Cited by 20Phonocardiography and Auscultation TechniquesCOVID-19 diagnosis using AIArtificial Intelligence in Healthcare

Uncertainty-Aware COVID-19 Detection from Imbalanced Sound Data

Open access
Xia, Tong, Han, Jing, Qendro, Lorena, Dang, Ting, Mascolo, Cecilia·2021·Interspeech 2021

Abstract

Recently, sound-based COVID-19 detection studies have shown great promise to achieve scalable and prompt digital prescreening.However, there are still two unsolved issues hindering the practice.First, collected datasets for model training are often imbalanced, with a considerably smaller proportion of users tested positive, making it harder to learn representative and robust features.Second, deep learning models are generally overconfident in their predictions.Clinically, false predictions aggravate healthcare costs.Estimation of the uncertainty of screening would aid this.To handle these issues, we propose an ensemble framework where multiple deep learning models for sound-based COVID-19 detection are developed from different but balanced subsets from original data.As such, data are utilized more effectively compared to traditional up-sampling and down-sampling approaches: an AUC of 0.74 with a sensitivity of 0.68 and a specificity of 0.69 is achieved.Simultaneously, we estimate uncertainty from the disagreement across multiple models.It is shown that false predictions often yield higher uncertainty, enabling us to suggest the users with certainty higher than a threshold to repeat the audio test on their phones or to take clinical tests if digital diagnosis still fails.This study paves the way for a more robust sound-based COVID-19 automated screening system.

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  • Uncertainty-aware modelling approaches enable prediction of uncertainty associated with final outcome predictions, providing confidence levels for users to trust or distrust systems.

    “Another potential solution for enhancing interpretability is adopting uncertainty-aware modelling approaches. These enable the prediction of uncertainty associated with the final outcome predictions, thereby providing confidence levels for users to either trust or distrust the systems.”
  • Ensemble learning for sound-based COVID-19 detection can infer uncertainty of model predictions, and false predictions often yield higher uncertainty, enabling suggestions to users with certainty higher than a threshold to repeat audio test or take clinical tests if digital diagnosis fails.

    “One study [185] employed ensemble learning for sound-based COVID-19 detection to infer the uncertainty of the model predictions and showed that false predictions often yield higher uncertainty, enabling us to suggest to users with certainty higher than a threshold to repeat the audio test on their phones or to take clinical tests if digital diagnosis still fails.”

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Research works printed but not linked: 3

  1. B. W. Schuller, D. M. Schuller, K. Qian, J. Liu, H. Zheng, and X. Li, "COVID-19 and computer audition: An overview on what speech & sound analysis could contribute in the sars-cov-2 corona crisis," Frontiers in Digital Health, vol. 3, pp. 1-10, 2021.
  2. A. Imran, I. Posokhova, H. N. Qureshi, U. Masood, M. S. Riaz, K. Ali, C. N. John, M. I. Hussain, and M. Nabeel, "Ai4COVID- 19: Ai enabled preliminary diagnosis for COVID-19 from cough samples via an app," Informatics in Medicine Unlocked, vol. 20, p. 100378, 2020.
  3. B. W. Schuller, S. Steidl, A. Batliner, P. B. Marschik, H. Baumeis- ter, F. Dong, S. Hantke, F. B. Pokorny, E.-M. Rathner, K. D. Bartl- Pokorny et al., "The 2018 computational paralinguistics chal- lenge: Atypical self-assessed affect, crying & heart beats." in Pro- ceedings of the INTERSPEECH, 2018, pp. 122-126.

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Authors
Xia, T., Han, J., Qendro, L., Dang, T., & Mascolo, C.
Affiliations
University of Cambridge (GB)
Venue
Interspeech 2021
Publisher
ISCA
Published
2021-08-30
Pages
2951-2955
ISSN
2308-457X (ISSN-L)
OpenAlex
W3196633546
Cited by
20
References
37
Citations by year
2025: 1 · 2024: 1 · 2023: 8 · 2022: 7 · 2021: 3
FWCI
17.19
Type
conference paper
Language
en
Open access
Locations
Interspeech (USB) (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Phonocardiography and Auscultation Techniques
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › COVID-19 diagnosis using AI
  • Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
Keywords
COVID-19 detection, class imbalance, uncertainty estimation, ensemble learning, model disagreement, overconfidence, false positive reduction

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