Ultraviolet A Irradiation Induces Senescence in Human Dermal Fibroblasts by Down-Regulating DNMT1 via ZEB1
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experiments confirmed that UVA irradiation reduced p53 promoter methylation, and DNMT1 up-regulation could reverse this effect. Collectively, down-regulation of ZEB1 caused by UVA induced ROS could transcriptionally inhibit DNMT1, leading to low methylation level of senescence related proteins p53 and increase its expression, eventually result in cellar senescence.
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Downregulation of ZEB2 promotes cell senescence in hepatic stellate cells and dermal fibroblasts, limiting fibrosis.
“In support of this concept, there is evidence that the downregulation of the Zn-finger protein ZEB2 significantly promotes cell senescence in hepatic stellate cells and dermal fibroblasts, limiting the development of fibrosis [435,436].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [436]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Yi, Y., Xie, H., Xiao, X., Wang, B., Du, R., Liu, Y., Li, Z., Wang, J., Sun, L., Deng, Z., & Li, J.
- Affiliations
- Central South University (CN)
- Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China
- Corresponding author
- Deng, Zhili
- Li, Ji
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2018-02-16
- Volume
- 10
- Issue
- 2
- Pages
- 212-228
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC5842848
- OpenAlex
- W2792363747
- Cited by
- 39
- References
- 43
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 2
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Xiangya Hospital, Central South University
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- UVA irradiation, cellular senescence, dermal fibroblasts, DNMT1, ZEB1, DNA methylation, reactive oxygen species, transcriptional repression
- MeSH terms
- Zinc Finger E-box-Binding Homeobox 1, Fibroblasts, Humans, Repressor Proteins, Skin Physiological Phenomena, Ultraviolet Rays, Down-Regulation, Skin Aging, Up-Regulation, Tumor Suppressor Protein p53, Cellular Senescence, Reactive Oxygen Species
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