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Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI
Open accessAbstract
AKI is histologically characterized by necrotic cell death and inflammation. Diverse pathways of regulated necrosis have been reported to contribute to AKI, but the molecular regulators involved remain unclear. We explored the relative contributions of ferroptosis and necroptosis to folic acid (FA)–induced AKI in mice. FA-AKI in mice associates with lipid peroxidation and downregulation of glutathione metabolism proteins, features that are typical of ferroptotic cell death. We show that ferrostatin-1 (Fer-1), an inhibitor of ferroptosis, preserved renal function and decreased histologic injury, oxidative stress, and tubular cell death in this model. With respect to the immunogenicity of ferroptosis, Fer-1 prevented the upregulation of IL-33, an alarmin linked to necroptosis, and other chemokines and cytokines and prevented macrophage infiltration and Klotho downregulation. In contrast, the pancaspase inhibitor zVAD-fmk did not protect against FA-AKI. Additionally, although FA-AKI resulted in increased protein expression of the necroptosis mediators receptor–interacting protein kinase 3 (RIPK3) and mixed lineage domain–like protein (MLKL), targeting necroptosis with the RIPK1 inhibitor necrostatin-1 or genetic deficiency of RIPK3 or MLKL did not preserve renal function. Indeed, compared with wild-type mice, MLKL knockout mice displayed more severe AKI. However, RIPK3 knockout mice with AKI had less inflammation than their wild-type counterparts, and this effect associated with higher IL-10 concentration and regulatory T cell-to-leukocyte ratio in RIPK3 knockout mice. These data suggest that ferroptosis is the primary cause of FA-AKI and that immunogenicity secondary to ferroptosis may further worsen the damage, although necroptosis-related proteins may have additional roles in AKI.
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“A similar protective effect is observed in GPX4-independent models of renal ischemic or toxic injury [540, 592], Parkinson disease [593], and other human pathologies [594].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [592]
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698
Bellomo, R., Kellum, J. A., & Ronco, C. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61454-2 · Cited by 2,607
Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
Kaczmarek, A., Vandenabeele, P., & Krysko, D. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.003 · Cited by 1,411
Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146
Self-citationSynchronized renal tubular cell death involves ferroptosis
Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126
Self-citationLinkermann, A., & Green, D. R. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1310050 · Cited by 1,103
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Seibt, T., Wahida, A., Hoeft, K., Kemmner, S., Linkermann, A., Mishima, E., & Conrad, M. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae097 · Cited by 21
Self-citationThe Hippo pathway and its correlation with acute kidney injury
Zhang, C., 上海交通大学附属第一人民医院肾内科, 上. 2., Li, C., Xu, K., Zheng, Z., Cheng, G., Wu, H., Liu, J., & 复旦大学基础医学院病理科, 上. 2. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.110 · Cited by 18
Targeting and therapeutic peptide-based strategies for polycystic kidney disease
Wang, J., Tripathy, N., & Chung, E. J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.08.011 · Cited by 19
Sugawara, H., Moniwa, N., Kuno, A., Ohwada, W., Osanami, A., Shibata, S., Kimura, Y., Abe, K., Gocho, Y., Tanno, M., et al. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.12.001 · Cited by 19
Zheng, B., Niu, Z., Si, S., Zhao, G., Wang, J., Yao, Z., Cheng, F., & He, W. (2021) · Aging · doi:10.18632/aging.203390 · Cited by 18
Wang, Y., Zhang, J., Wang, Z., Ren, Q., Li, Z., Huang, G., & Wen, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146669 · Cited by 17
Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p/TFR2 axis
Xiong, L., Li, X., Hua, X., & Qian, Z. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04010-1 · Cited by 17
Ultrasmall Nanodots with Dual Anti‐Ferropototic Effect for Acute Kidney Injury Therapy
Zeng, F., Qin, Y., Nijiati, S., Liu, Y., Ye, J., Shen, H., Cai, J., Xiong, H., Shi, C., Tang, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202403305 · Cited by 17
Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation
Chen, H., Chen, L., & Wang, W. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250204 · Cited by 16
Elsayed, M. S. E., Abu‐Elsaad, N., & Nader, M. A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119974 · Cited by 16
Deng, L., Xiao, M., Wu, A., He, D., Huang, S., Deng, T., Xiao, J., Chen, X., Peng, Y., & Cao, K. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c02706 · Cited by 16
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury
Vázquez‐Carballo, C., Herencia, C., Guerrero‐Hue, M., García‐Caballero, C., Rayego‐Mateos, S., Morgado‐Pascual, J. L., Opazo-Ríos, L., González‐Guerrero, C., Vallejo‐Mudarra, M., Cortegano, I., et al. (2022) · The Journal of Pathology · doi:10.1002/path.5995 · Cited by 16
Self-citationQi, H., Deng, F., Wang, Y., Zhang, H., Kanwar, Y. S., & Dai, Y. (2022) · Cells · doi:10.3390/cells12010016 · Cited by 16
Bi, Q., Wu, J., Qiu, X., Li, Y., Yan, Y.-Y., Sun, Z.-J., & Wang, W. (2023) · The EPMA Journal · doi:10.1007/s13167-023-00320-w · Cited by 16
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Pan, C., Zhao, H., Cai, X., Wu, M., Qin, B., & Li, J. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2379601 · Cited by 16
Salama, R. M., Darwish, S. F., Yehia, R., Sallam, A. A., Elmongy, N. F., Abdel-Galil, M., & Wakeel, S. A. E. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.115027 · Cited by 16
Wang, H., Zuo, J., Zha, L., Jiang, X., Wu, C., Yang, Y.-A., Tang, W., & Shi, T. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104755 · Cited by 16
Li, X., Jiang, B., Zou, Y. S., Zhang, J., Fu, Y., & Zhai, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.788977 · Cited by 16
Carnosine attenuates renal ischemia–reperfusion injury by inhibiting GPX4-mediated ferroptosis
Wang, H., Guo, S., Wang, B., Liu, X., Gao, L., Chen, C., & Wu, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110850 · Cited by 16
Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunities
Tan, R., Chen, G., Yan, Y., Guo, H., Han, X., Zhu, Q., & Du, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1511015 · Cited by 15
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Jiang, M., Wu, S., Xie, K., Zhou, G., Zhou, W., & Bao, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35882 · Cited by 17
Khawas, S., & Sharma, N. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05062-5 · Cited by 16
Liu, W., Xiong, Z., Fu, T., Yang, J., Zou, J., Wu, Y., Kuang, L., Wang, Q., Li, S., & Le, A. (2024) · Biology Direct · doi:10.1186/s13062-024-00515-9 · Cited by 15
Dizaji, R., Sharafi, A., Pourahmad, J., Abdollahifar, M., Vatanpour, H., & Hosseini, M.-J. (2019) · Toxicon · doi:10.1016/j.toxicon.2019.03.011 · Cited by 15
Signal pathways involved in contrast-induced acute kidney injury
Deng, K., Pei, M., Li, B., Yang, N., Wang, Z. L., Wan, X., Zhong, Z., Yang, Z., & Chen, Y. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1490725 · Cited by 14
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Self-citationTargeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects
Zhang, J., Tong, J., Sun, D., Fu, J., Li, D., & Wang, P. (2023) · Medicinal Research Reviews · doi:10.1002/med.21934 · Cited by 14
Chen, W., Li, L., Wu, Y., Yang, J., & Tzeng, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041544 · Cited by 14
Wang, H., Sun, J., Luo, Y., Li, X., & Li, J. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2536732 · Cited by 13
Progress and Setbacks in Translating a Decade of Ferroptosis Research into Clinical Practice
von Samson‐Himmelstjerna, F. A., Kolbrink, B., Riebeling, T., Kunzendorf, U., & Krautwald, S. (2022) · Cells · doi:10.3390/cells11142134 · Cited by 15
Guerrero‐Mauvecin, J., Fontecha‐Barriuso, M., López-Diaz, A. M., Ortíz, A., & Sanz, A. B. (2023) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2023.04.006 · Cited by 13
Self-citationChattopadhyay, S., Hazra, R., Mallick, A., Gayen, S., & Roy, S. (2024) · Immunology · doi:10.1111/imm.13789 · Cited by 13
Long, S.-W., Li, S., Li, J., He, Y., Bo, T., Jing, H.-H., Zheng, W., & Wu, J. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01872-0 · Cited by 13
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Li, Q., Liu, F., Xiaoxiao, T., Fu, H., & Mao, J. (2021) · Kidney Diseases · doi:10.1159/000520141 · Cited by 14
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Zhang, L.-L., Tang, R., & Yang, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.964034 · Cited by 14
C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene-sensitization mice
Liu, Z., Ma, J., Zuo, X., Zhang, X., Hong, Y., Cai, S., Huang, H., Wang, F., Wu, C., Zhang, J., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114020 · Cited by 13
Identification of a ferroptosis-related lncRNA signature with prognosis for Wilms tumor
Liu, H., Zhang, M., Zhang, T., Shi, M., Lu, W., Yang, S., Cui, Q., & Li, Z. (2021) · Translational Pediatrics · doi:10.21037/tp-21-211 · Cited by 13
Research progress of ferroptosis in acute kidney injury
Zhang, L., Luo, F., Yuan, N., Yin, J., Shen, B., Chai, Y., Sun, L., Wang, X., Yin, L., & Luo, C. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1614156 · Cited by 13
Liu, J., Zeng, D., Wang, Y., Deng, F., & Deng, Z. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146096 · Cited by 12
Wei, S., Fu, Y., Zeng, Y., Wu, W., Cai, J., & Dong, Z. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108930 · Cited by 12
Li, J., Jiang, Y., Dai, Q., Yu, Y., Lv, X., Zhang, Y., Liao, X., Ao, L., Hu, G., Meng, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1043945 · Cited by 12
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Yang, J., Yan, C., Chen, S., Li, M., Miao, Y., Ma, X., Zeng, J., & Xie, P. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1380992 · Cited by 12
Wang, Y., Shen, Z., Mo, S., Zhang, H., Chen, J., Zhu, C. G., Lv, S., Zhang, D., Huang, X., Gu, Y., et al. (2024) · Human Cell · doi:10.1007/s13577-024-01072-z · Cited by 13
The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets
Yu, Y., Zhang, L., Zhang, D., Dai, Q., Hou, M., Chen, M., Gao, F., & Liu, X. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05056-3 · Cited by 12
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Guo, Z., Zhuang, H., & Shi, X. (2024) · Oncology Letters · doi:10.3892/ol.2024.14697 · Cited by 13
Li, Q., Shi, X. Y., Huang, H., Gao, Q., Sun, Q., Meng, Y., Niu, L., Xie, C., & Yang, C. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119359 · Cited by 12
Lv, L., Hu, M., Li, J., Guo, R., He, M., Zhou, P., Lei, Y., Chen, M., Liu, Z., & Zhou, S. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.039 · Cited by 12
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Soriano‐Castell, D., Liang, Z., Maher, P. A., & Currais, A. J. M. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15517 · Cited by 12
Cuevas-López, B., Romero-Ramirez, E. I., García‐Arroyo, F. E., Tapia, E., León‐Contreras, J. C., Silva‐Palacios, A., Roldán, F., Medina‐Campos, O. N., Hernández‐Esquivel, L., Marín‐Hernández, Á., et al. (2023) · Antioxidants · doi:10.3390/antiox12081592 · Cited by 11
Yang, X., Dong, S., Fan, Y., Xia, Y., Yang, F., Chen, Z., Chen, D., Zhang, M., Liang, D., & Zeng, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914530 · Cited by 11
Sheng, Z., Yu, Z., Wang, M., Zhou, R., Chen, S., Yu, X., & Li, F. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101608 · Cited by 12
Regulated cell death in chronic kidney disease: current evidence and future clinical perspectives
Giuliani, K. T. K., Adams, B. C., Healy, H. G., & Kassianos, A. J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1497460 · Cited by 11
Zhang, Z., Zhao, Z., Qi, C., Zhang, X., Xiao, Y., Chen, C., Zou, Y. S., Chen, X., Gu, L., Huang, J., et al. (2025) · MedComm · doi:10.1002/mco2.70064 · Cited by 11
Rousselle, A., Lodka, D., Sonnemann, J., Kling, L., Kettritz, R., & Schreiber, A. (2025) · Kidney International · doi:10.1016/j.kint.2025.02.023 · Cited by 11
Iron Metabolism and Ferroptosis in Diabetic Kidney Disease
Mu, F., Luo, P., Zhu, Y., Nie, P., Li, B., & Bai, X. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70067 · Cited by 11
Li, B., Lin, F., Song, B., Han, S., Ye, Z., Sun, Y., Wang, P., Xia, Y., Yu, W., Zhou, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62433-2 · Cited by 11
Boyd, P., & Hyde, D. R. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.108947 · Cited by 11
Yang, X., & Guo, N. (2023) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-023-00814-x · Cited by 11
Tian, F.-Y., Liu, K., Tang, Z.-Y., Zhou, G., Zhou, G.-L., Chen, R.-F., Liu, H.-B., Fang, W., Zuo, X., & Zhou, L. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2548613 · Cited by 10
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Targeting ferroptosis by natural products in pathophysiological conditions
Zheng, D., Jin, S., Liu, P.-S., Ye, J., & Xie, X. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03812-4 · Cited by 10
Xie, Z., Hou, Q., He, Y., Xie, Y., Mo, Q., Wang, Z., Zhao, Z., Chen, X., Peng, T., Li, L., et al. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037315874240826112422 · Cited by 11
Duan, Z., Zheng, J., Huang, S., & HU, L. (2024) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12898 · Cited by 10
Liu, X., Zhou, Y., Lu, Z., Yang, F., Wang, Y., Zhang, S., Zhang, J., Zou, H., & Lin, M. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s486286 · Cited by 10
Ferroptosis Activation Contributes to Kidney Aging in Mice by Promoting Tubular Cell Senescence
Wang, Z., Dai, Y., Jin, R., Mo, D., Hu, Q., Huang, Y., Zhang, L., Zhang, C., Gao, H., & Qi, Y. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf042 · Cited by 10
Wu, J., Sun, Z., Bi, Q., & Wang, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.815223 · Cited by 10
Shan, K., Li, J., Yang, Q., Chen, K., Zhou, S., Jia, L., Fu, G., Qi, Y., Wang, Q., & Chen, Y. Q. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109418 · Cited by 10
Zhou, F., Yang, Y., Luo, L., Chen, Y., Luo, Q., & Chen, J. (2020) · BioMed Research International · doi:10.1155/2020/6097516 · Cited by 10
Targeting of regulated necrosis in kidney disease
Martín‐Sánchez, D., Poveda, J., Fontecha‐Barriuso, M., Ruiz‐Andrés, O., Sánchez-Niño, M. D., Ruiz‐Ortega, M., Ortíz, A., & Sanz, A. B. (2018) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2018.02.004 · Cited by 10
Self-citationRenal transporter OAT1 and PPAR ‐α pathway co‐contribute to icaritin‐induced nephrotoxicity
Wang, D., Liu, J., Chen, X., Chen, J., Zhao, T., Du, J., Wang, C., Meng, Q., Sun, H., Wang, F., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7633 · Cited by 9
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Fontecha‐Barriuso, M., Villar-Gómez, N., Guerrero‐Mauvecin, J., Martinez-Moreno, J. M., Carrasco, S., Martín‐Sánchez, D., Rodríguez‐Laguna, M., Gómez, M. J., Sánchez-Niño, M. D., Ruiz‐Ortega, M., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6355 · Cited by 9
Self-citationLi, Y., Zhang, J., Qiu, X., Zhang, Y., Wu, J., Bi, Q., Sun, Z., & Wang, W. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2435487 · Cited by 9
Yang, Y., Wang, P., Zhou, K., Zhang, W., Liu, S., Ouyang, J., Bai, M., Ding, G., Huang, S., Jia, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202412250 · Cited by 9
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Cheng, Z., Wang, K., Wang, Y., Liu, T., Li, J., Wang, Y., Chen, W., Awuti, R., Zhou, H., Tong, W., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07882-9 · Cited by 9
Zhang, D., Liu, S., Jiang, H., Liu, S., & Kong, F. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.110878 · Cited by 9
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Zuo, J., Wang, S., Jiang, X., Cao, M., Zhang, Z., Shi, T., Qin, H., & Tang, W. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104455 · Cited by 9
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Zhang, W., Yang, L., Jin, Z., Zhang, S., Zhu, F., Li, Z., & Yu, M. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111220 · Cited by 8
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Retracted
Metadata
- Authors
- Martin-Sanchez, D., Ruiz-Andres, O., Poveda, J., Carrasco, S., Cannata-Ortiz, P., Sanchez-Niño, M. D., Ruiz Ortega, M., Egido, J., Linkermann, A., Ortiz, A., & Sanz, A. B.
- Affiliations
- Division of Nephrology and
- Department of Pathology, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz and
- Christian-Albrechts-Universität zu Kiel (DE)
- Corresponding author
- Poveda, Jonay
- Carrasco, Susana
- Linkermann, Andreas
- Sanz, Ana B.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2016-06-27
- Volume
- 28
- Issue
- 1
- Pages
- 218-229
- ISSN
- 1046-6673 (ISSN-L)
- 1533-3450
- PMC
- PMC5198282
- OpenAlex
- W2470889344
- Cited by
- 564
- References
- 37
- Citations by year
- 2026: 44 · 2025: 72 · 2024: 84 · 2023: 79 · 2022: 99 · 2021: 65 · 2020: 46 · 2019: 31 · 2018: 31 · 2017: 13
- FWCI
- 24.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- ferroptosis, necroptosis, acute kidney injury, folic acid nephrotoxicity, ferrostatin-1, regulated necrosis, lipid peroxidation, glutathione metabolism, IL-33, RIPK3, MLKL, necrostatin-1, Klotho, macrophage infiltration, renal inflammation, oxidative stress, regulatory T cells
- MeSH terms
- Animals, Folic Acid, Iron, Mice, Inbred C57BL, Necrosis, Cell Death, Mice, Acute Kidney Injury
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