Cited by 11Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychosomatic Disorders and Their TreatmentsHeart Rate Variability and Autonomic Control

Altered Function of Superior Parietal Lobule Associated with Perceptive Awareness in First-Episode Drug-Naïve Panic Disorders: A Preliminary fMRI Study

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Jin, Haiyan, Zhang, Bin, Cui, Huiru, Li, Wei, Li, Hui, Hu, Qiang, Wang, Jijun, Li, Chunbo·2020·Neuropsychiatric Disease and Treatment

Abstract

BACKGROUND: Biased fear-related perception is one main characteristic in patients with panic disorder (PD) and their prominent cardiovascular symptoms associated with enhanced heartbeat perception. PATIENTS AND METHODS: We investigated interoceptive perception in 18 first-onset drug-naïve PD patients and 21 age- and gender-matched healthy controls (HC). Moreover, we compared blood oxygen level-dependent (BOLD) responses between the two groups during a heartbeat perception (interoception) task to assess task-evoked activity and its relationship with heartbeat perception scores (HPSs). RESULTS: We found that patients with PD compared to HCs revealed a trend higher but insignificant HPSs. Higher activity in the bilateral superior parietal lobule (SPL) was observed in PD patients compared to HCs during the perception of both heartbeats and pure tones compared to rest. Furthermore, patients with PD exhibited a significant positive correlation between BOLD activity in the left SPL during heartbeat > resting-state and HPS. CONCLUSION: Using a sample of first-episode drug-naïve patients, our study reports that patients with PD show altered activation in the bilateral SPL during both interoceptive and exteroceptive perception. The increased activation during interoceptive stimuli might render PD patients more engaged in processing information associated with their internal states.

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Authors
Jin, H., Zhang, B., Cui, H., Li, W., Li, H., Hu, Q., Wang, J., & Li, C.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Guangzhou Medical University (CN)
Corresponding author
Li, Chunbo
Venue
Neuropsychiatric Disease and Treatment
Published
2020-07
Volume
Volume 16
Pages
1653-1659
ISSN
  • 1176-6328 (ISSN-L)
  • 1178-2021
OpenAlex
W3040315112
Cited by
10
References
26
Citations by year
2026: 5 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1
FWCI
0.48
Type
journal article
Language
en
Open access
Locations
  • Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Science and Technology Commission of Shanghai Municipality
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
panic disorder, superior parietal lobule, interoception, heartbeat perception, first-episode drug-naive patients, BOLD signal

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