The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs
Open accessAbstract
Phenotypic changes induced by extracellular vesicles have been implicated in mesenchymal stromal cell-promoted recovery of AKI. MicroRNAs are potential candidates for cell reprogramming toward a proregenerative phenotype. The aim of this study was to evaluate whether microRNA deregulation inhibits the regenerative potential of mesenchymal stromal cells and derived extracellular vesicles in a model of glycerol-induced AKI in severe combined immunodeficient mice. We generated mesenchymal stromal cells depleted of Drosha to alter microRNA expression. Drosha-knockdown cells produced extracellular vesicles that did not differ from those of wild-type cells in quantity, surface molecule expression, and internalization within renal tubular epithelial cells. However, these vesicles showed global downregulation of microRNAs. Whereas wild-type mesenchymal stromal cells and derived vesicles administered intravenously induced morphologic and functional recovery in AKI, the Drosha-knockdown counterparts were ineffective. RNA sequencing analysis showed that kidney genes deregulated after injury were restored by treatment with mesenchymal stromal cells and derived vesicles but not with Drosha-knockdown cells and vesicles. Gene ontology analysis showed in AKI an association of downregulated genes with fatty acid metabolism and upregulated genes with inflammation, matrix-receptor interaction, and cell adhesion molecules. These alterations reverted after treatment with wild-type mesenchymal stromal cells and extracellular vesicles but not after treatment with the Drosha-knockdown counterparts. In conclusion, microRNA depletion in mesenchymal stromal cells and extracellular vesicles significantly reduced their intrinsic regenerative potential in AKI, suggesting a critical role of microRNAs in recovery after AKI.
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Cites
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Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491
Self-citationIsolation, cultivation, and characterization of human mesenchymal stem cells
Mushahary, D., Spittler, A., Kasper, C., Weber, V., & Charwat, V. (2018) · Cytometry Part A · doi:10.1002/cyto.a.23242 · Cited by 599
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Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 503
Merchant, M. L., Rood, I. M., Deegens, J. K. J., & Klein, J. B. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.148 · Cited by 494
Mesenchymal stem cell–derived extracellular vesicles attenuate kidney inflammation
Eirin, A., Zhu, X.-Y., Puranik, A. S., Tang, H., McGurren, K. A., van Wijnen, A. J., Lerman, A., & Lerman, L. O. (2017) · Kidney International · doi:10.1016/j.kint.2016.12.023 · Cited by 320
Metadata
- Authors
- Collino, F., Bruno, S., Incarnato, D., Dettori, D., Neri, F., Provero, P., Pomatto, M., Oliviero, S., Tetta, C., Quesenberry, P. J., & Camussi, G.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2015-10
- Volume
- 26
- Issue
- 10
- Pages
- 2349-2360
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2158686528
- Cited by
- 249
- References
- 7
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Collino, F., Bruno, S., Incarnato, D., Dettori, D., Neri, F., Provero, P., Pomatto, M., Oliviero, S., Tetta, C., Quesenberry, P. J., & Camussi, G. (2015). AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2014070710
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