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Cited by 156Gut microbiota and healthRheumatoid Arthritis Research and TherapiesOral microbiology and periodontitis research

The Role of the Microbiome in Rheumatic Diseases

Yeoh, Nigel, Burton, Jeremy P., Suppiah, Praema, Reid, Gregor, Stebbings, Simon·2013·Current Rheumatology Reports
DOI 10.1007/s11926-012-0314-y
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Abstract

There is a growing understanding of the mechanisms by which the influence of the microbiota projects beyond sites of primary mucosal occupation to other human body systems. Bacteria present in the intestinal tract exert a profound effect on the host immune system, both locally and at distant sites. The oral cavity has its own characteristic microbiota, which concentrates in periodontal tissues and is in close association with a permeable epithelium. In this review we examine evidence which supports a role for the microbiome in the aetiology of rheumatic disease. We also discuss how changes in the composition of the microbiota, particularly within the gastrointestinal tract, may be affected by genetics, diet, and use of antimicrobial agents. Evidence is presented to support the theory that an altered microbiota is a factor in the initiation and perpetuation of inflammatory diseases, including rheumatoid arthritis (RA), spondyloarthritis (SpA), and inflammatory bowel disease (IBD). Mechanisms through which the microbiota may be involved in the pathogenesis of these diseases include altered epithelial and mucosal permeability, loss of immune tolerance to components of the indigenous microbiota, and trafficking of both activated immune cells and antigenic material to the joints. The potential to manipulate the microbiome, by application of probiotics and faecal microbial transplant (FMT), is now being investigated. Both approaches are in their infancy with regard to management of rheumatic disease but their potential is worthy of consideration, given the need for novel therapeutic approaches, and the emerging recognition of the importance of microbial interactions with human hosts.

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  • There is increasing evidence that dysbiosis in the intestinal microbial community could be related with some extra-intestinal pathologies, such as allergies, obesity and metabolic syndrome, rheumatic disease, and degenerative processes, among others.

    “Moreover, there is increasing evidence that dysbiosis in this microbial community could be related with some extra-intestinal pathologies, such as allergies, obesity and metabolic syndrome, rheumatic disease, and degenerative processes, among others [69][70][71] .”

    From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [70]

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Authors
Yeoh, N., Burton, J. P., Suppiah, P., Reid, G., & Stebbings, S.
Affiliations
  • University of Otago (NZ)
  • Western University (CA)
Corresponding author
Stebbings, Simon
ORCID
Venue
Current Rheumatology Reports
Publisher
Springer Science and Business Media LLC
Published
2013-02-03
Volume
15
Issue
3
Pages
314-314
ISSN
  • 1523-3774 (ISSN-L)
  • 1534-6307
DOI
10.1007/s11926-012-0314-y
OpenAlex
W2095223297
Cited by
155
References
135
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 14 · 2017: 8 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 7
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Rheumatology Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
microbiome, rheumatic diseases, rheumatoid arthritis, spondyloarthritis, inflammatory bowel disease, gut microbiota, oral microbiota, periodontal microbiota, mucosal permeability, immune tolerance, immune cell trafficking, probiotics, fecal microbiota transplantation, diet, antimicrobial agents, etiology
MeSH terms
Anti-Bacterial Agents, Diet, Humans, Immune Tolerance, Mouth, Obesity, Rheumatic Diseases, Probiotics, Gastrointestinal Tract, Metagenome

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