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Cited by 214Chronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesRenal and Vascular Pathologies

Glomerular hyperfiltration

Cortinovis, Monica, Perico, Norberto, Ruggenenti, Piero, Remuzzi, Andrea, Remuzzi, Giuseppe·2022·Nature Reviews Nephrology
DOI 10.1038/s41581-022-00559-y
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Abstract

Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the glomerular filtration rate (GFR), and the total GFR is the sum of all single-nephron GFRs. Thus, when the single-nephron GFR is increased in the context of a normal number of functioning nephrons, single glomerular hyperfiltration results in 'absolute' hyperfiltration in the kidney. 'Absolute' hyperfiltration can occur in healthy people after high protein intake, during pregnancy and in patients with diabetes, obesity or autosomal-dominant polycystic kidney disease. When the number of functioning nephrons is reduced, single-nephron glomerular hyperfiltration can result in a GFR that is within or below the normal range. This 'relative' hyperfiltration can occur in patients with a congenitally reduced nephron number or with an acquired reduction in nephron mass consequent to surgery or kidney disease. Improved understanding of the mechanisms that underlie 'absolute' and 'relative' glomerular hyperfiltration in different clinical settings, and of whether and how the single-nephron haemodynamic and related biomechanical forces that underlie glomerular hyperfiltration promote glomerular injury, will pave the way toward the development of novel therapeutic interventions that attenuate glomerular hyperfiltration and potentially prevent or limit consequent progressive kidney injury and loss of function.

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Crossref · 10.1038/s41581-022-00559-y

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264 of 264 references verified0 citation errors · 0 not checkable

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  • NOX4-derived hydrogen peroxide exhibits anti-atherosclerotic effects by smooth muscle cell regulation in diabetic mice.

    “In contrast with this study, NOX4-derived hydrogen peroxide exhibited anti-atherosclerotic effects by smooth muscle cell regulation in diabetic mice (Di Marco et al. 2016; Cortinovis et al. 2022).”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Cortinovis et al. 2022

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Authors
Cortinovis, M., Perico, N., Ruggenenti, P., Remuzzi, A., & Remuzzi, G.
Affiliations
  • Mario Negri Institute for Pharmacological Research (IT)
  • University of Bergamo (IT)
Corresponding author
Remuzzi, Giuseppe
ORCID
Venue
Nature Reviews Nephrology
Publisher
Springer Science and Business Media LLC
Published
2022-04-01
Volume
18
Issue
7
Pages
435-451
ISSN
  • 1745-8323 (ISSN-L)
  • 1759-5061
  • 1759-507X
DOI
10.1038/s41581-022-00559-y
OpenAlex
W4220773194
Cited by
214
References
264
Citations by year
2026: 48 · 2025: 62 · 2024: 48 · 2023: 42 · 2022: 13
FWCI
6.20
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Reviews Nephrology (publishedVersion)
  • PubMed (publishedVersion)
  • Aisberg (University of Bergamo) (submittedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
Keywords
glomerular hyperfiltration, glomerular filtration rate, single nephron glomerular filtration rate, nephron number, glomerular injury, kidney injury, renal protection, protein intake, pregnancy, diabetes mellitus, obesity, polycystic kidney disease
MeSH terms
Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Glomerulus, Nephrons, Pregnancy, Polycystic Kidney, Autosomal Dominant

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