Cited by 26Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentAdvanced Proteomics Techniques and Applications

Emerging proteomics biomarkers and prostate cancer burden in Africa

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Adeola, Henry A., Blackburn, Jonathan M., Rebbeck, Timothy R., Zerbini, Luiz F.·2017·Oncotarget

Abstract

// Henry A. Adeola 1,2 , Jonathan M. Blackburn 2,3 ,Timothy R. Rebbeck 4 and Luiz F. Zerbini 1,2 1 International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa 2 Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa 3 Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa 4 Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute, Boston, Massachusetts, USA Correspondence to: Luiz F. Zerbini, email: // Keywords : proteomics, biomarker, prostate cancer, Africa, mass spectrometer Received : November 23, 2016 Accepted : February 27, 2017 Published : March 25, 2017 Abstract Various biomarkers have emerged via high throughput omics-based approaches for use in diagnosis, treatment, and monitoring of prostate cancer. Many of these have yet to be demonstrated as having value in routine clinical practice. Moreover, there is a dearth of information on validation of these emerging prostate biomarkers within African cohorts, despite the huge burden and aggressiveness of prostate cancer in men of African descent. This review focusses of the global landmark achievements in prostate cancer proteomics biomarker discovery and the potential for clinical implementation of these biomarkers in Africa. Biomarker validation processes at the preclinical, translational and clinical research level are discussed here, as are the challenges and prospects for the evaluation and use of novel proteomic prostate cancer biomarkers.

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  • Only a few findings from biomedical research find their way into clinical application.

    “Despite these burgeoning body of relevant scientific knowledge emanating from biomedical research, only a few find their way into clinical application [9-11]; clinical problems are hardly translated into research projects [12].”

    From The dentist-scientist career pathway in Africa: opportunities and obstacles (2018) · cites this paper as [10]

    The Abstract (page unavailable) says that many emerging prostate-cancer biomarkers have not yet demonstrated value in routine clinical practice, and the Current Approaches section says they are poorly validated. This supports the point about limited clinical translation of biomarkers, but the source does not establish the broader claim about biomedical research findings generally. (LLM, conf=0.85)

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Research works printed but not linked: 1

  1. [7]Sitas F Parkin M Chirenje Z Stein L Mqoqi N Wabinga H Cancers Jamison DT Feachem RG Makgoba MW Bos ER Baingana FK Hofman KJ Rogo KO Disease and Mortality in Sub-Saharan Africa 2nd edition Washington (DC) World Bank 2006 Chapter 20

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Authors
Adeola, H. A., Blackburn, J. M., Rebbeck, T. R., & Zerbini, L. F.
Affiliations
  • University of Cape Town (ZA)
  • Harvard University (US)
Corresponding author
Zerbini, Luiz F.
Venue
Oncotarget
Published
2017-03-25
Volume
8
Issue
23
Pages
37991-38007
ISSN
1949-2553 (ISSN-L)
OpenAlex
W2603779982
Cited by
26
References
138
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3
FWCI
0.45
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • South African Medical Research Council
  • International Centre for Genetic Engineering and Biotechnology
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
  • Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords
prostate cancer, biomarker validation, African men, clinical implementation of biomarkers, translational research, prostate cancer diagnosis
MeSH terms
Africa, Humans, Male, Prostatic Neoplasms, Mass Spectrometry, Biomarkers, Proteomics

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