The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
PUFAs: Structures, Metabolism and Functions
Open accessAbstract
Polyunsaturated fatty acids (PUFAs) include two series of fatty acids: omega-6 and omega-3 series. PUFAs have amphiphatic properties: hydrophilic head and hydrophobic tail. Such structure and other properties of unsaturated fatty acids are responsible for exerting the following biological action: maintaining cell-membrane fluidity, inhib- iting inflammatory processes, decreasing secretion of proinflammatory cytokines by monocytes/macrophages, decreasing susceptibility to ventricular rhythm disorders of the heart, improving functions of vascular endothe- lial cells, inhibiting blood platelet aggregation and decreasing triglyceride synthesis in the liver. In an organism, aracidonic acid (ARA) is converted to prostanoids series 2 (PGE2, PGI2, TXA2) and leukotrienes series 4 (LTB4, LTC4, LTD4) which are endowed with pro-inflammatory potential and are able to induce platelet aggregation and vasoconstriction. The metabolism of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) gives prostanoids series 3 (PGE3, PGI3, TXA3) and leukotrienes series 5 (LTB5, LTC5, LTD5); this group of eicosanoids shows anti-inflammatory, antiplatelet and antiarrhythmic properties.
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Cites
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Chemistry and metabolism of lipids in the vertebrate retina
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Mechanisms of action of docosahexaenoic acid in the nervous system
Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919
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Thies, F., Garry, J. M., Yaqoob, P., Rerkasem, K., Williams, J., Shearman, C. P., Gallagher, P. J., Calder, P. C., & Grimble, R. F. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12468-3 · Cited by 739
Omega-3 Fatty Acids: Evidence Basis for Treatment and Future Research in Psychiatry
Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Davis, J. M., Mischoulon, D., Peet, M., Keck, P. E., Marangell, L. B., Richardson, A. J., Lake, J., et al. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1217 · Cited by 709
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Algal-Oil Capsules and Cooked Salmon: Nutritionally Equivalent Sources of Docosahexaenoic Acid
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Cited by
Arachidonic acid: Physiological roles and potential health benefits – A review
Tallima, H., & El Ridi, R. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2017.11.004 · Cited by 671
Effects of Omega-3 Fatty Acids on Immune Cells
Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205028 · Cited by 525
Prostaglandin E 2 as a Regulator of Immunity to Pathogens
Martínez-Colón, G. J., & Moore, B. B. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.008 · Cited by 109
Metadata
- Authors
- Wiktorowska-Owczarek, A., Berezińska, M., & Nowak, J. Z.
- Venue
- Advances in Clinical and Experimental Medicine
- Publisher
- Wroclaw Medical University
- Published
- 2015-09-15
- Volume
- 24
- Issue
- 6
- Pages
- 931-941
- ISSN
- 1899-5276 (ISSN-L)
- OpenAlex
- W2243973902
- Cited by
- 293
- References
- 8
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- gold
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