The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Does low socioeconomic status potentiate the effects of heightened cardiovascular responses to stress on the progression of carotid atherosclerosis?
Open accessAbstract
OBJECTIVES: This study examined whether heightened cardiovascular reactivity and low socioeconomic status had synergistic effects on the progression of carotid atherosclerosis in a population of eastern Finnish men. METHODS: Data from the Kuopio Ischemic Heart Disease Risk Factor Study were used to measure 4-year progression of intima-media thickness in 882 men according to cardiovascular reactivity and socioeconomic status. Associations were examined in relation to risk factors and were stratified by baseline levels of atherosclerosis and prevalent ischemic heart disease. RESULTS: The effect of reactivity on atherosclerotic progression depended on socioeconomic status. Men who had heightened cardiovascular responsiveness to stress and were born into poor families, received little education, or had low incomes had the greatest atherosclerotic progression. CONCLUSIONS: An understanding of associations between individual risk factors and disease should be based on etiologic hypotheses that are conceived at the population level and involve fundamental social and economic causes of disease. This study demonstrates how examining the interaction of an individual biological predisposition will low socioeconomic status over the life course is etiologically informative for understanding the progression of atherosclerotic vascular disease.
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“Current evidence, for example, suggests that lower SES may synergize with other stressors, potentiating the negative impact of “stressors” on accumulation of AL. 67,83,192,193”
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“For example, low SES has been found to synergize the effect of high cardiovascular reactivity on the progression of carotid atherosclerosis 46 and on ischemic stroke.”
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“SES has also been associated with the extent of CVD progression (7) and linked to risk factors for CVD, notably hypertension (8,9).”
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“Not only do individual differences in phasic stress reactivity lead to coronary artery disease, but the influence of these phasic events is potentiated by more global person-factors, such as socioeconomic status, and affective or psychopathologic syndromes, such as hostility and depression ( Lynch, Everson, Kaplan, Sa…”
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“The magnitude of one’s stress reaction is relevant for health, insofar as exaggerated stress responses contribute to hypertension and associated organ damage (Manuck et al., 1990) and to the progression of cardio-vascular disease (Lynch et al., 1998).”
Background
Metadata
- Authors
- Lynch, J. W., Everson, S. A., Kaplan, G. A., Salonen, R., & Salonen, J. T.
- Affiliations
- California Health and Human Services Agency (US)
- University of Eastern Finland (FI)
- Venue
- American Journal of Public Health
- Publisher
- American Public Health Association
- Published
- 1998-03
- Volume
- 88
- Issue
- 3
- Pages
- 389-394
- ISSN
- 0090-0036 (ISSN-L)
- 1541-0048
- PMC
- PMC1508331
- OpenAlex
- W1984088895
- Semantic Scholar
- d393df6b32d33b5bc1bec2fba2058ca5e11335f0
- Cited by
- 174
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 9
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Public Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-44199, R01HL044199)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- low socioeconomic status, cardiovascular reactivity, carotid atherosclerosis, atherosclerosis progression, intima-media thickness, stress response, social determinants of health, educational attainment, income, ischemic heart disease, men, life course
- MeSH terms
- Arteriosclerosis, Blood Pressure, Carotid Arteries, Carotid Artery Diseases, Educational Status, Exercise Test, Humans, Male, Middle Aged, Poverty, Risk Factors, Stress, Psychological, Disease Progression
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