Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis
Abstract
Purpose To assess the effectiveness and safety of myoinositol for patients with PCOS.Methods In this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primary outcomes included total testosterone, estradiol (E2) and the homeostatic model assessment (HOMA) of insulin resistance.Result Ten trials involving 573 patients were included. The meta-analysis results show that: compared with the control group, myoinositol may improve HOMA index (WMD -0.65; 95% CI -1.02, -0.28; P = 0. 0005) and increase the E2 level (WMD 16.16; 95% CI 2.01, 30.31; P = 0. 03); while there is no enough strong evidence that the myoinositol has an effect on the total testosterone level (WMD -16.11; 95% CI -46.08, 13.86; P = 0. 29).Conclusion Based on current evidence, myoinositol may be recommended for the treatment of PCOS with insulin resistance, as well as for improving symptoms caused by decreased estrogen in PCOS.
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In the myo-inositol vs. metformin or estrogen subgroup, there is not enough strong evidence that myo-inositol improves hyperinsulinemia (WMD −0.99; 95% CI −2.43, 0.45; p = 0.19).
“In the myo-inositol vs. placebo subgroup, myo-inositol is likely to improve hyperinsulinemia because of the lower fasting insulin (WMD −3.97; 95% CI −5.76, −2.18; p < 0.00001), while in the myo-inositol vs. metformin or estrogen subgroup, there is not enough strong evidence (WMD −0.99; 95% CI −2.43, 0.45; p = 0.19).”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [87]
In each subgroup, there is not enough strong evidence that myo-inositol has an effect on fasting glucose.
“In each subgroup, there is not enough strong evidence that myo-inositol has an effect on fasting glucose.”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [87]
A systematic review and meta-analysis of randomized controlled trials showed that myo-inositol is likely to improve insulin resistance because of a lower HOMA index both in the myo-inositol vs. placebo comparison (WMD −1.11; 95% CI −1.39-0.83; p < 0.00001) and in the myo-inositol vs. metformin or estrogen comparison (WMD −0.33; 95% CI −0.60-0.05; p = 0.02).
“Authors showed that myo-inositol is likely to improve IR because of the lower HOMA index both in the myo-inositol vs. placebo comparison (WMD −1.11; 95% CI −1.39–0.83; p < 0.00001) and in the myo-inositol vs. metformin or estrogen comparison (WMD −0.33; 95% CI −0.60–0.05; p = 0.02).”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [87]
In the myo-inositol vs. placebo subgroup, myo-inositol is likely to improve hyperinsulinemia because of lower fasting insulin (WMD −3.97; 95% CI −5.76, −2.18; p < 0.00001).
“In the myo-inositol vs. placebo subgroup, myo-inositol is likely to improve hyperinsulinemia because of the lower fasting insulin (WMD −3.97; 95% CI −5.76, −2.18; p < 0.00001), while in the myo-inositol vs. metformin or estrogen subgroup, there is not enough strong evidence (WMD −0.99; 95% CI −2.43, 0.45; p = 0.19).”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [87]
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Greff, D., Juhász, A. E., Váncsa, S., Váradi, A., Sipos, Z., Szinte, J., Park, S., Hegyi, P., Nyírády, P., Ács, N., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22601932
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Chaudhary, A., Khemani, M., Makhija, B., & Kaur, K. (2026) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20263432
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- Authors
- Zeng, L., & Yang, K.
- Affiliations
- Hunan University of Traditional Chinese Medicine (CN)
- Corresponding author
- Zeng, Liuting
- Venue
- Endocrine
- Published
- 2017-10-19
- Volume
- 59
- Issue
- 1
- Pages
- 30-38
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2765988286
- Cited by
- 59
- References
- 38
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 15 · 2019: 4 · 2018: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- myo-inositol, polycystic ovary syndrome, insulin resistance, HOMA index, estradiol, total testosterone, PCOS treatment, estrogen deficiency
- MeSH terms
- Estradiol, Female, Humans, Inositol, Metformin, Polycystic Ovary Syndrome, Testosterone, Randomized Controlled Trials as Topic, Treatment Outcome
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