Nutrients as novel therapeutic approaches for metabolic disturbances in polycystic ovary syndrome
Open accessAbstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women. This disease is characterized by infertility, menstrual dysfunction, and hyperandrogenism. Also, PCOS is often associated with hyperlipidemia and impaired glucose tolerance, conditions that are associated with cardiovascular disorder, type 2 diabetes, cancer and hypertension. Evidence supports that some nutrients may affect the hormonal and metabolic disturbances of PCOS. Here in this study, we aimed to review the available literature that assessed the nutrients such as inostol, isoflavonids, resveratrol, vitamin D, and PUFA (polyunsaturated fatty acids), known to influence the hormonal and metabolic disturbances of PCOS, along with the strategies and future directions of nutrient supplementations in such patients.
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Mansour et al. found that inositol, omega-3 fatty acids, vitamin D, and resveratrol increase hormonal balance and insulin sensitivity in PCOS patients.
“Mansour et al. pointed out that inositol, omega-3 fatty acids, vitamin D, and resveratrol increase hormonal balance and insulin sensitivity in PCOS patients [65].”
From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [65]
The Inositol and PUFA sections report improved hormonal measures and insulin resistance in women with PCOS. The Vitamin D section describes some potential benefits but also reports trials finding no improvement in insulin sensitivity. The Resveratrol section says no trial had yet examined its effects on PCOS outcomes, so the claim that all four nutrients increase hormonal balance and insulin sensitivity in PCOS patients overstates the review. (LLM, conf=0.90)
Experimental — accuracy not yet measuredCertain nutrients are activators of important metabolic pathways involved in PCOS, such as insulin resistance, hyperlipidemia, oxidative stress, and inflammation, providing possible medical means for treating the condition.
“Certain nutrients have been found to be activators of important metabolic pathways involved in PCOS, such as insulin resistance hyperlipidemia, oxidative stress, and inflammation, thus providing some possible medical means for treating the condition [65].”
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- Authors
- Mansour, A., Hosseini, S., Larijani, B., & Mohajeri-Tehrani, M. R.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Endocrinology and Metabolism Clinical Sciences Institute (IR)
- Venue
- IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- Publisher
- IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
- Published
- 2016
- Volume
- 15
- Pages
- 551-564
- ISSN
- 1611-2156 (ISSN-L)
- PMC
- PMC5225686
- OpenAlex
- W2582109020
- Cited by
- 15
- References
- 78
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 6
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- diamond
- www.excli.de
- Licence
- cc-by
- Locations
- EXCLI journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Technische Universität Dortmund Eldorado (Technische Universität Dortmund) (submittedVersion, cc-by)
- Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo)
- Technische Universität Dortmund Eldorado (Technische Universität Dortmund) (cc-by)
- PubMed
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, nutrients, dietary supplementation, myo-inositol, isoflavonoids, resveratrol, vitamin D, polyunsaturated fatty acids, hyperandrogenism, insulin resistance, hyperlipidemia, metabolic disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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