Necroptosis
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Cell death is regulated by a variety of mechanisms. This review focuses on one of the more recently identified forms of programmed cell death, necroptosis, and its role in normal and disease states. This pathway provides new targets for therapeutic intervention.
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Necroptosis critically depends on sequential activation of RIPK3 and MLKL.
“At the molecular level, necroptosis critically depends on the sequential activation of RIPK3 and mixed lineage kinase domain like pseudokinase (MLKL) [434, 435].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [434]
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- Authors
- Linkermann, A., & Green, D. R.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-01-30
- Volume
- 370
- Issue
- 5
- Pages
- 455-465
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4035222
- OpenAlex
- W4242587027
- Cited by
- 1,103
- References
- 86
- Citations by year
- 2026: 49 · 2025: 69 · 2024: 69 · 2023: 92 · 2022: 119 · 2021: 112 · 2020: 88 · 2019: 89 · 2018: 107 · 2017: 84 · 2016: 92 · 2015: 81 · 2014: 51
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA169291)
- National Institute of Allergy and Infectious Diseases (R01AI044828)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- necroptosis, programmed cell death, regulated cell death, cell death pathways, therapeutic target
- MeSH terms
- Humans, Inflammation, Necrosis, Signal Transduction, Reperfusion Injury, Apoptosis, Metabolic Networks and Pathways
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