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Cited by 298

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Update on Atopic Dermatitis

Open access
Torres, Tiago, Ferreira, Eduarda Osório, Gonçalo, Margarida, Mendes-Bastos, Pedro, Selores, Manuela, Filipe, Paulo·2019·Acta Médica Portuguesa
DOI 10.20344/amp.11963
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Abstract

With an increasing prevalence during the past decades, atopic dermatitis has become a global health issue. A literature search following a targeted approach was undertaken to perform this non-systematic review, which intends to provide an overview of the epidemiology, pathophysiology, clinical features, comorbidities, and current therapies for the treatment of atopic dermatitis. In sum, this is a heterogeneous skin disorder associated with variable morphology, distribution, and disease course. Although not completely understood, its pathogenesis is complex and seems to result from a combination of genetic and environmental factors that induce skin barrier dysfunction, cutaneous and systemic immune dysregulation, skin microbiota dysbiosis, and a strong genetic influence. Diagnosis is based on specific criteria that consider patient and family history and clinical manifestations. Overall disease severity must be determined by evaluating both objective signs and subjective symptoms. Therapeutic goals require a multistep approach, focusing on reducing pruritus and establishing disease control. Patients should be advised on basic skin care and avoidance of triggers. Topical anti-inflammatory agents should be considered in disease flares or chronic/recurrent lesions. In case of inadequate response, phototherapy, systemic immunosuppressants and, more recently, dupilumab, should be added. Nevertheless, the treatment of moderate-to-severe atopic dermatitis remains challenging and novel, efficacious, safe and targeted treatments are urgently needed. In conclusion, although the last few years have seen important improvement in the understanding of the disease, future research in atopic dermatitis will continue exploring gene-environment interactions and how it affects pathophysiology, disease severity, and treatment outcomes.

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Metadata

Authors
Torres, T., Ferreira, E. O., Gonçalo, M., Mendes-Bastos, P., Selores, M., & Filipe, P.
Venue
Acta Médica Portuguesa
Publisher
Ordem dos Medicos
Published
2019-09-02
Volume
32
Issue
9
Pages
606-613
ISSN
  • 0870-399X (ISSN-L)
  • 1646-0758
DOI
10.20344/amp.11963
OpenAlex
W2972228782
Cited by
298
References
51
FWCI
20.56
Type
journal article
Language
en
Open access
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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