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Leptin and hyperleptinemia - from friend to foe for cardiovascular function
Open accessAbstract
The obese gene product, leptin, plays a central role in food intake and energy metabolism. The physiological roles of leptin in human bodily function have been broadened over the past decade since leptin was first discovered in 1994. Evidence has suggested that leptin plays a specific role in the intricate cascade of cardiovascular events, in addition to its well-established metabolic effects. Leptin, a hormone linking adiposity and central nervous circuits to reduce appetite and enhance energy expenditure, has been shown to increase overall sympathetic nerve activity, facilitate glucose utilization and improve insulin sensitivity. In addition, leptin is capable of regulating cardiac and vascular contractility through a local nitric oxide-dependent mechanism. However, elevated plasma leptin levels or hyperleptinemia, have been demonstrated to correlate with hyperphagia, insulin resistance and other markers of the metabolic syndrome including obesity, hyperlipidemia and hypertension, independent of total adiposity. Elevated plasma leptin levels may be an independent risk factor for the development of cardiovascular disease. Although mechanisms leading to hyperleptinemia have not been well described, factors such as increased food intake and insulin resistance have been shown to rapidly enhance plasma leptin levels and subsequently tissue leptin resistance. These findings have prompted the speculation that leptin in the physiological range may serve as a physiological regulator of cardiovascular function whereas elevated plasma leptin levels may act as a pathophysiological trigger and/or marker for cardiovascular diseases due to tissue leptin resistance.
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“In general, the ob/ob mouse model is rather unique (plasma leptin levels are increased in almost all other obese rodent models and in humans, Ref. 297) and may not precisely reflect the alterations observed in human obesity.”
From Cardiac remodeling in obesity (2008) · cites this paper as [297]
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Biochemical and Biophysical Research Communications
Rc, A. N., On Filamentous Bacteriophage, M., Hoffmann, S., & Willbold, D. (1960) · Nature · doi:10.1038/186124d0 · Cited by 6,690
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“…activation of the sympathetic autonomic nervous system and impairment of endothelial function are the two pivotal phenotypical traits in obesity (Steinberg et al. 1996, Julius et al. 2000, Kuo et al. 2003), the cellular mechanisms responsible for sympathetic hyperactivity and endothelial…”
BackgroundFrederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
Research works printed but not linked: 1
- Ahima RS & Flier JS 2000 Leptin. Annual Review of Physiology 62 413-437.
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Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 693
Baker, A. R., da Silva, N. F., Quinn, D. W., Harte, A. L., Pagano, D., Bonser, R. S., Kumar, S., & McTernan, P. G. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-1 · Cited by 646
Bełtowski, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.003 · Cited by 484
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Zhao, S., Kusminski, C. M., & Scherer, P. E. (2021) · Circulation Research · doi:10.1161/circresaha.120.314458 · Cited by 415
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Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 388
Self-citationBaskaran, P., Krishnan, V., Ren, J. T., & Thyagarajan, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13514 · Cited by 325
Self-citationShimizu, H., Oh-I, S., Hashimoto, K., Nakata, M., Yamamoto, S., Yoshida, N., Eguchi, H., Kato, I., Inoue, K., Satoh, T., et al. (2009) · Endocrinology · doi:10.1210/en.2008-0598 · Cited by 323
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Mattu, H. S., & Randeva, H. S. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0232 · Cited by 298
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Spanova, M., & Daum, G. (2011) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201100203 · Cited by 268
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Bełtowski, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000222743.06584.66 · Cited by 220
Interactive relations of central versus total obesity and blood pressure to cognitive function
Waldstein, S. R., & Katzel, L. I. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803114 · Cited by 200
Knudson, J. D., Dinçer, Ü. D., Zhang, C., Swafford, A. N., Koshida, R., Picchi, A., Focardi, M., Dick, G. M., & Tune, J. D. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01159.2004 · Cited by 196
Li, S.-Y., Yang, X., Ceylan-Isik, A. F., Du, M., Sreejayan, N., & Ren, J. (2006) · Diabetologia · doi:10.1007/s00125-006-0229-0 · Cited by 187
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Sattar, N. A., Wannamethee, S. G., Sarwar, N., Tchernova, J., Lawlor, D. A., Kelly, A., Wallace, A. M., Danesh, J., & Whincup, P. H. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.035 · Cited by 172
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Vilariño‐García, T., Polonio-González, M., Pérez‐Pérez, A., Ribalta, J., Arrieta, F., Aguilar‐Diosdado, M., Obaya, J. C., Gimeno-Orna, J. A., Iglesias, P., Navarro, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042338 · Cited by 201
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Price, T. O., Samson, W. K., Niehoff, M. L., & Banks, W. A. (2007) · Peptides · doi:10.1016/j.peptides.2007.10.008 · Cited by 163
Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice
Dong, F., Zhang, X., Yang, X., Esberg, L. B., Yang, H., Zhang, Z., Culver, B., & Ren, J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06241 · Cited by 155
Self-citationJaganathan, R., Ravindran, R., & Dhanasekaran, S. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.040 · Cited by 154
Leptin, the obesity‐associated hormone, exhibits direct cardioprotective effects
Smith, C. C. T., Mocanu, M. M., Davidson, S. M., Wynne, A. M., Simpkin, J. C., & Yellon, D. M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706834 · Cited by 153
Wennersberg, M. H., Smedman, A., Turpeinen, A. M., Retterstøl, K., Tengblad, S., Lipre, E., Aro, A., Mutanen, P., Seljeflot, I., Basu, S., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27664 · Cited by 160
Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies
Hamerman, D. (2005) · QJM · doi:10.1093/qjmed/hci077 · Cited by 146
Baker, A. R., Harte, A. L., Howell, N., Pritlove, D. C., Ranasinghe, A. M., da Silva, N. F., Youssef, E. M., Khunti, K., Davies, M. J., Bonser, R. S., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2579 · Cited by 131
Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis
Adya, R., Tan, B. K., & Randeva, H. S. (2015) · Journal of Diabetes Research · doi:10.1155/2015/648239 · Cited by 130
Dong, F., Zhang, X., & Ren, J. T. (2005) · Hypertension · doi:10.1161/01.hyp.0000198555.51645.f1 · Cited by 123
Self-citationHuman obesity and endothelium‐dependent responsiveness
Campia, U., Tesauro, M., & Cardillo, C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01661.x · Cited by 124
Maya‐Monteiro, C. M., de Almeida, P. E., D’Ávila, H., Martins, A. S., Rezende, A. P., Castro-Faria-Neto, H. C., & Bozza, P. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706706200 · Cited by 121
Gray, B. R., Steyn, F. J., Davies, P. S. W., & Vitetta, L. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.197 · Cited by 118
The effect of PPARγ ligands on the adipose tissue in insulin resistance
Hammarstedt, A., Andersson, C. X., Sopasakis, V. R., & Smith, U. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.008 · Cited by 119
Endothelial dysfunction: role in obesity-related disorders and the early origins of CVD
Singhal, A. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004404 · Cited by 115
Baskaran, P., Krishnan, V., Fettel, K. D., Gao, P., Zhu, Z., Ren, J. T., & Thyagarajan, B. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.16 · Cited by 119
Self-citationAdipokines and Inflammation: Focus on Cardiovascular Diseases
Feijóo‐Bandín, S., Aragón‐Herrera, A., Moraña‐Fernández, S., Anido‐Varela, L., Tarazón, E., Roselló‐Lletí, E., Portolés, M., Moscoso, I., Gualillo, O., González‐Juanatey, J. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207711 · Cited by 127
Cardiac Health in Women With Metabolic Syndrome: Clinical Aspects and Pathophysiology
Ren, J. T., & Kelley, R. O. (2009) · Obesity · doi:10.1038/oby.2009.8 · Cited by 110
Self-citationAdipose tissue, inflammation and cardiovascular disease
Ikeoka, D., Mader, J. K., & Pieber, T. R. (2010) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302010000100026 · Cited by 110
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do Nascimento, A. F., Sugizaki, M. M., Leopoldo, A. S., Lima‐Leopoldo, A. P., Luvizotto, R. D. A. M., Nogueira, C. R., & Cicogna, A. C. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000600007 · Cited by 110
Aghamohammadzadeh, R., Withers, S., Lynch, F. M., Greenstein, A. S., Malik, R. A., & Heagerty, A. M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01479.x · Cited by 107
Ulrich‐Lai, Y. M., & Ryan, K. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.020 · Cited by 113
Christopoulou, F., & Kiortsis, D. N. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2010.01164.x · Cited by 99
Kelley, E. E., Baust, J., Bonacci, G., Golin-Bisello, F., Devlin, J. E., St. Croix, C. M., Watkins, S. C., Gor, S., Cantu-Medellin, N., Weidert, E. R., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvt341 · Cited by 95
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Ren, J. T., & Ceylan‐Isik, A. F. (2004) · Endocrine · doi:10.1385/endo:25:2:073 · Cited by 88
Self-citationMacías-Cervantes, M. H., Rodríguez-Soto, J. M. D., Uribarri, J., Díaz-Cisneros, F. J., Cai, W., & Garay‐Sevilla, M. E. (2014) · Nutrition · doi:10.1016/j.nut.2014.10.004 · Cited by 89
Shimizu, H., Inoue, K., & Mori, M. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0144 · Cited by 88
Bougoulia, M., Triantos, A., & Koliakos, G. (2006) · HORMONES · doi:10.14310/horm.2002.11190 · Cited by 85
Sloan, C., Tuinei, J., Nemetz, K., Frandsen, J. E., Soto, J. E., Wride, N., Sempokuya, T., Alegria, L., Bugger, H., & Abel, E. D. (2011) · Diabetes · doi:10.2337/db10-1106 · Cited by 86
Felipe, F., Mercader, J., Ribot, J., Palou, A., & Bonet, M. L. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.014 · Cited by 80
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Zhang, Y., Yu, L., Cai, W., Fan, S., Li, F., Ji, G., & Huang, C. (2014) · Scientific Reports · doi:10.1038/srep07375 · Cited by 74
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Yan Fang, G. O. N. G., Li, G., Tao, J., Wu, N. N., Kandadi, M. R., Bi, Y., Wang, S., Pei, Z., & Ren, J. T. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165855 · Cited by 66
Self-citationShin, H.-J., Oh, J., Kang, S., Lee, J. H., Shin, M., Hwang, K.-C., Jang, Y., & Chung, J. H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.195 · Cited by 70
Hirasaka, K., Kohno, S., Goto, J., Furochi, H., Mawatari, K., Harada, N., Hosaka, T., Nakaya, Y., Ishidoh, K., Obata, T., et al. (2007) · Diabetes · doi:10.2337/db06-1768 · Cited by 69
Mitsis, A., Kadoglou, N. P. E., Lambadiari, V., Alexiou, S., Theodoropoulos, K. C., Avraamides, P., & Kassimis, G. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155848 · Cited by 73
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Hill, M. J., Metcalfe, D., & McTernan, P. G. (2008) · Clinical Science · doi:10.1042/cs20080050 · Cited by 69
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Noh, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.010 · Cited by 68
Eckel, R. H. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005320 · Cited by 69
Induced pluripotent stem cells as a model for diabetes investigation
Stępniewski, J., Kachamakova‐Trojanowska, N., Ogrocki, D., Szopa, M., Matłok, M., Beilharz, M., Dyduch, G., Malecki, M. T., Józkowicz, A., & Dulak, J. (2015) · Scientific Reports · doi:10.1038/srep08597 · Cited by 67
The impairment of preconditioning-mediated cardioprotection in pathological conditions
Balakumar, P., Singh, H. S., Singh, M., & Anand‐Srivastava, M. B. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.002 · Cited by 67
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Eguchi, M., Liu, Y.-T., Shin, E., & Sweeney, G. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06465.x · Cited by 67
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Park, Y., Booth, F. W., Lee, S., Laye, M. J., & Zhang, C. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.234856 · Cited by 66
Nemes, A., Homoki, J. R., Kiss, R., Hegedűs, C., Kovács, D. K., Peitl, B., Gal, F., Stündl, L., Szilvássy, Z., & Remenyik, J. (2019) · Nutrients · doi:10.3390/nu11091966 · Cited by 72
Adiposity, leptin and stress reactivity in humans
Brydon, L. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.02.010 · Cited by 64
Corticotropin releasing hormone and the immune/inflammatory response
Mastorakos, G. P., Karoutsou, E., & Mizamtsidi, M. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02243 · Cited by 64
New drug targets for hypertension: A literature review
Gao, Q., Xu, L., & Cai, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166037 · Cited by 68
Perceived Psychological Stress and Serum Leptin Concentrations in Japanese Men
Otsuka, R., Yatsuya, H., Tamakoshi, K., Matsushita, K., Wada, K., & Toyoshima, H. (2006) · Obesity · doi:10.1038/oby.2006.211 · Cited by 61
Knudson, J. D., Dinçer, Ü. D., Dick, G. M., Shibata, H., Akahane, R., Saito, M., & Tune, J. D. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00244.2005 · Cited by 60
Chen, V. C., Chen, C.-H., Chiu, Y.-H., Lin, T., Li, F.-C., & Lu, M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.021 · Cited by 60
Minhas, K. M., Khan, S. A., Raju, S. V. Y., Phan, A. C., Gonzalez, D. R., Skaf, M. W., Lee, K., Tejani, A. D., Saliaris, A. P., Barouch, L. A., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.084566 · Cited by 59
Chess, D. J., Khairallah, R. J., O’Shea, K. M., Xu, W., & Stanley, W. C. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00599.2009 · Cited by 58
Rescue of cardiac leptin receptors indb/dbmice prevents myocardial triglyceride accumulation
Hall, M. E., Maready, M. W., Hall, J. E., & Stec, D. E. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00005.2014 · Cited by 55
Increased cardiovascular risk markers in obesity are associated with body adiposity: Role of leptin
Gómez‐Ambrosi, J., Salvador, J., Silva, C., Pastor, C., Rotellar, F., Gil, M., Cienfuegos, J. A., & Frühbeck, G. (2006) · Thrombosis and Haemostasis · doi:10.1160/th06-02-0079 · Cited by 55
Paulino, E. C., Ferreira, J. C. B., Bechara, L. R. G., Tsutsui, J. M., Mathias, W., Lima, F. B., Casarini, D. E., Cicogna, A. C., Brum, P. C., & Negrão, C. E. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.156141 · Cited by 56
Leptin in pediatrics: A hormone from adipocyte that wheels several functions in children
Soliman, A. T., Yasin, M., & Kassem, A. S. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105575 · Cited by 53
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Wang, T., Zhai, M., Xu, S., Ponnusamy, M., Huang, Y. H., Liu, C.-Y., Wang, M., Shan, C., Shan, P., Gao, X., et al. (2019) · Theranostics · doi:10.7150/thno.37181 · Cited by 53
St-Pierre, D., Faraj, M., Karelis, A. D., Conus, F., Henry, J., St-Onge, M., Tremblay-Lebeau, A., Cianflone, K., & RABASA-LHORET, R. P. R. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70259-8 · Cited by 52
Schram, K., Wong, M. M. K., Palanivel, R., No, E. K., Dixon, I., & Sweeney, G. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.005 · Cited by 49
Treatment of prehypertension: lifestyle and/or medication
Collier, S. R., & Landram, M. J. (2012) · Vascular Health and Risk Management · doi:10.2147/vhrm.s29138 · Cited by 54
Coudriet, G. M., Delmastro-Greenwood, M. M., Previte, D. M., Marré, M. L., O’Connor, E., Novak, E. M., Vincent, G., Mollen, K. P., Lee, S., Dong, H. H., et al. (2017) · Antioxidants · doi:10.3390/antiox6040085 · Cited by 50
The association of short-chain fatty acids and leptin metabolism: a systematic review
Gabriel, F. C., & Fantuzzi, G. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.08.006 · Cited by 57
Circulating Leptin and Stress‐induced Cardiovascular Activity in Humans
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Self-citationSutton, E. F., Lob, H. E., Song, J., Xia, Y., Butler, S. D., Liu, C., Redman, L. M., & Sones, J. L. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00512.2016 · Cited by 42
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Ekmen, N., Helvacı, A., Günaldı, M., Sasanı, H., & Yıldırmak, S. (2016) · Indian Heart Journal · doi:10.1016/j.ihj.2015.07.032 · Cited by 40
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Metadata
- Authors
- Ren, J.
- Affiliations
- University of Wyoming (US)
- Corresponding author
- Ren, J
- ORCID
- Ren, J
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2004-04-01
- Volume
- 181
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2097827059
- Cited by
- 305
- References
- 97
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 12 · 2021: 12 · 2020: 6 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 14 · 2014: 16 · 2013: 18 · 2012: 19
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- American Heart Association
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- leptin, hyperleptinemia, cardiovascular disease, leptin resistance, insulin resistance, metabolic syndrome, obesity, hypertension, hyperlipidemia, sympathetic activity, insulin sensitivity, nitric oxide, cardiac contractility, vascular contractility, cardiovascular risk factors
- MeSH terms
- Appetite Regulation, Blood Glucose, Blood Pressure, Cardiovascular Diseases, Energy Metabolism, Heart Rate, Humans, Insulin, Obesity, Receptors, Cell Surface, Sympathetic Nervous System, Signal Transduction, Leptin, Receptors, Leptin
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