The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Critical Need for Family-Based, Quasi-Experimental Designs in Integrating Genetic and Social Science Research
Open accessAbstract
Researchers have identified environmental risks that predict subsequent psychological and medical problems. Based on these correlational findings, researchers have developed and tested complex developmental models and have examined biological moderating factors (e.g., gene-environment interactions). In this context, we stress the critical need for researchers to use family-based, quasi-experimental designs when trying to integrate genetic and social science research involving environmental variables because these designs rigorously examine causal inferences by testing competing hypotheses. We argue that sibling comparison, offspring of twins or siblings, in vitro fertilization designs, and other genetically informed approaches play a unique role in bridging gaps between basic biological and social science research. We use studies on maternal smoking during pregnancy to exemplify these principles.
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“A unique feature of this study is the use of the sibling-comparison design [25]. This has been adopted in previous Swedish studies [8,16] and allows one to account for unobserved familial (e.g., genetic and environmental) confounders.”
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“Under these assumptions, Model III isolated the residual effect of the association of interest, which is consistent with a causal inference [25].”
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Cites
(2002) · Cited by 13,211
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898
Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993) · PubMed · Cited by 3,679
How People Make Their Own Environments: A Theory of Genotype Environment Effects
Scarr, S., & McCartney, K. (1983) · Child Development · doi:10.1111/j.1467-8624.1983.tb03884.x · Cited by 2,895
(2009) · Cited by 2,013
Genotype-environment interaction and correlation in the analysis of human behavior.
Plomin, R., DeFries, J. C., & Loehlin, J. C. (1977) · Psychological Bulletin · doi:10.1037/0033-2909.84.2.309 · Cited by 1,685
Gene–environment interactions in psychiatry: joining forces with neuroscience
Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300
Coie, J. D., Watt, N. F., West, S. G., Hawkins, J. D., Asarnow, J. R., Markman, H. J., Ramey, S. L., Shure, M. B., & Long, B. (1993) · American Psychologist · doi:10.1037/0003-066x.48.10.1013 · Cited by 1,253
Coie, J. D., Watt, N. F., West, S. G., Hawkins, J. D., Asarnow, J. R., Markman, H. J., Ramey, S. L., Shure, M. B., & Long, B. (1993) · American Psychologist · doi:10.1037//0003-066x.48.10.1013 · Cited by 1,247
Research works printed but not linked: 11
- Barker DJP, 1998, Mothers, Babies and Health in Later Life
- Masten AS, 2010, Dev Psychopathol
- Kendler K, 2010, The Dynamic Genome and Mental Health: The Role of Genes and Environments in Development
- Plomin R, 2008, Behavioral Genetics
- Scarr S, 1983, Child Dev, 54, 424
- Turkheimer E, Handbook of Research Methods in Personality and Social Psychology
- 10.1375/twin.8.4.283 · DOI
- Spielman RS, 1993, Am J Hum Genet, 52, 506
- Baker P, 1989, NLSY Child Handbook
- Academy of Medical Sciences Working Group, 2007, Identifying the Environmental Causes of Disease: How Should We Decide What to Believe and When to Take Action?
- British Academy of Science Working Group, 2010, Social Science and Family Policy
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Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017) · Molecular Autism · doi:10.1186/s13229-017-0121-4 · Cited by 809
A hierarchical causal taxonomy of psychopathology across the life span.
Lahey, B. B., Krueger, R. F., Rathouz, P. J., Waldman, I. D., & Zald, D. H. (2017) · Psychological Bulletin · doi:10.1037/bul0000069 · Cited by 443
Self-citationHarold, G. T., & Sellers, R. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12893 · Cited by 383
Preterm Birth and Mortality and Morbidity
D'Onofrio, B. M., Class, Q. A., Rickert, M. E., Larsson, H., Långström, N., & Lichtenstein, P. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2107 · Cited by 300
Self-citationPaternal Age at Childbearing and Offspring Psychiatric and Academic Morbidity
D’Onofrio, B. M., Rickert, M. E., Frans, E., Kuja-Halkola, R., Almqvist, C., Sjölander, A., Larsson, H., & Lichtenstein, P. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4525 · Cited by 282
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Metadata
- Authors
- D’Onofrio, B. M., Lahey, B. B., Turkheimer, E., & Lichtenstein, P.
- Affiliations
- Brian M. D’Onofrio is with Indiana University, Bloomington. Benjamin B. Lahey is with the University of Chicago, Chicago, IL. Eric Turkheimer is with the University of Virginia, Charlottesville. Paul Lichtenstein is with the Karolinska Institutet, Solna, Sweden.
- Karolinska Institutet (SE)
- Venue
- American Journal of Public Health
- Publisher
- American Public Health Association
- Published
- 2013-10
- Volume
- 103
- Issue
- S1
- Pages
- S46-S55
- ISSN
- 0090-0036 (ISSN-L)
- 1541-0048
- PMC
- PMC3778076
- OpenAlex
- W2077233956
- Cited by
- 343
- References
- 114
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 20 · 2023: 15 · 2022: 29 · 2021: 29 · 2020: 29 · 2019: 32 · 2018: 27 · 2017: 36 · 2016: 31 · 2015: 24 · 2014: 26 · 2013: 10
- FWCI
- 20.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Public Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Vetenskapsrådet
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061817, R01HD061384, HD061384, HD061817)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Keywords
- genetically informed designs, family-based designs, quasi-experimental design, gene-environment interaction, environmental risk factors, causal inference, sibling comparison, in vitro fertilization, smoking during pregnancy
- MeSH terms
- Environmental Exposure, Family Health, Female, Humans, Pregnancy, Pregnancy Complications, Research Design, Risk Factors, Smoking, Social Sciences, Confounding Factors, Epidemiologic, Behavioral Research, Genetic Research, Gene-Environment Interaction
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