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Cited by 250

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

Open access
Demaria, Marco, Giorgi, Carlotta, Lebiedzinska, Magdalena, Esposito, Giovanna, D'Angeli, Luca, Bartoli, Antonietta, Gough, Daniel J., Turkson, James, Levy, David E., Watson, Christine J., Wieckowski, Mariusz R., Provero, Paolo, Pinton, Paolo, Poli, Valeria·2010·Aging
DOI 10.18632/aging.100232
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Abstract

The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of tumours that often become addicted to its activity, but no unifying view of a core function determining this widespread STAT3-dependence has yet emerged. We show here that constitutively active STAT3 acts as a master regulator of cell metabolism, inducing aerobic glycolysis and down-regulating mitochondrial activity both in primary fibroblasts and in STAT3-dependent tumour cell lines. As a result, cells are protected from apoptosis and senescence while becoming highly sensitive to glucose deprivation. We show that enhanced glycolysis is dependent on HIF-1α up-regulation, while reduced mitochondrial activity is HIF-1α-independent and likely caused by STAT3-mediated down-regulation of mitochondrial proteins. The induction of aerobic glycolysis is an important component of STAT3 pro-oncogenic activities, since inhibition of STAT3 tyrosine phosphorylation in the tumour cell lines down-regulates glycolysis prior to leading to growth arrest and cell death, both in vitro and in vivo. We propose that this novel, central metabolic role is at the core of the addiction for STAT3 shown by so many biologically different tumours.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 42

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Cited by

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Metadata

Authors
Demaria, M., Giorgi, C., Lebiedzinska, M., Esposito, G., D'Angeli, L., Bartoli, A., Gough, D. J., Turkson, J., Levy, D. E., Watson, C. J., Wieckowski, M. R., Provero, P., Pinton, P., & Poli, V.
Venue
Aging
Publisher
Impact Journals, LLC
Published
2010-11-15
Volume
2
Issue
11
Pages
823-842
ISSN
1945-4589 (ISSN-L)
DOI
10.18632/aging.100232
OpenAlex
W181556572
Cited by
250
References
9
FWCI
4.34
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. https://app.cochat.ai/papers/10.18632/aging.100232
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Demaria, M., Giorgi, C., Lebiedzinska, M., Esposito, G., D'Angeli, L., Bartoli, A., Gough, D. J., Turkson, J., Levy, D. E., Watson, C. J., Wieckowski, M. R., Provero, P., Pinton, P., & Poli, V. (2010). A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging. https://doi.org/10.18632/aging.100232

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