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Cited by 45Dementia and Cognitive Impairment ResearchAging, Health, and DisabilityTreatment of Major Depression

Late- versus early-onset geriatric depression in a memory research center

Open access
Dillon, Carol·2009·Neuropsychiatric Disease and Treatment
DOI 10.2147/ndt.s7320PMC PMC2762368
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Abstract

OBJECTIVE: To contrast early-onset (<60 years) and late-onset (>60 years) depression in geriatric patients by evaluating differences in cognition, vascular comorbidity and sociological risk factors. Both patient groups were compared with normal subjects. MATERIALS AND METHODS: We recruited 76 patients with depressive symptoms (37 late onset and 39 early onset) and 17 normal controls matched by age and educational level. All subjects were assessed using a semistructured neuropsychiatric interview and an extensive neuropsychological battery. Vascular and sociological risk factors were also evaluated. RESULTS: We found a significant variation in performance between depressive patients and normal controls in most cognitive functions, especially memory (P < 0.0001), semantic fluency (P < 0.0001), verbal fluency, and digit-symbol (P < 0.0001). Late-onset depression patients scored lower and exhibited more severe impairment in memory domains than early-onset depression patients (P < 0.05). Cholesterol levels and marital status were significantly (P < 0.05) different between the depressive groups. Both depressed groups (early- and late-onset) were more inactive than controls (P < 0.05; odds ratio: 6.02). CONCLUSION: Geriatric depression may be a manifestation of brain degeneration, and the initial symptom of a dementia. It is important to consider this in the treatment of patients that exhibit late-onset depressive symptoms.

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  • Individuals with late-onset late-life depression exhibit greater cognitive impairment compared to those with first onset earlier in life.

    “LLD is consistently associated with greater WMH severity229,230, and individuals with late onset exhibit greater WMH severity220,231–234 and greater cognitive impairment234–236 compared to those with first onset earlier in life.”

    From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [235]

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Research works printed but not linked: 2

  1. [24]Signoret JL Batterie d’efficience mnesique Paris, France Editions Scientifiques, Elsevier 1991
  2. [26]Freedman M Learch K Kaplan E Winocur G Shulman KI Delis D Clock Drawing: SA Neuropsychological Analysis New York, NY Oxford University Press 1994

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Authors
Dillon, C.
Affiliations
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (AR)
Corresponding author
Dillon, Carol
Venue
Neuropsychiatric Disease and Treatment
Publisher
Informa UK Limited
Published
2009-10
Volume
5
Pages
517
ISSN
1176-6328 (ISSN-L)
DOI
10.2147/ndt.s7320
PMC
PMC2762368
OpenAlex
W2149465433
Cited by
45
References
67
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 9 · 2013: 1 · 2012: 4
FWCI
2.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
Consejo Nacional de Investigaciones Científicas y Técnicas
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
geriatric depression, late-onset depression, early-onset depression, cognitive impairment, memory impairment, vascular comorbidities, cholesterol, marital status, physical inactivity, dementia, semantic fluency, verbal fluency, digit symbol test

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