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Cited by 136Antifungal resistance and susceptibilityCancer, Lipids, and MetabolismFungal and yeast genetics research

Growth inhibition of Candida species and Aspergillus fumigatus by statins

Macreadie, Ian G., Johnson, Georgia, Schlosser, Tanja, Macreadie, Peter I.·2006·FEMS Microbiology Letters
DOI 10.1111/j.1574-6968.2006.00370.x
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Abstract

Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy.

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Crossref · 10.1111/j.1574-6968.2006.00370.x

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  • Various statins have been reported to inhibit the growth of Aspergillus, Zygomycete, Cryptococcus, and Candida species including Candida albicans.

    “Various statins have been reported to inhibit the growth of Aspergillus (Macreadie et al., 2006; Yasmin et al., 2012), Zygomycete (Roze and Linz, 1998), Cryptococcus (Chin et al., 1997), and Candida species including Candida albicans (Chin et al., 1997; Song et al., 2003).”

    From Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice (2015) · cites this paper as Macreadie et al., 2006

  • Supplementation with ergosterol or cholesterol reduced the antifungal effect of statins.

    “This assumption is confirmed by the observation that supplementation with ergosterol or cholesterol reduced the antifungal effect of statins [20,25,26] , and that C. albicans transformed from the yeast cell form to the”

    From Statins as antifungal agents (2011) · cites this paper as [25]

  • Supplementation of sterols to the medium reduces the antifungal activity of statins, as in yeasts.

    “Furthermore, supplementation of sterols to the medium reduces the antifungal activity of statins, as in the case of yeasts [25] .”

    From Statins as antifungal agents (2011) · cites this paper as [25]

  • Macreadie et al. found MIC values higher than 40 g/ml for simvastatin and 100 g/ml for atorvastatin against Candida strains.

    “Macreadie et al. 23 found MIC values higher than 40 g/ml for simvastatin and 100 g/ml for atorvastatin against Candida strains.”

    From Synergistic antifungal activity of statin–azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification (2013) · cites this paper as [23]

  • Present results on ergosterol recovery from statin-induced inhibition agreed with previous observations of a sterol dose-dependent mode of action.

    “Concerning ergosterol recovery from statin-induced inhibition, present results were in agreement with previous observations with reference to the sterol dose-dependent mode of action.23”

    From Synergistic antifungal activity of statin–azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification (2013) · cites this paper as [23]

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Authors
Macreadie, I. G., Johnson, G., Schlosser, T., & Macreadie, P. I.
Affiliations
Commonwealth Scientific and Industrial Research Organisation (AU)
ORCID
Venue
FEMS Microbiology Letters
Publisher
Oxford University Press (OUP)
Published
2006-09
Volume
262
Issue
1
Pages
9-13
ISSN
  • 0378-1097 (ISSN-L)
  • 1574-6968
DOI
10.1111/j.1574-6968.2006.00370.x
OpenAlex
W2054780467
Cited by
136
References
12
Citations by year
2026: 4 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 2 · 2013: 10 · 2012: 9
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Locations
  • FEMS Microbiology Letters (publishedVersion)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion)
  • OPUS - Open Publications of UTS Scholars (University of Technology Sydney) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
statins, simvastatin, atorvastatin, Candida, Aspergillus fumigatus, Candida albicans, Candida krusei, antifungal agents, mevalonate pathway, ergosterol, cholesterol, fungal growth inhibition, statin therapy
MeSH terms
Atorvastatin, Antifungal Agents, Aspergillus fumigatus, Candida, Cholesterol, Ergosterol, Growth Inhibitors, Heptanoic Acids, Mevalonic Acid, Pyrroles, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin

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