Cited by 796Infection Control in HealthcarePediatric health and respiratory diseasesInfection Control and Ventilation

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Effect of Hand Hygiene on Infectious Disease Risk in the Community Setting: A Meta-Analysis

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Aiello, Allison E., Coulborn, Rebecca M., Perez, Vanessa, Larson, Elaine L.·2008·American Journal of Public Health

DOI 10.2105/ajph.2007.124610PMC PMC2446461

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Abstract

To quantify the effect of hand-hygiene interventions on rates of gastrointestinal and respiratory illnesses and to identify interventions that provide the greatest efficacy, we searched 4 electronic databases for hand-hygiene trials published from January 1960 through May 2007 and conducted meta-analyses to generate pooled rate ratios across interventions (N=30 studies). Improvements in hand hygiene resulted in reductions in gastrointestinal illness of 31% (95% confidence intervals [CI]=19%, 42%) and reductions in respiratory illness of 21% (95% CI=5%, 34%). The most beneficial intervention was hand-hygiene education with use of nonantibacterial soap. Use of antibacterial soap showed little added benefit compared with use of nonantibacterial soap. Hand hygiene is clearly effective against gastrointestinal and, to a lesser extent, respiratory infections. Studies examining hygiene practices during respiratory illness and interventions targeting aerosol transmission are needed.

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Authors: Aiello, A. E., Coulborn, R. M., Perez, V., & Larson, E. L.
Affiliations: University of Michigan (US)
Allison E. Aiello, Rebecca M. Coulborn, and Vanessa Perez are with the Department of Epidemiology and Center for Social Epidemiology & Population Health, School of Public Health, University of Michigan, Ann Arbor. Elaine L. Larson is with the School of Nursing and the Mailman School of Public Health, Columbia University, New York, NY.
ORCID: Aiello, Allison E.
Coulborn, Rebecca M.
Larson, Elaine L.
Venue: American Journal of Public Health
Publisher: American Public Health Association
Published: 2008-08
Volume: 98
Issue: 8
Pages: 1372-1381
ISSN: 0090-0036 (ISSN-L)
1541-0048
DOI: 10.2105/ajph.2007.124610
PMC: PMC2446461
OpenAlex: W2109881331
Cited by: 796
References: 75
Citations by year: 2026: 21 · 2025: 44 · 2024: 49 · 2023: 57 · 2022: 78 · 2021: 91 · 2020: 83 · 2019: 40 · 2018: 39 · 2017: 40 · 2016: 31 · 2015: 48 · 2014: 36 · 2013: 39 · 2012: 31
FWCI: 2.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Public Health (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Michigan
Topics: Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric health and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
Keywords: hand hygiene, gastrointestinal diseases, respiratory diseases, infectious disease prevention, community settings, hand hygiene education, antibacterial soap, infection transmission
MeSH terms: Communicable Disease Control, Communicable Diseases, Gastrointestinal Diseases, Hand Disinfection, Humans, Respiratory Tract Infections, Surface-Active Agents, Databases, Bibliographic, Skin Care, Community-Acquired Infections, Risk Assessment

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Effect of Hand Hygiene on Infectious Disease Risk in the Community Setting: A Meta-Analysis

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