Effect of statin therapy on oral Candida carriage in hyperlipidemia patients: A pioneer study
Open accessAbstract
BACKGROUND: Hyperlipidemia affects about 25% of the adult population globally. Statins are the most commonly used drugs in the management of hyperlipidemia. Laboratory and retrospective clinical studies have observed the inhibitory effects of statins on the growth of different Candida species. The effect of statin therapy on oral Candida carriage has not yet been investigated. OBJECTIVES: This pioneer controlled study aimed to assess and compare asymptomatic oral Candida carriage in a group of 50 hyperlipidemic patients who were on regular statin therapy (HLS group) and in a control group of 50 subjects, matched in terms of gender, age and dental status, who were hyperlipidemic, but not on statin therapy (HLNS group). MATERIAL AND METHODS: The patients were recruited from the outpatient clinics of 2 university hospitals. The concentrated oral rinse technique was used to isolate oral Candida species in both groups. Candida species were identified using the germ tube test and the VITEK® 2 system. RESULTS: The Candida prevalence and colony count were significantly lower in the HLS group as compared to the HLNS group (n = 20, 40% vs. n = 30, 60%, respectively; p = 0.040). There was no significant difference in the oral Candida prevalence or colony count between different age groups in either the statin or control subjects. CONCLUSIONS: Statin therapy is associated with a reduction in oral Candida carriage in both prevalence and the colony count in hyperlipidemic patients.
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In hyperlipidemic patients, regular statin therapy is associated with significantly lower prevalence and colony counts of oral Candida compared with no statin therapy (40% vs 60%, p = 0.040).
“The prevalence and colony counts of Candida were significantly lower in the HLS group compared with the HLNS group (20 patients, 40% vs. 30 patients, 60%, respectively; p = 0.040).”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [123]
In the clinical investigation of statin use and oral Candida colonization, dosing regimens were not standardized because it was an exploratory study involving patients already under statin treatment.
“Nevertheless, because this was an exploratory study involving patients already under statin treatment, dosing regimens were not standardized.”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [123]
Statin therapy may be associated with a reduction in both the prevalence and burden of oral Candida colonization.
“These findings suggest that statin therapy may be associated with a reduction in both the prevalence and burden of oral Candida colonization.”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [123]
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e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7 · see citing works
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Morifuji, Y., Fukutani, T., Wakamatsu, K., MARUKO, M., Nakase, Y., Hamada, A., Okamoto, K., & Yanamoto, S. (2026) · Research Square · doi:10.21203/rs.3.rs-8441654/v1
- Authors
- Darwazeh, A., Al-Shorman, H., & Mrayan, B.
- Affiliations
- Jordan University of Science and Technology (JO)
- Corresponding author
- Darwazeh, Azmi
- Venue
- Dental and Medical Problems
- Publisher
- Wroclaw Medical University
- Published
- 2022-02-28
- Volume
- 59
- Issue
- 1
- Pages
- 93-97
- ISSN
- 1644-387X (ISSN-L)
- 2300-9020
- OpenAlex
- W4214592267
- Cited by
- 3
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dental and Medical Problems (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greater South Information System
- Funders
- Jordan University of Science and Technology
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- statins, hyperlipidemia, Candida species, oral candidiasis
- MeSH terms
- Adult, Candida, Humans, Hyperlipidemias, Mouth, Retrospective Studies, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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