Altered Function of Superior Parietal Lobule Associated with Perceptive Awareness in First-Episode Drug-Naïve Panic Disorders: A Preliminary fMRI Study
Open accessAbstract
BACKGROUND: Biased fear-related perception is one main characteristic in patients with panic disorder (PD) and their prominent cardiovascular symptoms associated with enhanced heartbeat perception. PATIENTS AND METHODS: We investigated interoceptive perception in 18 first-onset drug-naïve PD patients and 21 age- and gender-matched healthy controls (HC). Moreover, we compared blood oxygen level-dependent (BOLD) responses between the two groups during a heartbeat perception (interoception) task to assess task-evoked activity and its relationship with heartbeat perception scores (HPSs). RESULTS: We found that patients with PD compared to HCs revealed a trend higher but insignificant HPSs. Higher activity in the bilateral superior parietal lobule (SPL) was observed in PD patients compared to HCs during the perception of both heartbeats and pure tones compared to rest. Furthermore, patients with PD exhibited a significant positive correlation between BOLD activity in the left SPL during heartbeat > resting-state and HPS. CONCLUSION: Using a sample of first-episode drug-naïve patients, our study reports that patients with PD show altered activation in the bilateral SPL during both interoceptive and exteroceptive perception. The increased activation during interoceptive stimuli might render PD patients more engaged in processing information associated with their internal states.
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Jin et al. found increased activation in the bilateral superior parietal lobule in panic disorder compared with controls.
“Jin et al. assessed individuals with panic disorder and found increased activation in the bilateral superior parietal lobule in PD compared to controls [40].”
From Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis (2026) · cites this paper as [40]
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Cites
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · see citing works
Lamm, C., Decety, J., & Singer, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.014 · Cited by 2,016 · see citing works
Heart beat perception and emotional experience
Schandry, R. (1981) · Psychophysiology · doi:10.1111/j.1469-8986.1981.tb02486.x · Cited by 1,335 · see citing works
Uddin, L. Q., Clare Kelly, A. M., Biswal, B. B., Xavier Castellanos, F., & Milham, M. P. (2009) · Human Brain Mapping · doi:10.1002/hbm.20531 · Cited by 1,135 · see citing works
A modern learning theory perspective on the etiology of panic disorder.
Bouton, M. E., Mineka, S., & Barlow, D. H. (2001) · Psychological Review · doi:10.1037/0033-295x.108.1.4 · Cited by 1,017 · see citing works
Domschke, K., Stevens, S., Pfleiderer, B., & Gerlach, A. L. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.08.008 · Cited by 580 · see citing works
The neural correlates of direct and reflected self-knowledge
Ochsner, K. N., Beer, J. S., Robertson, E. R., Cooper, J. C., Gabrieli, J. D. E., Kihsltrom, J. F., & D'Esposito, M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.069 · Cited by 562 · see citing works
Towards a functional neuroanatomy of self-processing: effects of faces and words
Kircher, T. T. J., Senior, C., Phillips, M. L., Benson, P. J., Bullmore, E. T., Brammer, M., Simmons, A., Williams, S. C. R., Bartels, M., & David, A. S. (2000) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00036-7 · Cited by 403 · see citing works
Simmons, W. K., Avery, J. A., Barcalow, J. C., Bodurka, J., Drevets, W. C., & Bellgowan, P. (2013) · Human Brain Mapping · doi:10.1002/hbm.22113 · Cited by 401 · see citing works
Brain structures mediating cardiovascular arousal and interoceptive awareness
Pollatos, O., Schandry, R., Auer, D. P., & Kaufmann, C. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.026 · Cited by 351 · see citing works
Zamariola, G., Maurage, P., Luminet, O., & Corneille, O. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.06.006 · Cited by 287 · see citing works
Hoehn-Saric, R., McLeod, D. R., Funderburk, F., & Kowalski, P. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.913 · Cited by 217 · see citing works
How good are patients with panic disorder at perceiving their heartbeats?
Ehlers, A., & Breuer, P. (1996) · Biological Psychology · doi:10.1016/0301-0511(95)05153-8 · Cited by 205 · see citing works
A 1-year prospective study of panic attacks: Clinical course and factors associated with maintenance
Ehlers, A. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.164 · Cited by 199 · see citing works
The neural correlates of intentional and incidental self processing
Kircher, T. T. J., Brammer, M. J., Bullmore, E. T., Simmons, A., Bartels, M., & David, A. S. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(01)00138-5 · Cited by 194 · see citing works
Wiebking, C., Bauer, A., de GRECK, M., Duncan, N. W., Tempelmann, C., & Northoff, G. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903563794 · Cited by 159 · see citing works
Changes in interoceptive processes following brain stimulation
Pollatos, O., Herbert, B. M., Mai, S., & Kammer, T. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0016 · Cited by 134 · see citing works
Heartbeat perception and panic disorder: possible explanations for discrepant findings
Ehlers, A., Breuer, P., Dohn, D., & Fiegenbaum, W. (1995) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)e0002-z · Cited by 124 · see citing works
Internet-based treatment for panic disorder
Richards, J., Klein, B., & Carlbring, P. (2003) · Cognitive Behaviour Therapy · doi:10.1080/16506070302318 · Cited by 82 · see citing works
Wölk, J., Sütterlin, S., Koch, S., Vögele, C., & Schulz, S. M. (2014) · Brain and Behavior · doi:10.1002/brb3.206 · Cited by 44 · see citing works
Wiebking, C., & Northoff, G. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00589 · Cited by 41 · see citing works
Gruber, O., Melcher, T., Diekhof, E. K., Karch, S., Falkai, P., & Goschke, T. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2008.11.008 · Cited by 29 · see citing works
Neufang, S., Geiger, M. J., Homola, G. A., Mahr, M., Schiele, M. A., Gehrmann, A., Schmidt, B., Gajewska, A., Nowak, J., Meisenzahl‐Lechner, E., et al. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0945-8 · Cited by 26 · see citing works
Lai, C., & Wu, Y. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.08.006 · Cited by 24 · see citing works
Ballenger, J. C. (2006) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)70238-x · Cited by 19 · see citing works
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Zhou, S., Su, S., Hong, A., Yang, C. G., Liu, Q., Feng, W. S., & Wang, Z. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2038389 · Cited by 12 · see citing works
Gao, Z., Xiong, Z., Wang, X., Chang, Y., Kärkkäinen, T., & Cong, F. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.112039 · Cited by 3 · see citing works
Yan, H., Han, Y., Shan, X., Li, H., Liu, F., Li, P., Zhao, J., & Guo, W. (2023) · Biomedicines · doi:10.3390/biomedicines11092420 · Cited by 2 · see citing works
Self-citationBednarek, L., Harrison, B. J., Davey, C. G., Steward, T., & Jamieson, A. J. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02201-5 · Cited by 1 · see citing works
“Two studies examined interoception in anxiety disorders using the Critchley and Pollatos heartbeat task [ 39 , 40].”
Snell, L., Garner, M. J., Pfeifer, G., & Morriss, J. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121961 · Cited by 1 · see citing works
Zhuang, Q., Xu, C., Xu, N., Wang, T., Lock, M., & Chen, S. (2024) · medRxiv · doi:10.1101/2024.03.25.24304833
Gutzeit, J., Weiss, M. H., Kuhn, T., Klinger-König, J., Streit, F., Jockwitz, C., Brandes, B., Wright, M. N., Friedrich, C. M., Woeckel, M., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6627834/v1
Zhuang, Q., Xu, C., Xu, N., Feng, F., Lock, M., Chen, S., & Zang, Y. (2026) · Brain Imaging and Behavior · doi:10.1007/s11682-026-01071-8
Early Life Adversity, Brain Development and Behavioral OutcomesPreprint
Mitchell, O. W. H., Connaughton, M., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Brühl, R., Desrivières, S., Flor, H., Gowland, P. A., Grigis, A., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7345169
Mehrtabar, S., Ajdari, A., Azinfar, A., Karimi, E., Sarallah, R., Kahrizsangi, Z. E., Parsaei, M., Mohammadian, S. M., Gorjestani, O. R., Moghaddam, H. S., et al. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112334
Lester, R., Jones, A., & Gillespie, S. M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107061
- Authors
- Jin, H., Zhang, B., Cui, H., Li, W., Li, H., Hu, Q., Wang, J., & Li, C.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Guangzhou Medical University (CN)
- Corresponding author
- Li, Chunbo
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2020-07
- Volume
- Volume 16
- Pages
- 1653-1659
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC7340363
- OpenAlex
- W3040315112
- Cited by
- 10
- References
- 26
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Science and Technology Commission of Shanghai Municipality
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- panic disorder, superior parietal lobule, interoception, heartbeat perception, first-episode drug-naive patients, BOLD signal
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