Telomeres and aging

Shay, Jerry W

doi:10.1016/j.ceb.2017.12.001

Cited by 174Telomeres, Telomerase, and SenescenceNuclear Structure and FunctionGenomics and Chromatin Dynamics

Telomeres and aging

Shay, Jerry W·2018·Current Opinion in Cell Biology

DOI 10.1016/j.ceb.2017.12.001

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Abstract

Telomeres (the TTAGGG repetitive DNA at the ends of linear chromosomes) are part of the 3D spatial organization of the nuclear genome. Long-range 3D chromatin interactions also establish specific patterns of regulated gene expression. An emerging area of interest is the role of telomere 3D looping with interstitial telomeric sequences (ITS) through interactions with telomere shelterin proteins. Telomeres form interstitial telomere loops (ITL) that interact with ITS and modify gene expression at distal genomic regions. Human laminopathies and telomeropathies often correlate with short telomeres. Since telomeres progressively shorten with increased turnover and chronological age in dividing somatic cells, ITLs may also change and have functional roles in normal and pathophysiological processes. Overall, telomeres help stabilize the nuclear genome with high fidelity throughout early adult life but diminish in post-reproductive age-associated pathology.

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A telomere is shortened with cell division and is closely associated with cell division and senescence.
“A telomere is shortened with cell division and is associated closely with cell division and senescence [38,39].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [39]
Telomeres are DNA-protein complexes at the end tips of eukaryotic linear chromosomes and are important for maintaining chromosomal integrity and controlling the cell cycle.
“Telomeres are a small piece of DNA-protein complex at the end tips of eukaryotic linear chromosomes, which are important components in maintaining the chromosomal integrity and controlling the cell cycle.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [39]
Reactive oxygen generated by UV radiation induces telomere mutation, cell death, or senescence.
“The reactive oxygen generated by UV radiation induces telomere mutation, cell death, or senescence.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [39]

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Authors: Shay, J. W.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Shay, Jerry W
ORCID: Shay, Jerry W
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2018-06
Volume: 52
Pages: 1-7
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/j.ceb.2017.12.001
OpenAlex: W2771365678
Cited by: 174
References: 39
Citations by year: 2026: 8 · 2025: 13 · 2024: 19 · 2023: 21 · 2022: 33 · 2021: 21 · 2020: 34 · 2019: 20 · 2018: 5
FWCI: 1.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AG01228, C06 RR30414)
Harold Simmons National Cancer Institute Designated Comprehensive Cancer Center Support Grant (CA142543)
Southland Financial Corporation Distinguished Chair in Geriatric Research
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: telomeres, aging, interstitial telomeric sequences, 3D genome organization, laminopathies, telomeropathies, telomere shortening, gene expression regulation
MeSH terms: Aging, Humans, Telomere

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