The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
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“mitochondrial uncoupling, either genetically through the overexpression of the uncoupling protein UCP1 or by administration of the chemical uncoupler 2-4-dinitrophenol can increase lifespan in flies and mice”
From The Hallmarks of Aging (2013) · cites this paper as Fridell et al., 2009
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Cites
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
Mitochondrial function in normal and diabetic β-cells
Maechler, P., & Wollheim, C. B. (2001) · Nature · doi:10.1038/414807a · Cited by 519
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401
Chan, C. B., De Leo, D., Joseph, J. W., McQuaid, T. S., Ha, X. F., Xu, F., Tsushima, R. G., Pennefather, P. S., Salapatek, A. M. F., & Wheeler, M. B. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1302 · Cited by 341
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet
Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3211 · Cited by 220
Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression
Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409189200 · Cited by 206
Flagged first, then by citations
Research works printed but not linked: 28
- Kim, 2001, Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes, Cell, 10, 745
- Brand, 2008, Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion, Biochem J, 40, 199
- Helfand, 2005, Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly, Cell Metab, 1, 145, 10.1016/j.cmet.2005.01.005 · DOI
- Ashcroft, 2006, K(ATP) channels and insulin secretion: a key role in health and disease, Biochem Soc Trans, 3, 243, 10.1042/BST0340243 · DOI
- Lowell, 2005, The mitochondrial uncoupling-protein homologues, Nat Rev Mol Cell Biol, 6, 248, 10.1038/nrm1592 · DOI
- Rulifson, 2004, Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells, Nature, 43, 316
- Nusse, 2002, Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes, Science, 29, 1118
- Leevers, 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands, Proc Natl Acad Sci U S A, 10, 3105
- Park, 2004, Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster, Genetics, 16, 311
- Hafen, 2002, Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila, Curr Biol, 1, 1293
- Gaskell, 1990, The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide, Biochem J, 26, 315
- Schaffer, 1995, Identification and expression of the Drosophila adipokinetic hormone gene, Mol Cell Endocrinol, 10, 133
- Brand, 2008, On the role of uncoupling protein-2 in pancreatic beta cells, Biochim Biophys Acta, 177, 973
- Davis, 2003, Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters, J Neurosci, 2, 64
- Cantley, 1999, The role of phosphoinositide 3-kinase lipid products in cell function, J Biol Chem, 27, 8347
- Edgar, 2002, Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions, Dev Cell, 2, 239, 10.1016/S1534-5807(02)00117-X · DOI
- Tjian, 2003, Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway, Genes Dev, 1, 2006
- Helfand, 2007, Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling, Proc Natl Acad Sci U S A, 10, 13355
- Antebi, 2003, The endocrine regulation of aging by insulin-like signals, Science, 29, 1346
- Nichols, 2005, Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection, Diabetes, 5, 3065
- Rorsman, 2004, Molecular defects in insulin secretion in type-2 diabetes, Rev Endocr Metab Disord, 5, 135, 10.1023/B:REMD.0000021435.87776.a7 · DOI
- Bodmer, 2006, The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman, Proc Natl Acad Sci U S A, 10, 11999
- Karschin, 2002, Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function, J Biol Chem, 27, 25554
- Harshman, 2005, Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary, J Insect Physiol, 5, 455
- Tatar, 2004, Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body, Nature, 42, 562
- Beutler, 2007, ATP-sensitive potassium channels mediate survival during infection in mammals and insects, Nat Genet, 3, 1453
- Wu, 2004, A modified minimal hemolymph-like solution, HL3.1, for physiological recordings at the neuromuscular junctions of normal and mutant Drosophila larvae, J Neurogenet, 1, 377
- Helfand, 2006, Involvement of Drosophila uncoupling protein 5 in metabolism and aging, Genetics, 17, 1699
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Eat to reproduce: a key role for the insulin signaling pathway in adult insects
Badisco, L., Van Wielendaele, P., & Vanden Broeck, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00202 · Cited by 173
Kapan, N., Lushchak, O. V., Luo, J., & Nässel, D. R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1097-z · Cited by 169
Metadata
- Authors
- Fridell, Y.-W. C., Hoh, M., Kréneisz, O., Hosier, S., Chang, C., Scantling, D., Mulkey, D. K., & Helfand, S. L.
- Affiliations
- Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA
- Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2009-07-21
- Volume
- 1
- Issue
- 8
- Pages
- 699-713
- ISSN
- 1945-4589
- PMC
- PMC2830081
- Cited by
- 63
- References
- 6
- Language
- en
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