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Cited by 31Antifungal resistance and susceptibilityCancer, Lipids, and MetabolismHyperglycemia and glycemic control in critically ill and hospitalized patients

Statin therapy and decreased incidence of positive Candida cultures among patients with type 2 diabetes mellitus undergoing gastrointestinal surgery.

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Spanakis, Elias K., Kourkoumpetis, Themistoklis K., Livanis, Grigorios, Peleg, Anton Y., Mylonakis, Eleftherios·2010·Mayo Clinic Proceedings
DOI 10.4065/mcp.2010.0447PMC PMC2996154
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Abstract

Objective To assess whether statin therapy decreases the incidence of cultures positive for Candida species among high-risk hospitalized patients with type 2 diabetes mellitus (DM).Patients and methods We performed a retrospective cohort study analyzing the records of all patients with type 2 DM who were admitted to Massachusetts General Hospital for lower gastrointestinal tract surgery between January 1, 2001, and May 1, 2008. We defined statin exposure as the filling of at least 1 prescription of statins during the 6 months before hospitalization or during the current hospital stay. The primary outcome was a culture positive for Candida species during hospitalization. Clinical information on a wide range of covariates was collected. Logistic regression analysis was used to adjust for possible confounders.Results Of the 1019 patients who were eligible for the study, 493 (48%) were receiving statins. A total of 139 patients (14%) had at least 1 culture positive for Candida species during hospitalization. An adjusted multivariate model based on a backward stepwise elimination procedure showed that statin therapy significantly decreased the incidence of cultures positive for Candida species (odds ratio, 0.60; 95% confidence interval [CI], 0.38-0.96; P=.03) with a statistically significant prolonged time to event compared with no statin therapy (adjusted hazard ratio, 0.62; 95% CI, 0.44-0.88; P=.01). The benefit of statins was more prominent in patients with type 2 DM who had greater comorbidities (Charlson Comorbidity Index ≥2) (adjusted odds ratio, 0.47; 95% CI, 0.27-0.79; P=.01).Conclusion Among patients with type 2 DM who underwent gastrointestinal surgery, use of statins correlated with a decreased incidence of cultures positive for Candida species.

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Pravastatin enhanced survival and led to a decreased fungal burden in C3H/HeN mice infected with C. albicans.

    “other work has demonstrated that pravastatin enhanced survival and led to a decreased fungal burden in C3H/HeN mice infected with C. albicans and the potential benefits of statins in the clinic against Candida have been described [10, 40-42].”

    From Assessment of the in vitro and in vivo activity of atorvastatin against Candida albicans. (2019) · cites this paper as [10]

  • Some studies have described potential benefits for statin use during Candida infection in mice and in a clinical setting.

    “Although some studies have described potential benefits for statin use during a Candida infection both in mice (Tashiro et al., 2012) and in a clinical setting (Forrest et al., 2010; Spanakis et al., 2010; Cuervo et al., 2013)”

    From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Spanakis et al., 2010

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Authors
Spanakis, E. K., Kourkoumpetis, T. K., Livanis, G., Peleg, A. Y., & Mylonakis, E.
Affiliations
  • Harvard University (US)
  • Northeastern University (US)
  • Beth Israel Deaconess Medical Center (US)
Corresponding author
  • Spanakis, Elias K.
  • Mylonakis, Eleftherios
ORCID
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2010-12
Volume
85
Issue
12
Pages
1073-1079
ISSN
0025-6196 (ISSN-L)
DOI
10.4065/mcp.2010.0447
PMC
PMC2996154
OpenAlex
W2072741762
Cited by
31
References
31
Citations by year
2026: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 1
FWCI
1.24
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • Astellas Pharma US
  • Astellas Pharma
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Keywords
statins, Candida, type 2 diabetes, gastrointestinal surgery, candidiasis, antifungal susceptibility, hospitalized patients, Charlson Comorbidity Index, fungal infection prevention
MeSH terms
Aged, Candidiasis, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Logistic Models, Proportional Hazards Models, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lower Gastrointestinal Tract

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