Cited by 566Acute Kidney Injury ResearchFerroptosis and cancer prognosisCell death mechanisms and regulation

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

Open access

Martin-Sanchez, Diego, Ruiz-Andres, Olga, Poveda, Jonay, Carrasco, Susana, Cannata-Ortiz, Pablo, Sanchez-Niño, Maria D., Ruiz Ortega, Marta, Egido, Jesus, Linkermann, Andreas, Ortiz, Alberto, Sanz, Ana B.·2017·Journal of the American Society of Nephrology

DOI 10.1681/asn.2015121376PMC PMC5198282

Open this paper in CoChat — free account

Abstract

AKI is histologically characterized by necrotic cell death and inflammation. Diverse pathways of regulated necrosis have been reported to contribute to AKI, but the molecular regulators involved remain unclear. We explored the relative contributions of ferroptosis and necroptosis to folic acid (FA)–induced AKI in mice. FA-AKI in mice associates with lipid peroxidation and downregulation of glutathione metabolism proteins, features that are typical of ferroptotic cell death. We show that ferrostatin-1 (Fer-1), an inhibitor of ferroptosis, preserved renal function and decreased histologic injury, oxidative stress, and tubular cell death in this model. With respect to the immunogenicity of ferroptosis, Fer-1 prevented the upregulation of IL-33, an alarmin linked to necroptosis, and other chemokines and cytokines and prevented macrophage infiltration and Klotho downregulation. In contrast, the pancaspase inhibitor zVAD-fmk did not protect against FA-AKI. Additionally, although FA-AKI resulted in increased protein expression of the necroptosis mediators receptor–interacting protein kinase 3 (RIPK3) and mixed lineage domain–like protein (MLKL), targeting necroptosis with the RIPK1 inhibitor necrostatin-1 or genetic deficiency of RIPK3 or MLKL did not preserve renal function. Indeed, compared with wild-type mice, MLKL knockout mice displayed more severe AKI. However, RIPK3 knockout mice with AKI had less inflammation than their wild-type counterparts, and this effect associated with higher IL-10 concentration and regulatory T cell-to-leukocyte ratio in RIPK3 knockout mice. These data suggest that ferroptosis is the primary cause of FA-AKI and that immunogenicity secondary to ferroptosis may further worsen the damage, although necroptosis-related proteins may have additional roles in AKI.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1681/asn.2015121376

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698
Acute kidney injury
Bellomo, R., Kellum, J. A., & Ronco, C. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61454-2 · Cited by 2,607
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
Kaczmarek, A., Vandenabeele, P., & Krysko, D. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.003 · Cited by 1,411
Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146
Self-citation
Synchronized renal tubular cell death involves ferroptosis
Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126
Self-citation
Necroptosis
Linkermann, A., & Green, D. R. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1310050 · Cited by 1,103
Self-citation

Show all 37 references

Sorted by citations

Items 501–566 of 566

Antioxidant Potential and Oxidative Stress Modulation of Geranium macrorrhizum L. Oil Extract in Gentamicin-Induced Nephrotoxicity
Georgiev, T., Nikolova, G., Dyakova, V., Zlateva, S., Karamalakova, Y. D., Georgieva, E., Petkova-Parlapanska, K., Ananiev, J. R., Dobreva, A. M., & Hadzhibozheva, P. (2025) · Pharmaceuticals · doi:10.3390/ph18091283 · Cited by 1
ACSL4 mediates ferroptosis to promote immunoglobulin A nephropathy progression: scRNA-seq analysis
Shao, N., Tan, K., Chen, P., & Luo, Q. (2026) · Scientific Reports · doi:10.1038/s41598-026-43023-8 · Cited by 1
Irisin alleviates ferroptosis in LPS-induced acute kidney injury via regulating FGL2
Yin, S., Wang, Y., Huang, D., Quan, Z., & Tao, R. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117870 · Cited by 1
Kidney protective bioactivity guided investigation for isolation and mechanism of sulfated heterpolysaccharide from Laminarina japonica
Cai, M., Gao, K., Huang, H., He, X., Jiang, D., Jin, W., & Zhong, W. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.10.009 · Cited by 1
#1385 Dipeptidyl-peptidase-4 inhibitor teneligliptin attenuates folic acid-induced tubular cell death via inhibiting ferroptosis
Yasuda, H., Ema, C., & Iwakura, T. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae069.1102 · Cited by 1
Isoliquiritigenin attenuates LPS-induced acute kidney injury through suppression of HMGB1 pathway in renal tubular against ferritinophagyPreprint
Tang, Y., Wang, Y., Wang, C., Yu, M., Li, L., Chen, S., Li, G., Wang, L., Xie, M., & Li, Y. (2020) · doi:10.21203/rs.2.24196/v1 · Cited by 1
Identification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technologyPreprint
Shi-Wei, L., Shi-Hong, L., Jian, L., Bo, T., Hao-Han, J., Wei, Z., & Juan, W. (2023) · Research Square · doi:10.21203/rs.3.rs-3080196/v1 · Cited by 1
Assessment of In Vivo Kidney Cell Death: Glomerular Injury
Tonnus, W., Al-Mekhlafi, M., Gembardt, F., Hugo, C., & Linkermann, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8754-2_14
Self-citation
Urine Neutrophil Gelatinase-Associated Lipocalin Measured at Admission to Predict Recovery from Acute Kidney Injury of Vietnamese ICU Patients
Thang, L. V., Trung, K. N., Tuan, P. N. H., Dung, N. T. T., Kien, T. Q., Ha, D. M., Toan, P. Q., Hà, N. T. T., Vân, D. T., Duc, N. V., et al. (2019) · The Open Urology & Nephrology Journal · doi:10.2174/1874303x01912010060
Recapitulating Parkinson’s disease pathology in a three-dimensional neural cell culture model
Taylor-Whiteley, T. R. (2019) · Sheffield Hallam University · doi:10.7190/shu-thesis-00321
Ejes inflamatorios y alarminas en el intestino delgado en enfermedad celíaca
Pérez, F. (2021) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/129881
Peer Review #3 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.1/reviews/3
Peer Review #1 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.1/reviews/1
Peer Review #2 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.2/reviews/2
Peer Review #2 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.1/reviews/2
Ana Hatları ile Ferroptozis
Gezer, A., & SARI, E. K. (2022) · Turkish Veterinary Journal · doi:10.51755/turkvetj.1078397
Ginsenoside Rb1 ameliorates renal tubular epithelial cells ferroptosis in AKIPreprint
Wu, Z., Deng, J., Tao, C., Tan, W., Lin, L., Zheng, L., Yang, X., Li, K., & Yang, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1997782/v1
Clinical significance of ferroptosis as iron-dependent regulated cell death in the general structure of the disease
Lezhenko, G. O., Абатуров, А. Е., & Pogribna, A. O. (2022) · CHILD`S HEALTH · doi:10.22141/2224-0551.17.4.2022.1518
Senescent cell accumulation & Research-based undergraduate education
Valentijn, F. A. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1121
Analysis and Validation of Antineutrophil cytoplasmic antibody-associated vasculitis with renal injury of the ferroptosis-related gene CD44 and Pan-CancerPreprint
Tao, M., Zeng, Z., He, Y., Li, Y., Liao, W., Nie, H., & Gao, P. (2022) · Research Square · doi:10.21203/rs.3.rs-2342623/v1
Ganoderma lucidum Polysaccharide Prevented Ferroptosis in Diabetes Nephropathy by Inhibiting IL-1 and Enhancing Nrf2
徐, 顺. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13102228
The Hippo Coactivator TAZ Exacerbates Cisplatin-Induced Acute Renal Injury
Xue, X., Zhu, X., Zhou, L., Sun, X., Gu, M., Liang, Y., Tan, M., Hou, Q., Wang, S., & Dai, C. (2024) · Kidney Diseases · doi:10.1159/000540973
Ferroptosis exacerbates myocardial ischemia-reperfusion injury via worsening oxidative stress and inflammatory responses: the role of Ferritin/SLC7A11/GPX-4 signaling pathwayPreprint
Wang, L., Li, D., & Zhi, J. (2024) · Research Square · doi:10.21203/rs.3.rs-5312142/v1
Mechanisms of Toxicant-Induced Acute Kidney Injury
Cummings, B. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00124-8
#2099 Teneligliptin alleviates acute kidney injury by exerting anti-ferroptotic effects on renal tubules
Ema, C., Iwakura, T., Okazaki, K., & Yasuda, H. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaf116.0948
Verbenalin attenuates renal tubular epithelial ferroptosis in ischemia–reperfusion injury induced AKI by regulating the HIF-1α/HO-1 signaling pathway
Xu, Z., Li, Y., Jiang, X., Tai, F.-Y., Li, M., Zhao, R.-F., Wang, X., & He, Y.-X. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04643-w
Systems-Based Metabolomics and Network Pharmacology Reveal MAOA-Dependent Anti-Ferroptotic Mechanisms of Curcumin in Acute Kidney Injury
Dimitrova, K., & Slavov, T. (2023) · Pharmaceutical Sciences and Drug Design · doi:10.51847/hskwd6pl4l
Additional file 7 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909791
Additional file 5 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909785
Additional file 4 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909782
Additional file 1 of Identification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technology
Long, S.-W., Li, S.-H., Li, J., He, Y., Tan, B., Jing, H.-H., Zheng, W., & Wu, J. (2024) · Figshare · doi:10.6084/m9.figshare.25670147
Additional file 2 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909776
Additional file 3 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909779
Additional file 1 of Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p/TFR2 axis
Xiong, L., Li, X., Hua, X., & Qian, Z. (2023) · Figshare · doi:10.6084/m9.figshare.23730832
Additional file 2 of Identification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technology
Long, S.-W., Li, S.-H., Li, J., He, Y., Tan, B., Jing, H.-H., Zheng, W., & Wu, J. (2024) · Figshare · doi:10.6084/m9.figshare.25670355
Additional file 1 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909773
Additional file 6 of Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16909788
Morroniside in Cornus officinalis Sieb. et Zucc. protects renal tubular epithelial cells from hypoxia/reoxygenation damage by inhibiting oxidative stress and ferroptosis
Wang, X., & Huang, F. (2025) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.25-124
The Role of Iron and Ferroptosis in the Pathogenesis of L-Arginine-Induced Acute Pancreatitis
Zhang, P., Fan, L., Teng, M., Wu, Q., Jiaqing, W., & Korotkova, I. P. (2025) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-026-06550-y
Exploring micronutrient diets in renal disease through metabolomics: a comprehensive review
Sharma, N., Yadav, P., Sharma, S., Srivastava, S., Kurmi, R. K., & Yadav, T. (2026) · Nutrire · doi:10.1186/s41110-025-00417-4
A missense mutation in acyl-CoA synthetase ACSL4 reveals essential residues for catalytic activity in ferroptosis
Sei, H., Ando, H., Nakashima, F., Takahara, T., Kita, M., Yamada, K.-I., Uchida, K., & Shibata, T. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111232
Cell death assays for the detection of acute kidney tubular necrosis
Maremonti, F., & Linkermann, A. (2026) · Methods in cell biology · doi:10.1016/bs.mcb.2026.01.016
Self-citation
Cell death in kidney transplantation: Mechanisms and therapeutic perspectives
Zhang, Z., Wang, M., & Cai, M. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119236
L'alarmine IL-33, un médiateur clé des phénomènes d'ischémie-reperfusion rénale mettant en jeu les cellules iNKT
Ferhat, M. (2017) · theses.fr (ABES) · doi:10.70675/3ef120eaz1e3bz43a3za462zcc11473e8836
Les rôles tubulaires et macrophagiques de la périostine dans les maladies rénales aigues
Kormann, R. (2018) · doi:10.70675/e7200627za1dbz4d4ezbd37zcd1b9fd4c6b3
Characterising the role of alpha synuclein in Ferroptosis, in the context of Parkinson's Disease
Mahoney‐Sanchez, L. (2022) · theses.fr (ABES) · doi:10.70675/a7f080d0z9ffaz4e1ez9550z0e29c4958e66
Biomarqueurs du microenvironnement tumoral pour la stratification thérapeutique des cancers tête et cou
Lailler, C. (2021) · theses.fr (ABES) · doi:10.70675/156d914aze7c5z424cz8478z47ab5e54396f
Rôle du métabolisme des acides gras polyinsaturés et du fer dans la vulnérabilité des neurones dopaminergiques à la ferroptose : nouvelles approches pharmacologiques pour la maladie de Parkinson.
Bouchaoui, H. (2024) · theses.fr (ABES) · doi:10.70675/e68098e9z03c2z494bza798zfc26b3eb872c
Integrated multi-omics analysis reveals NRF2-dependent ferroptosis regulation underlying the renoprotective effects of p-coumaric acid in folic acid–induced AKI
Ma, H., Shen, N., Liu, X., Zhou, F., Hao, C., & Luo, Q. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112114
Pathophysiology of acute kidney injury
Lever, J. M., & Agarwal, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-815389-5.00057-5
Nephrotoxicity of Fumonisin B1 and Ochratoxin A co-exposure is associated with Hippo/YAP1-mediated ferroptosis
Wang, Q., Quan, L., Tang, J., Zeng, J., Wang, M., Huang, K., Chen, X., & Gan, F. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120294
Bufalin post-transcriptionally suppresses STAT3 to alleviate renal ferroptosis and tubulointerstitial fibrosis in diabetic kidney disease
Qiao, Y., Gao, C., Ji, J., Zuolin, L. I., Shi, H., Ruilian, Y., Sun, J., Wang, Y., Lin, Q., & Zhang, A. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2667591
Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidant N -acetyl cysteine
Kandel, R., Roy, P., Warraich, I. I., & Singh, K. P. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00746.2025
Salvianolic Acid B Protects Against Contrast‐Induced Acute Kidney Injury by Attenuating Ferroptosis via the SIRT1 /Nrf2 Pathway
Yuan, H., Shi, X., Qin, J., Wang, Y., Yuan, Y., Zhang, Y., Wang, Y., Zhang, C., Zhu, J., Chen, L., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202600450rr
Serum Response Factor Regulates CCN1 to Exacerbate Acute Kidney Injury Through Facilitation of Ferroptosis‐Related Injury
Wang, Y., Chen, G., Li, C., Jiang, W., Luan, H., Luo, C., Bu, Q., Zhou, H., Zhang, W., Wang, L., et al. (2026) · Nephrology · doi:10.1111/nep.70244
Spasmolytic Polypeptide‐Expressing Metaplasia in Chronic Atrophic Gastritis and Its Role in the Progression From Gastritis to Gastric Cancer
Quan, X., Ji, L., He, T., Liu, J., Shi, L., & Liu, L. (2026) · Journal of Digestive Diseases · doi:10.1111/1751-2980.70060
6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes
Wen, Y., Fang, P., Qi, Z., Li, M., Liu, X., Zou, Y., Wang, M., Gao, M., & Jing, J. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120603
Beyond the alarm: unveiling the multifaceted role of IL-33 in kidney disease
Yang, M., Miao, S., Yu, M., Fu, X., & Qin, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1887953
Ferroptosis as a target mechanism in heart and kidney disease
Singh, S. J., Cheema, B. S., & Ardehali, H. (2026) · Journal of Clinical Investigation · doi:10.1172/jci202823
Rational Nanomaterial Design for Ferroptosis Modulation: Bidirectional Therapeutic Strategies in Cancer and Beyond
Zhu, Z., Jiang, L., Sun, T., Chen, X., Chen, H., & Li, J. (2026) · ACS Nano · doi:10.1021/acsnano.6c10760
Ferroptosis in kidney disease
Wang, T., Sun, S., Linkermann, A., Min, J., & Wang, F. (2026) · Nature Reviews Nephrology · doi:10.1038/s41581-026-01131-8 · Cited by 1
Self-citation
Flow Cytometry and AI-Driven Biomarker Discovery in Acute Kidney Injury: From Mechanistic Insights to Translation Applications in Clinical and Austere Environments
Jiang, S., Meledeo, M. A., Wu, X., Christy, B. A., & Horseman, T. S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198450
MenSC-EV-derived HSPA5 activates the AKT/mTOR axis to suppress ferroptosis in type 1 diabetes mellitus-associated ovarian dysfunction
Zhang, S., Liu, Q., Chen, B., Chang, H., Pan, Y., Liu, Y., Zhao, X., & Lin, J. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.10.019
Iron and acute kidney injury: potential biomarkers for diagnosis and therapy
Shi, Z., Zhang, C., Yan, C., Tian, M., Zeng, X., Xie, T., Zhao, D., Zhou, X., Wu, Q., Zhang, S., et al. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag119
BindingDB Entry 50013026: Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model.
BindingDB (2022) · UC San Diego · doi:10.7270/q2qn6bht
Gut microbiota-derived indole-3-lactic acid attenuates renal ischemia-reperfusion injury through AhR-modulated oxidative stressPreprint
zheng, J., sun, Q., Yang, X., Shi, X., yang, L., Xu, H., Li, Z., yu, Y., Li, W., Shangguan, W., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10837970/v1

Authors: Martin-Sanchez, D., Ruiz-Andres, O., Poveda, J., Carrasco, S., Cannata-Ortiz, P., Sanchez-Niño, M. D., Ruiz Ortega, M., Egido, J., Linkermann, A., Ortiz, A., & Sanz, A. B.
Affiliations: Division of Nephrology and
Department of Pathology, Instituto de Investigacion Sanitaria (IIS)-Fundacion Jimenez Diaz and
Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author: Poveda, Jonay
Carrasco, Susana
Linkermann, Andreas
Sanz, Ana B.
ORCID: Poveda, Jonay
Carrasco, Susana
Linkermann, Andreas
Sanz, Ana B.
Venue: Journal of the American Society of Nephrology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-06-27
Volume: 28
Issue: 1
Pages: 218-229
ISSN: 1046-6673 (ISSN-L)
1533-3450
DOI: 10.1681/asn.2015121376
PMC: PMC5198282
OpenAlex: W2470889344
Cited by: 564
References: 37
Citations by year: 2026: 44 · 2025: 72 · 2024: 84 · 2023: 79 · 2022: 99 · 2021: 65 · 2020: 46 · 2019: 31 · 2018: 31 · 2017: 13
FWCI: 24.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of the American Society of Nephrology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: ferroptosis, necroptosis, acute kidney injury, folic acid nephrotoxicity, ferrostatin-1, regulated necrosis, lipid peroxidation, glutathione metabolism, IL-33, RIPK3, MLKL, necrostatin-1, Klotho, macrophage infiltration, renal inflammation, oxidative stress, regulatory T cells
MeSH terms: Animals, Folic Acid, Iron, Mice, Inbred C57BL, Necrosis, Cell Death, Mice, Acute Kidney Injury

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks