Association between cingulum bundle structure and cognitive performance: an observational study in major depression

Schermuly, I.; Fellgiebel, A.; Wagner, S.; Yakushev, I.; Stoeter, P.; Schmitt, R.; Knickenberg, R.J.; Bleichner, F.; Beutel, M.E.

doi:10.1016/j.eurpsy.2010.05.001

Cited by 67Advanced Neuroimaging Techniques and ApplicationsTreatment of Major DepressionNeural and Behavioral Psychology Studies

Association between cingulum bundle structure and cognitive performance: an observational study in major depression

Schermuly, I., Fellgiebel, A., Wagner, S., Yakushev, I., Stoeter, P., Schmitt, R., Knickenberg, R.J., Bleichner, F. +1 more·2010·European Psychiatry

DOI 10.1016/j.eurpsy.2010.05.001

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Abstract

Background Major depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression. Methods Region-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression. Results FA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory. Conclusions Brain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression.

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Correlations between executive functions and cingulum white matter properties have been reported in depression, bipolar disorder, and schizophrenia.
“This overall pattern is continued in clinical brain imaging studies as correlations between executive functions and cingulum white matter properties have been reported in depression (with DTI in Schermuly et al., 2010), in bipolar disorder (with DTI in Poletti et al., 2015; with Positron Emission Tomography in Li et al., 2012), and schizophrenia (with DTI in Kubicki et al., 2009; Takei et al., 200”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Schermuly et al., 2010

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Authors: Schermuly, I., Fellgiebel, A., Wagner, S., Yakushev, I., Stoeter, P., Schmitt, R., Knickenberg, R. J., Bleichner, F., & Beutel, M. E.
Affiliations: University Medical Center of the Johannes Gutenberg University Mainz (DE)
Johannes Gutenberg University Mainz (DE)
Rhön-Klinikum (DE)
Corresponding author: Schermuly, I.
ORCID: Fellgiebel, A.
Wagner, S.
Yakushev, I.
Stoeter, P.
Knickenberg, R.J.
Beutel, M.E.
Venue: European Psychiatry
Publisher: Cambridge University Press (CUP)
Published: 2010-10
Volume: 25
Issue: 6
Pages: 355-360
ISSN: 0924-9338 (ISSN-L)
1778-3585
DOI: 10.1016/j.eurpsy.2010.05.001
OpenAlex: W2139883253
Cited by: 67
References: 37
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 6 · 2012: 6
FWCI: 4.42
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 3485 d)
Locations: European Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: major depressive disorder, cingulum, fractional anisotropy, mean diffusivity, executive function, divided attention, cognitive impairment, white matter microstructure, diffusion tensor imaging
MeSH terms: Attention, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Functional Laterality, Male, Memory, Middle Aged, Neuropsychological Tests, Anisotropy, Observation, Diffusion Tensor Imaging

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Association between cingulum bundle structure and cognitive performance: an observational study in major depression

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