & Ghasemi, G. (2013) · Europe PMC (PubMed Central) · Cited by 36
Oxidative damage in cerebral vessels of diabetic db/db mice
Liao, Y., Ueno, M., Nakagawa, T., Huang, C., Kanenishi, K., Onodera, M., & Sakamoto, H. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.579 · Cited by 35
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Högberg, H. T., Engblom, L. O. M., Ekdahl, Å., Lidell, V., Walum, E., & Alberts, P. (2006) · Obesity · doi:10.1038/oby.2006.76 · Cited by 34
Untitled work
(2009) · PubMed · Cited by 33
Sympathetic overactivity and plasma leptin levels in Rett syndrome
Acampa, M., Guideri, F., Hayek, J., Blardi, P., De Lalla, A., Zappella, M., & Auteri, A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.030 · Cited by 33
Blood Pressure and Vascular Effects of Leptin in Humans
Brook, R. D., Bard, R. L., Bodary, P. F., Eitzman, D. T., Rajagopalan, S., Sun, Y., & Depaoli, A. M. (2007) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2006.0023 · Cited by 31
Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: a new attractor for peripheral vascular disease?
Butcher, J. T., Goodwill, A. G., Stanley, S., & Frisbee, J. C. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00805.2012 · Cited by 31
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MacLaren, R., Kalant, D., & Cianflone, K. (2007) · Biochemistry and Cell Biology · doi:10.1139/o06-207 · Cited by 30
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Lee, A. M., Charlton, J. R., Carmody, J. B., Gurka, M. J., & DeBoer, M. D. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw231 · Cited by 31
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Dual vascular effects of leptin via endothelium: hypothesis and perspective.
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Baskaran, P., Markert, L., Bennis, J., Zimmerman, L., Fox, J. H., & Thyagarajan, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-45050-0 · Cited by 26
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Dong, F., & Ren, J. T. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e32828626d1 · Cited by 26
Self-citation
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Montagnana, M., Fava, C., Targher, G., Franchini, M., Danese, E., Bonafini, S., Cata, A. D., Salvagno, G. L., Ruzzenente, O., Guidi, G. C., et al. (2016) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22031 · Cited by 24
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Kiviniemi, T., Snapir, A., Saraste, M., Toikka, J., Raitakari, O. T., Ahotupa, M. O., Hartiala, J., Scheinin, M., & Koskenvuo, J. W. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00915.2005 · Cited by 24
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Brock, C. M., King, D. S., Wofford, M. R., & Harrell, T. K. (2005) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2005.3.60 · Cited by 24
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Wójcicka, G., Jamróz-Wiśniewska, A., Widomska, S., Książek, M., & Bełtowski, J. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.11.029 · Cited by 22
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Zhang, Y., Li, F., Jiang, X., Jiang, X., Wang, Y., Zhang, H., Zhang, L. R., Fan, S., Xin, L., Yang, B., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6747 · Cited by 21
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Charles, L. E., Burchfiel, C. M., Sarkisian, K., Li, S., Miller, D. B., Gu, J. K., Fekedulegn, D. B., Violanti, J. M., & Andrew, M. E. (2014) · American Journal of Human Biology · doi:10.1002/ajhb.22636 · Cited by 20
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Mertens, I. L., Considine, R. V., van der Planken, M., & Gaal, L. F. V. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02239 · Cited by 21
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Kyrou, I., Mattu, H. S., Chatha, K. K., & Randeva, H. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803111-7.00007-5 · Cited by 21
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Pereira, R. O., Moreira, A. S. B., de Carvalho, L., & Moura, A. S. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.05.002 · Cited by 21
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Impaired cardiac function in leptin-deficient mice
Ren, J. T., & Ma, H. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0084-0 · Cited by 20
Self-citation
Vitamin D & endothelial function.
Alyami, A., Soares, M. J., Sherriff, J. L., & Mamo, J. C. L. (2014) · PubMed Central · Cited by 19
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Sweatman, C. Z. W. H. (2019) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.110037 · Cited by 19
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Xia, Q.-G., Na, T., Guo, Y., Bi, Y.-T., Zhang, H., & Dai, D. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00503.x · Cited by 19
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Luo, C., Xiao, K., Xiong, S., Sun, Y., Xu, Q., Zhang, W., Lei, Y., Ding, Y., Zhen, Y., Feng, J., et al. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.84854 · Cited by 18
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The Relationship between Obesity and the High Probability of Dementia Based on the Body Mass Index and Waist Circumference
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Simvastatin inhibits leptin-induced hypertrophy in cultured neonatal rat cardiomyocytes1
Tai-ping, H. U., Xu, F., Li, Y., & Luo, J. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00300.x · Cited by 18
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Li, L., Hua, Y., Dong, M., Li, Q., Smith, D. T., Yuan, M., Jones, K. R., & Ren, J. T. (2012) · Obesity · doi:10.1038/oby.2012.106 · Cited by 18
Self-citation
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Toit, E. F. D., & Donner, D. G. (2012) · InTech eBooks · doi:10.5772/50619 · Cited by 18
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Jois, A., Navarro, P., Ortega, H., Gavela‐Pérez, T., Soriano‐Guillén, L., & Garcés, C. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.09.005 · Cited by 17
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Self-citation
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Horoz, M., Aslan, M., Köylü, A. Ö., Bölükbaş, C., Bölükbaş, F. F., Selek, Ş., & Erel, Ö. (2009) · Artificial Organs · doi:10.1111/j.1525-1594.2008.00678.x · Cited by 14
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Microcirculation in obesity: an unexplored domain.
Wiernsperger, N., Nivoit, P., & Bouskela, E. (2007) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652007000400005 · Cited by 10
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Authors: Ren, J.
Affiliations: University of Wyoming (US)
Corresponding author: Ren, J
ORCID: Ren, J
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 2004-04-01
Volume: 181
Issue: 1
Pages: 1-10
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1677/joe.0.1810001
OpenAlex: W2097827059
Cited by: 305
References: 97
Citations by year: 2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 12 · 2021: 12 · 2020: 6 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 14 · 2014: 16 · 2013: 18 · 2012: 19
FWCI: 2.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
American Heart Association
National Institutes of Health
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: leptin, hyperleptinemia, cardiovascular disease, leptin resistance, insulin resistance, metabolic syndrome, obesity, hypertension, hyperlipidemia, sympathetic activity, insulin sensitivity, nitric oxide, cardiac contractility, vascular contractility, cardiovascular risk factors
MeSH terms: Appetite Regulation, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Energy Metabolism, Heart Rate, Humans, Insulin, Obesity, Receptors, Cell Surface, Sympathetic Nervous System, Signal Transduction, Leptin, Receptors, Leptin

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Leptin and hyperleptinemia - from friend to foe for cardiovascular function

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