Nutrition and aging skin: Sugar and glycation
Abstract
The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements.
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A high-sugar diet, ultraviolet irradiation, and eating barbecued fried foods lead to accumulation of AGEs and acceleration of skin aging.
“A high-sugar diet, ultraviolet irradiation, and eating barbecued fried foods, lead to the accumulation of AGEs and acceleration of skin aging.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [95]
Strict control of blood sugar for four months can reduce production of glycosylated collagen by 25%, and low-sugar food prepared by boiling can also reduce production of AGEs.
“However, strict control of blood sugar for four months can reduce the production of glycosylated collagen by 25%, and low-sugar food prepared by boiling can also reduce the production of AGEs [93,94,95].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [95]
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- Authors
- Danby, F. W.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Danby, F. William
- ORCID
- Danby, F. William
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 28
- Issue
- 4
- Pages
- 409-411
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W2106988709
- Cited by
- 107
- References
- 21
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 12 · 2023: 10 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- skin aging, advanced glycation end products, sugar consumption, glucose, fructose, collagen cross-linking, elastin, ultraviolet radiation, dietary sugar, dietary supplements
- MeSH terms
- Collagen, Elastin, Fructose, Glucose, Humans, Nutritional Physiological Phenomena, Skin, Skin Aging, Glycation End Products, Advanced, Dietary Sucrose
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