Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias
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Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias Stuart J Thomas, George T GrossbergDepartment of Neurology and Psychiatry, Saint Louis University School of Medicine, St. Louis, MO, USAAbstract: Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist with moderate affinity. Its mechanism of action is neuroprotective and potentially therapeutic in several neuropsychiatric diseases. It has been approved by the FDA for the treatment of moderate to severe Alzheimer’s disease (AD) either as a monotherapy or in combination with cholinesterase inhibitors. This review covers key studies of memantine’s safety and efficacy in treating moderate to severe AD. It also covers current research into other dementias including but not exclusively mild AD and vascular dementia. Other studies on the efficacy of memantine for other neuropsychiatric diseases are discussed. Memantine is a safe and effective drug that merits further research on several topics. Clinicians should be aware of new studies and potential uses of memantine because of its safety and efficacy.Keywords: memantine, Alzheimer’s disease, dementia
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Patients taking memantine experience adverse effects such as fatigue, pain, confusion, urinary incontinence, urinary tract infection and peripheral edema.
“Patients taking memantine experience adverse effects like fatigue, pain, confusion, urinary incontinence, urinary tract infection, peripheral edema, etc. [35].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [35]
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- [97]Grossberg GT Manes F Allegri R A multinational, randomized, double-blind, placebo-controlled, parallel-group trial of memantine extended-release capsule (28 mg, once daily) in patients with moderate to severe Alzheimer’s disease. [poster] 133rd Annual Meeting of the American Neurological Association September 21–24, 2008 Salt Lake City, UT, USA Clinical Interventions in Aging is an international, peer-reviewed journal focusing on evidence-based reports on the value or lack thereof of treatments intended to prevent or delay the onset of maladaptive correlates of aging in human beings This journal is indexed on PubMed Central, MedLine, the American Chemical Society’s ‘Chemical Abstracts Service’ (CAS), Scopus and the Elsevier Bibliographic databases. The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use. Visit http://www.dovepress.com/testimonials.php to read real quotes from published authors.
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Does mismatch negativity have utility for NMDA receptor drug development in depression?
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Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats
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Inflammation During Virus Infection: Swings and Roundabouts
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- Authors
- Grossberg, G., & Thomas, S.
- Affiliations
- Saint Louis University (US)
- Corresponding author
- Grossberg, George
- ORCID
- Grossberg, George
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2009-09
- Volume
- 4
- Pages
- 367
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC2762361
- OpenAlex
- W2008348302
- Cited by
- 151
- References
- 104
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 12 · 2018: 3 · 2017: 17 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 10 · 2012: 7
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- memantine, Alzheimer's disease, dementia, NMDA receptor antagonists, drug safety, drug efficacy, cholinesterase inhibitors, vascular dementia, mild Alzheimer's disease, neuroprotection, neuropsychiatric disorders
- MeSH terms
- Alzheimer Disease, Dementia, Humans, Memantine, Severity of Illness Index, Dopamine Agents, Treatment Outcome
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