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Cited by 470

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis

Open access
Fang, Xiaoyu, Li, Shen, Yu, Hao, Wang, Penghao, Zhang, Yao, Chen, Zheng, Li, Yang, Cheng, Liqing, Li, Wenbin, Jia, Hong, Ma, Xiangyu·2020·Aging

Abstract

A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis. We found that the males had significantly higher disease severity (RR: 1.20, 95% CI: 1.13-1.27, P <0.001) and more prognostic endpoints. Older age was found to be significantly associated with the disease severity and six prognostic endpoints. Chronic kidney disease contributed mostly for death (RR: 7.10, 95% CI: 3.14-16.02), chronic obstructive pulmonary disease (COPD) for disease severity (RR: 4.20, 95% CI: 2.82-6.25), admission to intensive care unit (ICU) (RR: 5.61, 95% CI: 2.68-11.76), the composite endpoint (RR: 8.52, 95% CI: 4.36-16.65,), invasive ventilation (RR: 6.53, 95% CI: 2.70-15.84), and disease progression (RR: 7.48, 95% CI: 1.60-35.05), cerebrovascular disease for acute respiratory distress syndrome (ARDS) (RR: 3.15, 95% CI: 1.23-8.04), coronary heart disease for cardiac abnormality (RR: 5.37, 95% CI: 1.74-16.54). Our study highlighted that the male gender, older age and comorbidities owned strong epidemiological evidence of associations with the severity and prognosis of COVID-19.

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Metadata

Authors
Fang, X., Li, S., Yu, H., Wang, P., Zhang, Y., Chen, Z., Li, Y., Cheng, L., Li, W., Jia, H., & Ma, X.
Venue
Aging
Published
2020-07-13
Volume
12
Issue
13
Pages
12493-12503
ISSN
1945-4589 (ISSN-L)
OpenAlex
W3043794926
Cited by
470
References
34
FWCI
5.40
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis. https://app.cochat.ai/papers/10.18632/aging.103579
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Fang, X., Li, S., Yu, H., Wang, P., Zhang, Y., Chen, Z., Li, Y., Cheng, L., Li, W., Jia, H., & Ma, X. (2020). Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis. Aging. https://doi.org/10.18632/aging.103579

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