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Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

Fridell, Yih-Woei C., Hoh, Melissa, Kréneisz, Orsolya, Hosier, Suzanne, Chang, Chengyi, Scantling, Dane, Mulkey, Daniel K., Helfand, Stephen L.·2009·Aging

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Crossref · 10.18632/aging.100067

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  1. Kim, 2001, Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes, Cell, 10, 745
  2. Brand, 2008, Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion, Biochem J, 40, 199
  3. Helfand, 2005, Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly, Cell Metab, 1, 145, 10.1016/j.cmet.2005.01.005 · DOI
  4. Ashcroft, 2006, K(ATP) channels and insulin secretion: a key role in health and disease, Biochem Soc Trans, 3, 243, 10.1042/BST0340243 · DOI
  5. Lowell, 2005, The mitochondrial uncoupling-protein homologues, Nat Rev Mol Cell Biol, 6, 248, 10.1038/nrm1592 · DOI
  6. Rulifson, 2004, Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells, Nature, 43, 316
  7. Nusse, 2002, Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes, Science, 29, 1118
  8. Leevers, 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands, Proc Natl Acad Sci U S A, 10, 3105
  9. Park, 2004, Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster, Genetics, 16, 311
  10. Hafen, 2002, Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila, Curr Biol, 1, 1293
  11. Gaskell, 1990, The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide, Biochem J, 26, 315
  12. Schaffer, 1995, Identification and expression of the Drosophila adipokinetic hormone gene, Mol Cell Endocrinol, 10, 133
  13. Brand, 2008, On the role of uncoupling protein-2 in pancreatic beta cells, Biochim Biophys Acta, 177, 973
  14. Davis, 2003, Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters, J Neurosci, 2, 64
  15. Cantley, 1999, The role of phosphoinositide 3-kinase lipid products in cell function, J Biol Chem, 27, 8347
  16. Edgar, 2002, Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions, Dev Cell, 2, 239, 10.1016/S1534-5807(02)00117-X · DOI
  17. Tjian, 2003, Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway, Genes Dev, 1, 2006
  18. Helfand, 2007, Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling, Proc Natl Acad Sci U S A, 10, 13355
  19. Antebi, 2003, The endocrine regulation of aging by insulin-like signals, Science, 29, 1346
  20. Nichols, 2005, Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection, Diabetes, 5, 3065
  21. Rorsman, 2004, Molecular defects in insulin secretion in type-2 diabetes, Rev Endocr Metab Disord, 5, 135, 10.1023/B:REMD.0000021435.87776.a7 · DOI
  22. Bodmer, 2006, The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman, Proc Natl Acad Sci U S A, 10, 11999
  23. Karschin, 2002, Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function, J Biol Chem, 27, 25554
  24. Harshman, 2005, Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary, J Insect Physiol, 5, 455
  25. Tatar, 2004, Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body, Nature, 42, 562
  26. Beutler, 2007, ATP-sensitive potassium channels mediate survival during infection in mammals and insects, Nat Genet, 3, 1453
  27. Wu, 2004, A modified minimal hemolymph-like solution, HL3.1, for physiological recordings at the neuromuscular junctions of normal and mutant Drosophila larvae, J Neurogenet, 1, 377
  28. Helfand, 2006, Involvement of Drosophila uncoupling protein 5 in metabolism and aging, Genetics, 17, 1699

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Metadata

Authors
Fridell, Y.-W. C., Hoh, M., Kréneisz, O., Hosier, S., Chang, C., Scantling, D., Mulkey, D. K., & Helfand, S. L.
Affiliations
  • Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA
  • Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA
Venue
Aging
Published
2009-07-21
Volume
1
Issue
8
Pages
699-713
ISSN
1945-4589
Cited by
63
References
6
Language
en

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