An Improved Huffman Coding Method for Archiving Text, Images, and Music Characters in DNA
Open accessAbstract
An improved Huffman coding method for information storage in DNA is described. The method entails the utilization of modified unambiguous base assignment that enables efficient coding of characters. A plasmid-based library with efficient and reliable information retrieval and assembly with uniquely designed primers is described. We illustrate our approach by synthesis of DNA that encodes text, images, and music, which could easily be retrieved by DNA sequencing using the specific primers. The method is simple and lends itself to automated information retrieval.
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Ailenberg and Rotstein (2009) encoded text, music, and images in DNA by using modified Huffman coding.
“Ailenberg and Rotstein (2009) encoded text, music, and images in DNA by using modified Huffman coding (Figure 3) [17].”
From DNA Data Storage. (2023) · cites this paper as [17]
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- Authors
- Ailenberg, M., & Rotstein, O. D.
- Affiliations
- St. Michael's Hospital (CA)
- ORCID
- Rotstein, Ori D.
- Venue
- BioTechniques
- Publisher
- Informa UK Limited
- Published
- 2009-09
- Volume
- 47
- Issue
- 3
- Pages
- 747-754
- ISSN
- 0736-6205 (ISSN-L)
- 1940-9818
- OpenAlex
- W2081311564
- Cited by
- 83
- References
- 10
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BioTechniques (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Canadian Institutes of Health Research (37779)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Physical Sciences › Computer Science › Artificial Intelligence › Algorithms and Data Compression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fractal and DNA sequence analysis
- Keywords
- DNA data storage, Huffman coding, plasmid library, primer design, DNA synthesis, text encoding, image compression, music encoding, automated information retrieval
- MeSH terms
- Amino Acid Sequence, Base Sequence, DNA, Molecular Sequence Data, Plasmids, Sequence Analysis, DNA, Computational Biology, Databases, Genetic
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