Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury
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Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense mechanisms, plays a major role in inducing oxidative damage and cellular impairment, resulting in a general decline of the physiological functions. The aim of this work was to evaluate age-related changes in circulating ROS levels and plasma protein carbonyls, in very young (2 months aged), young (8 months aged) and in middle age (15 months aged) F344 rats. In addition, the DNA oxidative marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) and the expression of the DNA repair enzymes APE1, OGG1 and UNG genes were also measured in the liver of these animals. We also determined whether systemic oxidative stress reflects oxidative injury at organ level. Our results demonstrate that the increase in circulating ROS and protein carbonyl content occurs as early as middle age. Moreover, increased 8-OHdG in the liver of 15-month-old rats was at least in part associated with a reduced DNA damage repairing capacity as suggested by the down-regulation of APE1 gene expression. In addition, we demonstrated for the first time, that plasma carbonyls and liver 8-OHdG are well correlated, suggesting that plasma protein carbonyls may be used as a surrogate marker of oxidative injury in target organs.
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Aging is associated with impaired activity of the proteasome and mitochondrial Lon proteases and reduced capacity for macromolecule repair.
“aging is associated with impaired activity of the proteasome and mitochondrial Lon proteases [203,204,205] and reduced capacity for macromolecule repair [201,202].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [201]
Progressive and irreversible oxidative damage accumulates with age and diminishes critical aspects of cell physiology.
“Progressive and irreversible oxidative damage accumulates with age and diminishes critical aspects of cell physiology [57,201,202].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [201]
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- Authors
- Luceri, C., Bigagli, E., Femia, A. P., Caderni, G., Giovannelli, L., & Lodovici, M.
- Affiliations
- University of Florence (IT)
- Corresponding author
- Lodovici, Maura
- ORCID
- Venue
- Toxicology Reports
- Publisher
- Elsevier BV
- Published
- 2018
- Volume
- 5
- Pages
- 141-145
- ISSN
- 2214-7500 (ISSN-L)
- PMC
- PMC5977162
- OpenAlex
- W2777437165
- Cited by
- 79
- References
- 33
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 17 · 2019: 9 · 2018: 5
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Toxicology Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Florence University of the Arts
- Ente Cassa di Risparmio di Firenze
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- aging, reactive oxygen species, protein carbonyls, oxidative stress, 8-hydroxy-2'-deoxyguanosine, DNA repair enzymes, APE1, OGG1, uracil-DNA glycosylase, oxidative damage biomarkers, F344 rats
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