High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function
Open accessAbstract
The long-term effects of higher dietary protein intake on cardiovascular and renal outcomes in the general population are not clear. We analyzed data from 8461 individuals who did not have renal disease and participated in two or three subsequent screenings (6.4-yr follow-up) in a prospective, community-based cohort study (Prevention of Renal and Vascular ENd-stage Disease [PREVEND]). We calculated daily protein intake from 24-h urinary urea excretion (Maroni formula) and used Cox proportional hazard models to analyze the associations between protein intake, cardiovascular events, and mortality. We used mixed-effects models to investigate the association between protein intake and change in renal function over time. The mean +/- SD daily protein intake was 1.20 +/- 0.27 g/kg. Protein intake was significantly associated with cardiovascular events during follow-up. The associations seemed U-shaped; compared with intermediate protein intake, individuals with either higher or lower protein intake had higher event rates. All-cause mortality and noncardiovascular mortality also were significantly associated with protein intake; individuals with low protein intake had the highest event rates. We found no association between baseline protein intake and rate of renal function decline during follow-up. In summary, in the general population, high protein intake does not promote accelerated decline of renal function but does associate with an increased risk for cardiovascular events.
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- Authors
- Halbesma, N., Bakker, S. J. L., Jansen, D. F., Stolk, R. P., De Zeeuw, D., De Jong, P. E., & Gansevoort, R. T.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Halbesma, Nynke
- Bakker, Stephan J.L.
- Gansevoort, Ronald T.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2009-08
- Volume
- 20
- Issue
- 8
- Pages
- 1797-1804
- ISSN
- 1046-6673 (ISSN-L)
- PMC
- PMC2723984
- OpenAlex
- W2096852158
- Cited by
- 95
- References
- 30
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 5 · 2020: 14 · 2019: 6 · 2018: 9 · 2017: 2 · 2016: 7 · 2015: 1 · 2014: 5 · 2013: 10 · 2012: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Nierstichting
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- protein intake, cardiovascular events, renal function decline, all-cause mortality, non-cardiovascular mortality, U-shaped relationship, PREVEND cohort, urea excretion, general population
- MeSH terms
- Adult, Cardiovascular Diseases, Dietary Proteins, Female, Humans, Male, Middle Aged, Prospective Studies, Renal Insufficiency
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