The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Predicts Mortality in Hemodialysis Patients
Abstract
Tissue advanced glycation end products (AGE) are a measure of cumulative metabolic stress and trigger cytokines driven inflammatory reactions. AGE are thought to contribute to the chronic complications of diabetes and ESRD. Tissue autofluorescence is related to the accumulation of AGE. Therefore, skin autofluorescence (AF) may provide prognostic information on mortality in hemodialysis (HD) patients. Skin AF was measured noninvasively with an AF reader at baseline in 109 HD patients. Overall and cardiovascular mortality was monitored prospectively during a period of 3 yr. The AF reader was validated against AGE contents in skin biopsies from 29 dialysis patients. Forty-two of the 109 (38.5%) HD patients died. Cox regression analysis showed that AF was an independent predictor of overall and cardiovascular mortality (for overall mortality odds ratio [OR] 3.9), as were pre-existing cardiovascular disease (CVD; OR 3.1), C-reactive protein (OR 1.1), and serum albumin (OR 0.3). Multivariate analysis revealed that 65% of the variance in AF could be attributed to the independent effects of age, dialysis and renal failure duration, presence of diabetes, triglycerides levels, and C-reactive protein. AF was also independently linked to the presence of CVD at baseline (OR 8.8; P < 0.001). AF correlated with collagen-linked fluorescence (r = 0.71, P < 0.001), pentosidine (r = 0.75, P < 0.001), and carboxy(m)ethyllysine (both r = 0.45, P < 0.01). Skin AF is a strong and independent predictor of mortality in ESRD. This supports a role for AGE as a contributor to mortality and CVD and warrants interventions specifically aimed at AGE accumulation.
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Cites
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
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Self-citationLowrie, E. G., & Lew, N. L. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70364-5 · Cited by 1,976
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Foley, R. N., Parfrey, P. S., & Sarnak, M. J. (1998) · PubMed · Cited by 1,100
Advanced Glycosylation End Products in Patients with Diabetic Nephropathy
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Self-citationSimple non-invasive assessment of advanced glycation endproduct accumulation
Meerwaldt, R., Graaff, R., Oomen, P. H. N., Links, T. P., Jager, J. J., Alderson, N. L., Thorpe, S. R., Baynes, J. W., Gans, R. O. B., & Smit, A. J. (2004) · Diabetologia · doi:10.1007/s00125-004-1451-2 · Cited by 766
Self-citationOxidative stress in end-stage renal disease: an emerging threat to patient outcome
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Cited by
Advanced glycation end products in the pathogenesis of chronic kidney disease
Rabbani, N., & Thornalley, P. J. (2018) · Kidney International · doi:10.1016/j.kint.2017.11.034 · Cited by 387
Advanced Glycation End-Products (AGEs) and Heart Failure: Pathophysiology and Clinical Implications
Hartog, J. W. L., Voors, A. A., Bakker, S. J. L., Smit, A. J., & van Veldhuisen, D. J. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.09.009 · Cited by 299
Self-citationNutrition and aging skin: Sugar and glycation
Danby, F. W. (2010) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.03.018 · Cited by 107
Da Moura Semedo, C., Webb, M., Waller, H., Khunti, K., & Davies, M. (2017) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2016-134579 · Cited by 81
de Vos, L. C., Lefrandt, J. D., Dullaart, R. P. F., Zeebregts, C. J., & Smit, A. J. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.10.012 · Cited by 77
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Metadata
- Authors
- Meerwaldt, R., Hartog, J. W. L., Graaff, R., Huisman, R. J., Links, T. P., den Hollander, N. C., Thorpe, S. R., Baynes, J. W., Navis, G., Gans, R. O. B., & Smit, A. J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2005-12
- Volume
- 16
- Issue
- 12
- Pages
- 3687-3693
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2163425767
- Cited by
- 396
- References
- 41
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Predicts Mortality in Hemodialysis Patients. https://app.cochat.ai/papers/10.1681/asn.2005020144
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- Meerwaldt, R., Hartog, J. W. L., Graaff, R., Huisman, R. J., Links, T. P., den Hollander, N. C., Thorpe, S. R., Baynes, J. W., Navis, G., Gans, R. O. B., & Smit, A. J. (2005). Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Predicts Mortality in Hemodialysis Patients. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2005020144
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
