Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms
Open accessAbstract
BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed published in English language in 2004-2017, using appropriate key words, including "aging", "children", "HIV", "AIDS", "immunosenescence", "pathogenesis", "clinical conditions". RESULTS: cells. Other reported features of premature aging include cellular replicative senescence, linked to an accelerated telomeres shortening. Finally, acceleration of age-associated methylation pattern and other epigenetic modifications have been described in HIV-infected children. All these features may favor the clinical manifestations related to premature aging. Lipid and bone metabolism, cancers, cardiovascular, renal, and neurological systems should be carefully monitored, particularly in children with detectable viremia and/or with CD4/CD8 ratio inversion. CONCLUSION: Aging processes in children with HIV infection impact their quality and length of life. Further studies regarding the mechanisms involved in premature aging are needed to search for potential targets of treatment.
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HIV-infected individuals, even children and young adults, display an immunosenescent phenotype.
“HIV‐infected individuals, even in children and young adults, display an immunosenescent phenotype (Chiappini et al, 2018).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Chiappini et al, 2018
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Rakhmanina, N. Y. (2014) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.1000311 · Cited by 12 · see citing works
Endocrinopathies in Children Infected with Human Immunodeficiency Virus
Loomba‐Albrecht, L. A., Bregman, T., & Chantry, C. J. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.06.001 · Cited by 12 · see citing works
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Treatment of HIV associated cerebral vasculopathy
Connor, M. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.169490 · Cited by 10 · see citing works
T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults
Mattingly, A. S., Unsal, A. B., Purdy, J., et al. (2016) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001354 · Cited by 10 · see citing works
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Strategies for the Prevention of Mother to Child Transmission in Western Countries
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Self-citation
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The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
- Authors
- Chiappini, E., Bianconi, M., Dalzini, A., Petrara, M. R., Galli, L., Giaquinto, C., & De Rossi, A.
- Affiliations
- Meyer Children's Hospital (IT)
- University of Padua (IT)
- Section of Oncology and Immunology, Department of Surgery, Oncology and Gastroenterology, Unit of viral Oncology and AIDS Reference Center, University of Padova, Padova, Italy
- Corresponding author
- Chiappini, Elena
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2018-11-11
- Volume
- 10
- Issue
- 11
- Pages
- 3610-3625
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC6286860
- OpenAlex
- W2900098406
- Cited by
- 46
- References
- 101
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 4
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Funders
- Università degli Studi di Padova (BIRD2017, IG-19112)
- Associazione Italiana per la Ricerca sul Cancro (IG-19112, IG-14258, 19112, 14258)
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- premature aging, perinatal HIV infection, HIV-infected children, immunosenescence, telomere shortening, epigenetic aging, viremia, cardiovascular disease, kidney disease, neurological disorders, cancer risk, lipid metabolism, bone metabolism
- MeSH terms
- Immunosenescence, Child, Humans, Inflammation, HIV Infections, Aging, Premature
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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