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The gut microbiota modulates airway inflammation in allergic asthma through the gut-lung axis related immune modulation: A review

Zhang, Meng, Qin, Ziwen, Huang, Chuanjun, Liang, Bin, Zhang, Xiuqing, Sun, Weitao·2024·Biomolecules and Biomedicine
DOI 10.17305/bb.2024.11280PMC PMC11959394
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Abstract

The human gut microbiota is a vast and complex microbial community. According to statistics, the number of bacteria residing in the human intestinal tract is approximately ten times that of total human cells, with over 1000 different species. The interaction between the gut microbiota and various organ tissues plays a crucial role in the pathogenesis of local and systemic diseases, exerting a significant influence on disease progression. The relationship between the gut microbiota and intestinal diseases, along with its connection to the pulmonary immune environment and the development of lung diseases, is commonly referred to as the “gut–lung axis.” The incidence of bronchial asthma is rising globally. With ongoing research on gut microbiota, it is widely believed that intestinal microorganisms and their metabolic products directly or indirectly participate in the occurrence and development of asthma. Based on the gut–lung axis, this review examines recent research suggesting that the intestinal microbiota can influence the occurrence and progression of allergic asthma through the modulation of cytokine immune balance and mucosal integrity. Though the precise immune pathways or microbial species influencing asthma through the gut–lung axis are still under exploration, summarizing the immune modulation through the gut–lung axis in allergic asthma may provide insights for the clinical management of the condition.

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Figure 1. Lung microbial dysbiosis in asthma: The gut–lung axis. The lung microbiota plays a crucial role in maintaining a healthy immune response. Microbes in the oral cavity and upper airways shape the microbial communities in the lower airways and lungs. Environmental factors may contribute to lung dysbiosis, characterized by an increase in bacterial communities in asthma. Lung dysbiosis leads to heightened lung inflammation and immune dysfunction, initiating allergic asthma (illustrated in red). This inflammatory process may promote specific bacterial communities that contribute to further microbial dysbiosis.
Figure 1. Lung microbial dysbiosis in asthma: The gut–lung axis. The lung microbiota plays a crucial role in maintaining a healthy immune response. Microbes in the oral cavity and upper airways shape the microbial communities in the lower airways and lungs. Environmental factors may contribute to lung dysbiosis, characterized by an increase in bacterial communities in asthma. Lung dysbiosis leads to heightened lung inflammation and immune dysfunction, initiating allergic asthma (illustrated in red). This inflammatory process may promote specific bacterial communities that contribute to further microbial dysbiosis.CC BY · PubMed Central

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Metadata

Authors
Zhang, M., Qin, Z., Huang, C., Liang, B., Zhang, X., & Sun, W.
Venue
Biomolecules and Biomedicine
Publisher
Association of Basic Medical Sciences of FBIH
Published
2024-10-26
Volume
25
Issue
4
Pages
727-738
ISSN
  • 2831-090X
  • 2831-0896
DOI
10.17305/bb.2024.11280
PMC
PMC11959394
Cited by
35
References
0
Licence
creativecommons.org/licenses/by/4.0 (unspecified)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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