The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mechanism linking diabetes mellitus and obesity
Open accessAbstract
Body mass index has a strong relationship to diabetes and insulin resistance. In obese individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is based on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes more inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Weight gain and body mass are central to the formation and rising incidence of type 1 and type 2 diabetes. This literature review will demonstrate the facts that link obesity with insulin resistance and pancreatic β-cell dysfunction. In conclusion, new approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on the facts.
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Cites
Mechanisms linking obesity to insulin resistance and type 2 diabetes
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Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339
“While the etiology of type 2 diabetes is multi-factorial, obesity is a primary risk factor as this state disrupts insulin homeostasis leading to abnormal blood glucose levels [32].”
BackgroundRole of medicinal plants in the management of diabetes mellitus: a review
Jacob, B., & Narendhirakannan, R. T. (2019) · 3 Biotech · doi:10.1007/s13205-018-1528-0 · Cited by 205
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Metadata
- Authors
- Algoblan, A., Alalfi, M., & Khan, M.
- Venue
- Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
- Publisher
- Informa UK Limited
- Published
- 2014-12
- Volume
- 7
- Pages
- 587
- ISSN
- 1178-7007 (ISSN-L)
- OpenAlex
- W2019141360
- Cited by
- 1,028
- References
- 10
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Algoblan, A., Alalfi, M., & Khan, M. (2014). Mechanism linking diabetes mellitus and obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. https://doi.org/10.2147/dmso.s67400
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
