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Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
Open accessAbstract
Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses.
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Cited by
Domingues, C., Santos, A., Alvarez-Lorenzo, C., Concheiro, A., Jarak, I., Veiga, F., Barbosa, I., Dourado, M., & Figueiras, A. (2022) · ACS Nano · doi:10.1021/acsnano.2c00128 · Cited by 235
In vitro assessment of silver nanoparticles immunotoxicity
Galbiati, V., Cornaghi, L., Gianazza, E., Potenza, M. A., Donetti, E., Marinovich, M., & Corsini, E. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.12.023 · Cited by 35
Metadata
- Authors
- Khang, D., Lee, Y. K., Choi, E.-J., Webster, T. J., & Kim, S.-H.
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2014-12
- Volume
- 10
- Pages
- 97
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W2090954511
- Cited by
- 244
- References
- 8
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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