APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly
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status with age may be useful in assessing possible mechanisms of disease development in AD.
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Even cognitively normal elderly APOE4 carriers exhibit an accelerated decline in white matter integrity.
“Even cognitively normal elderly APOE4 carriers also exhibit an accelerated decline in white matter integrity. 12”
From Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes (2025) · cites this paper as [12]
The Abstract and Discussion report an accelerated age-related reduction in white matter integrity among APOE ε4 carriers compared with noncarriers. However, the Methods define the participants as non-demented, not necessarily cognitively normal, and the Results include participants with mild cognitive impairment. The claim therefore overstates the population studied. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAPOE4 compromises the integrity of white matter, further disrupting brain connectivity and function.
“Beyond its effects on gray matter, APOE4 also compromises the integrity of white matter, further disrupting brain connectivity and function. 10 , 11 , 12”
From Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes (2025) · cites this paper as [12]
The Abstract reports faster age-related loss of white-matter integrity in APOE ε4 carriers, and the Results report associations between white-matter integrity and cognitive performance in older carriers. The paper does not establish that this damage disrupts brain connectivity or causes impaired function; the Discussion presents a link to cognitive deficits as a possibility. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPrevious studies have not combined MRI and histological investigation within the same subjects.
“Notably, previous studies have not combined MRI and histological investigation within the same subjects. 12 , 22 , 26 , 27”
From Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes (2025) · cites this paper as [12]
The Materials and Methods sections on MRI data acquisition and participants describe MRI scans and blood samples for genotyping, but do not discuss histological investigation. Searches for histology combined with MRI in the same subjects found no passage assessing whether previous studies had done so. (LLM, conf=0.74)
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Cites
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Kraus, M. F., Susmaras, T. M., Caughlin, B., Walker, C. J., Sweeney, J. A., & Little, D. M. (2007) · Brain · doi:10.1093/brain/awm216 · Cited by 994 · see citing works
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · cited 1× · see citing works
“Comparing with ε4 allele noncarriers, individuals carrying one copy of ε4 allele had 2- to 3-fold, individuals carrying two copies of ε4 allele had about 12-fold AD risk [2].”
BackgroundDementia and Alzheimer Disease Incidence: A Prospective Cohort Study
Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., van Belle, G., Jolley, L., & Larson, E. B. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1737 · Cited by 806 · see citing works
Life-Span Changes of the Human Brain White Matter: Diffusion Tensor Imaging (DTI) and Volumetry
Westlye, L. T., Walhovd, K. B., Dale, A. M., Bjornerud, A., Due-Tonnessen, P., Engvig, A., Grydeland, H., Tamnes, C. K., Ostby, Y., & Fjell, A. M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp280 · Cited by 765 · see citing works
Langner, R., & Eickhoff, S. B. (2013) · Psychological Bulletin · doi:10.1037/a0030694 · Cited by 746 · see citing works
Douaud, G., Jbabdi, S., Behrens, T. E. J., Menke, R. A., Gass, A., Monsch, A. U., Rao, A., Whitcher, B., Kindlmann, G., Matthews, P. M., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.008 · Cited by 514 · see citing works
Rose, S. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.4.528 · Cited by 465 · see citing works
White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease
Bartzokis, G., Cummings, J. L., Sultzer, D. L., Henderson, V. W., Nuechterlein, K. H., & Mintz, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.393 · Cited by 415 · see citing works
van Ewijk, H., Heslenfeld, D. J., Zwiers, M. P., Buitelaar, J. K., & Oosterlaan, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.01.003 · Cited by 377 · see citing works
Bartzokis, G., Sultzer, D., Lu, P. H., Nuechterlein, K. H., Mintz, J., & Cummings, J. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.005 · Cited by 363 · see citing works
Belleville, S., Fouquet, C., Hudon, C., Zomahoun, H. T. V., & Croteau, J. (2017) · Neuropsychology Review · doi:10.1007/s11065-017-9361-5 · Cited by 308 · see citing works
Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 306 · see citing works
Nathan, B. P., Chang, K.-C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19791 · Cited by 276 · see citing works
Tesseur, I. C., Dorpe, J. V., Spittaels, K., den Haute, C. V., Moechars, D., & LEUVEN, F. V. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64963-2 · Cited by 239 · see citing works
Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Jiang, T., Yu, J., Tian, Y., & Tan, L. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990155 · Cited by 224 · see citing works
Stahl, R., Dietrich, O., Teipel, S. J., Hampel, H. J., Reiser, M. F., & Schoenberg, S. O. (2007) · Radiology · doi:10.1148/radiol.2432051714 · Cited by 215 · see citing works
The APOE ɛ4 allele modulates brain white matter integrity in healthy adults
Heise, V, Filippini, N., Ebmeier, K. P., & Mackay, C. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.90 · Cited by 152 · see citing works
Assessment of white matter tract damage in mild cognitive impairment and Alzheimer's disease
Pievani, M., Agosta, F., Pagani, E., Canu, E., Sala, S., Absinta, M., Geroldi, C., Ganzola, R., Frisoni, G. B., & Filippi, M. (2010) · Human Brain Mapping · doi:10.1002/hbm.20978 · Cited by 146 · see citing works
Strategic white matter tracts for processing speed deficits in age-related small vessel disease
Duering, M., Gesierich, B., Seiler, S., Pirpamer, L., Gonik, M., Hofer, E., Jouvent, E., Duchesnay, E., Chabriat, H., Ropele, S., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000475 · Cited by 143 · see citing works
APOE genotype and stress response - a mini review
Dose, J., Huebbe, P., Nebel, A., & Rimbach, G. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0288-2 · Cited by 137 · see citing works
Rodriguez, G. A., Burns, M. P., Weeber, E. J., & Rebeck, G. W. (2013) · Learning & Memory · doi:10.1101/lm.030031.112 · Cited by 134 · see citing works
Apolipoprotein E Genotype and Age-Related Myelin Breakdown in Healthy Individuals
Bartzokis, G., Lu, P. H., Geschwind, D. H., Edwards, N. J., Mintz, J., & Cummings, J. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.63 · Cited by 128 · see citing works
Gold, B. T., Powell, D. K., Andersen, A. H., & Smith, C. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.036 · Cited by 112 · see citing works
Attentional networks and cingulum bundle in chronic schizophrenia☆
Nestor, P. G., Kubicki, M. R., Spencer, K., Niznikiewicz, M. A., McCarley, R. W., & Shenton, M. E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.10.005 · Cited by 112 · see citing works
Bartzokis, G., Lu, P. H., Geschwind, D. H., Tingus, K., Huang, D., Mendez, M. F., Edwards, N., & Mintz, J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.024 · Cited by 109 · see citing works
APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging
Bookheimer, S. Y., & Burggren, A. C. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153625 · Cited by 104 · see citing works
Li, X., Ma, C., Zhang, J., Liang, Y., Chen, Y., Chen, K., Wang, J., Zhang, Z., & Wang, Y. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12552 · Cited by 102 · see citing works
Self-citationFinkel, D., Pedersen, N. L., Plomin, R. J., & McClearn, G. E. (1998) · Developmental Psychology · doi:10.1037//0012-1649.34.6.1400 · Cited by 94 · see citing works
Nutrition and prevention of Alzheimer’s dementia
Swaminathan, A., & Jicha, G. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00282 · Cited by 93 · see citing works
Superior longitudinal fasciculus and language functioning in healthy aging
Madhavan, K. M., McQueeny, T. M., Howe, S. R., Shear, P. K., & Szaflarski, J. P. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.012 · Cited by 90 · see citing works
Age-related differences in white matter integrity and cognitive function are related to APOE status
Ryan, L., Walther, K., Bendlin, B. B., Lue, L., Walker, D. G., & Glisky, E. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.052 · Cited by 88 · see citing works
Effects of APOE on cognitive aging in community-dwelling older adults.
Reas, E. T., Laughlin, G. A., Bergstrom, J., Kritz‐Silverstein, D. C., Barrett-Connor, E. L., & McEvoy, L. K. (2019) · Neuropsychology · doi:10.1037/neu0000501 · Cited by 82 · see citing works
Region-specific changes of cerebral white matter during normal aging: A diffusion-tensor analysis
Yoon, B., Shim, Y., Lee, K., Shon, Y., & Yang, D. (2007) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2007.07.004 · Cited by 75 · see citing works
Distinctive alterations of the cingulum bundle during aging and Alzheimer’s disease
Catheline, G., Periot, O., Amirault, M., Braun, M., Dartigues, J.-F., Auriacombe, S., & Allard, M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.012 · Cited by 70 · see citing works
Apolipoprotein E genotype, dementia, and mortality in the oldest old: The 90+ Study
Corrada, M. M., Paganini‐Hill, A., Berlau, D. J., & Kawas, C. H. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.12.004 · Cited by 69 · see citing works
Schermuly, I., Fellgiebel, A., Wagner, S., Yakushev, I., Stoeter, P., Schmitt, R., Knickenberg, R. J., Bleichner, F., & Beutel, M. E. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.05.001 · Cited by 67 · see citing works
Chen, Y., Chen, K., Zhang, J., Li, X., Shu, N., Wang, J., Zhang, Z., & Reiman, E. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.302 · Cited by 67 · see citing works
Self-citationLanguage, aging, and cognition
Rizio, A. A., & Diaz, M. T. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000597 · Cited by 64 · see citing works
Christensen, H. M., Batterham, P. J., Mackinnon, A. J., Jorm, A. F., Mack, H. A., Mather, K. A., Anstey, K. J., Sachdev, P. S., & Easteal, S. (2008) · BMC Geriatrics · doi:10.1186/1471-2318-8-14 · Cited by 64 · see citing works
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
Study, F. T. A., Operto, G., Cacciaglia, R., Grau‐Rivera, O., Falcón, C., Brugulat‐Serrat, A., Ródenas, P., Ramos, R., Morán, S., Esteller, M., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0375-x · Cited by 59 · see citing works
A meta-analysis of heritability of cognitive aging: minding the “missing heritability” gap
Reynolds, C., & Finkel, D. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9280-2 · Cited by 59 · see citing works
Tucker–Drob, E. M., Reynolds, C. A., Finkel, D., & Pedersen, N. L. (2013) · Developmental Psychology · doi:10.1037/a0032468 · Cited by 57 · see citing works
APOE Genotype Modulates Proton Magnetic Resonance Spectroscopy Metabolites in the Aging Brain
Gomar, J. J., Gordon, M. L., Dickinson, D., Kingsley, P. B., Uluğ, A. M., Keehlisen, L., Huet, S., Buthorn, J. J., Koppel, J. L., Christen, E., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.022 · Cited by 45 · see citing works
Ten-year longitudinal trajectories of older adults’ basic and everyday cognitive abilities.
Yam, A., Gross, A. L., Prindle, J., & Marsiske, M. (2014) · Neuropsychology · doi:10.1037/neu0000096 · Cited by 41 · see citing works
Operto, G., Molinuevo, J. L., Cacciaglia, R., Falcon, C., Brugulat-Serrat, A., Suárez-Calvet, M., Grau-Rivera, O., Bargalló, N., Morán, S., Esteller, M., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101983 · Cited by 40 · see citing works
Perneczky, R. (2003) · Aktuelle Neurologie · doi:10.1055/s-2003-38269 · Cited by 34 · see citing works
Myelin-Associated Glycoprotein Gene and Brain Morphometry in Schizophrenia
Felsky, D., Voineskos, A. N., Lerch, J. P., Nazeri, A., Shaikh, S. A., Rajji, T. K., Mulsant, B. H., & Kennedy, J. L. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00040 · Cited by 33 · see citing works
Prasad, K. M. R., Upton, C. H., Schirda, C., Nimgaonkar, V. L., & Keshavan, M. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.045 · Cited by 28 · see citing works
Possible Association of APOE Genotype with Working Memory in Young Adults
Sinclair, L. I., Button, K. S., Munafo, M. R., Day, I. N. M., & Lewis, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135894 · Cited by 26 · see citing works
Sali, D., Verganelakis, D. A., Gotsis, E. D., Toulas, P., Papatriantafillou, J., Karageorgiou, C. E., Thomaides, T., Kapsalaki, E. Z., Hadjigeorgiou, G. M., & Papadimitriou, A. (2013) · Acta Neurologica Belgica · doi:10.1007/s13760-013-0197-3 · Cited by 20 · see citing works
The effect of an APOE polymorphism on cognitive function depends on age
Shin, M., Kweon, S., Choi, J., Lee, Y. H., Nam, H., Park, K.-S., Kim, H. N., Song, H., Kim, B. C., Choi, S., et al. (2013) · Journal of Neurology · doi:10.1007/s00415-013-7157-y · Cited by 17 · see citing works
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- Authors
- Sun, J., Zhu, Z., Chen, K., Wei, D., Li, X., Li, H., Zhang, J., Chen, X., Chen, Y., & Zhang, Z.
- Affiliations
- Affiliated Hospital of Qingdao University (CN)
- Fujian Medical University (CN)
- Banner Alzheimer’s Institute (US)
- Beijing Normal University (CN)
- BABRI Centre, Beijing Normal University, Beijing, China
- Corresponding author
- Chen, Xiaochun
- Chen, Yaojing
- Zhang, Zhanjun
- ORCID
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-06-22
- Volume
- 12
- Issue
- 12
- Pages
- 12019-12031
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC7343443
- OpenAlex
- W3038009713
- Cited by
- 16
- References
- 52
- Citations by year
- 2026: 3 · 2025: 8 · 2023: 4 · 2021: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81625025, 31700997, 81820108034, 2018YFC1315200, 81430100)
- National Science Fund for Distinguished Young Scholars (81430100, 2018YFC1315200, 81625025, 81820108034)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- APOE ε4, age-related cognitive decline, white matter injury, Alzheimer's disease, non-demented elderly, genetic risk factors
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Alleles, Alzheimer Disease, Apolipoproteins E, Female, Heterozygote, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Genotyping Techniques, Cognitive Dysfunction, White Matter
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