Cited by 113Graphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers

Open access
Yan, Hongli, Xue, Zhifeng, Xie, Jiarong, Dong, Yixiao, Ma, Zhe, Sun, Xinru, Kebebe Borga, Dereje, Liu, Zhidong +1 more·2019·International Journal of Nanomedicine

Abstract

Nanoparticle drug formulations have enormous application prospects owing to achievement of targeted and sustained release drug delivery, improvement in drug solubility and reduction of adverse drug reactions. Recently, a variety of efficient drug nanometer carriers have been developed, among which carbon nanotubes (CNT) have been increasingly utilized in the field of cancer therapy. However, these nanotubes exert various toxic effects on the body due to their unique physical and chemical properties. CNT-induced toxicity is related to surface modification, degree of aggregation in vivo, and nanoparticle concentration. This review has focused on the potential toxic effects of CNTs utilized as anti-tumor drug carriers. The main modes by which CNTs enter target sites, the toxicity expressive types and the factors affecting toxicity are discussed.

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  1. [63]Kang B, Dai Y, Chang S, et al. Cell response to carbon nanotubes: size-dependent intracellular uptake mechanism and subcellular fate. Small. 2010; 6: 2362– 2366. doi: 10.1002/smll.201001260 20878638 · DOI
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Authors
Yan, H., Xue, Z., Xie, J., Dong, Y., Ma, Z., Sun, X., Kebebe Borga, D., Liu, Z., & Li, J.
Affiliations
Tianjin University of Traditional Chinese Medicine (CN)
Corresponding author
Liu, Zhidong
Venue
International Journal of Nanomedicine
Published
2019-12
Volume
Volume 14
Pages
10179-10194
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
OpenAlex
W2997737850
Cited by
113
References
198
Citations by year
2026: 11 · 2025: 18 · 2024: 25 · 2023: 17 · 2022: 18 · 2021: 19 · 2020: 4 · 2018: 1
FWCI
0.82
Type
journal article
Language
en
Open access
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
carbon nanotubes, nanoparticle toxicity, nanoparticle drug delivery, cancer therapy, surface modification, nanoparticle aggregation, toxicity factors, targeted drug delivery
MeSH terms
Animals, Antineoplastic Agents, Drug Carriers, Humans, Solubility, Nanotubes, Carbon

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