The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Regulated Cell Death in AKI
Open accessAbstract
AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under these conditions, renal tubular cell death may occur by regulated necrosis (RN) or apoptosis. In the last two decades, tubular apoptosis has been shown in preclinical models and some clinical samples from patients with AKI. Mechanistically, apoptotic cell death in AKI may result from well described extrinsic and intrinsic pathways as well as ER stress. Central converging nodes of these pathways are mitochondria, which become fragmented and sensitized to membrane permeabilization in response to cellular stress, resulting in the release of cell death-inducing factors. Whereas apoptosis is known to be regulated, tubular necrosis was thought to occur by accident until recent work unveiled several RN subroutines, most prominently receptor-interacting protein kinase-dependent necroptosis and RN induced by mitochondrial permeability transition. Additionally, other cell death pathways, like pyroptosis and ferroptosis, may also be of pathophysiologic relevance in AKI. Combination therapy targeting multiple cell-death pathways may, therefore, provide maximal therapeutic benefits.
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Cites
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Cited by
Synchronized renal tubular cell death involves ferroptosis
Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126
Self-citationRegulated cell death and inflammation: an auto-amplification loop causes organ failure
Linkermann, A., Stockwell, B. R., Krautwald, S., & Anders, H.-J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3743 · Cited by 522
Self-citationTang, C., Han, H., Yan, M., Zhu, S., Liu, J., Liu, Z., He, L., Tan, J., Liu, Y., Liu, H., et al. (2018) · Autophagy · doi:10.1080/15548627.2017.1405880 · Cited by 309
Self-citationImmune cells and inflammation in AKI to CKD progression
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Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease
Shu, S., Zhu, J., Liu, Z., Tang, C., Cai, J., & Dong, Z. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.006 · Cited by 155
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Metadata
- Authors
- Linkermann, A., Chen, G., Dong, G., Kunzendorf, U., Krautwald, S., & Dong, Z.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2014-12
- Volume
- 25
- Issue
- 12
- Pages
- 2689-2701
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2101800432
- Cited by
- 563
- References
- 31
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- green
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