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Actigraphy-based sleep estimation in adolescents and adults: a comparison with polysomnography using two scoring algorithms
Open accessAbstract
Objectives: Actigraphy is widely used to estimate sleep–wake time, despite limited information regarding the comparability of different devices and algorithms. We compared estimates of sleep–wake times determined by two wrist actigraphs (GT3X+ versus Actiwatch Spectrum [AWS]) to in-home polysomnography (PSG), using two algorithms (Sadeh and Cole–Kripke) for the GT3X+ recordings. Subjects and methods: Participants included a sample of 35 healthy volunteers (13 school children and 22 adults, 46% male) from Boston, MA, USA. Twenty-two adults wore the GT3X+ and AWS simultaneously for at least five consecutive days and nights. In addition, actigraphy and PSG were concurrently measured in 12 of these adults and another 13 children over a single night. We used intraclass correlation coefficients (ICCs), epoch-by-epoch comparisons, paired t -tests, and Bland–Altman plots to determine the level of agreement between actigraphy and PSG, and differences between devices and algorithms. Results: Each actigraph showed comparable accuracy (0.81–0.86) for sleep–wake estimation compared to PSG. When analyzing data from the GT3X+, the Cole–Kripke algorithm was more sensitive (0.88–0.96) to detect sleep, but less specific (0.35–0.64) to detect wake than the Sadeh algorithm (sensitivity: 0.82–0.91, specificity: 0.47–0.68). Total sleep time measured using the GT3X+ with both algorithms was similar to that obtained by PSG (ICC=0.64–0.88). In contrast, agreement between the GT3X+ and PSG wake after sleep onset was poor (ICC=0.00–0.10). In adults, the GT3X+ using the Cole–Kripke algorithm provided data comparable to the AWS (mean bias=3.7±19.7 minutes for total sleep time and 8.0±14.2 minutes for wake after sleep onset). Conclusion: The two actigraphs provided comparable and accurate data compared to PSG, although both poorly identified wake episodes (i.e., had low specificity). Use of actigraphy scoring algorithm influenced the mean bias and level of agreement in sleep–wake times estimates. The GT3X+, when analyzed by the Cole–Kripke, but not the Sadeh algorithm, provided comparable data to the AWS. Keywords: validation, actigraphy, polysomnography, scoring algorithm
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“Another research study for in-home polysomnography (PSG) using the Cole–Kripke algorithm on a sample of 35 healthy volunteers found that it was more sensitive to identify sleep (88–96%), but less specific to detect awake time (35–64%) [195].”
From Review of Wearable Devices and Data Collection Considerations for Connected Health (2021) · cites this paper as [195]
In the citing paper
“Previous research indicates that this algorithm undervalued sleep and exaggerated wakefulness in children and vice versa in adults.”
From Review of Wearable Devices and Data Collection Considerations for Connected Health (2021) · cites this paper as [195]
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“However, research suggests that [195] Cole–Kripke sleep misclassification was high in research involving children as compared to adults.”
From Review of Wearable Devices and Data Collection Considerations for Connected Health (2021) · cites this paper as [195]
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Johnson, D. A., Javaheri, S., Guo, N., Champion, C., Sims, J. F., Brock, M. P., Sims, M., Patel, S. R., Williams, D. R., Wilson, J. G., et al. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000778 · Cited by 20
Self-citationSleep Disturbances, Changes in Sleep, and Cognitive Function in Low-Income African Americans
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Campbell, E., Poudevigne, M. S., McFarlane, S., Dilworth, L., & Irving, R. R. (2021) · Journal of Sports Medicine · doi:10.1155/2021/6694547 · Cited by 18
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Holzhausen, E. A., Malecki, K. M. C., Sethi, A. K., Gangnon, R. E., Cadmus‐Bertram, L., Deblois, C. L., Suen, G., Safdar, N., & Peppard, P. E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276684 · Cited by 18
Emerging applications of objective sleep assessments towards the improved management of insomnia
Scott, H., Lechat, B., Manners, J., Lovato, N., Vakulin, A., CATCHESIDE, P. G., Eckert, D. J., & Reynolds, A. C. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.10.030 · Cited by 17
Abdollahi, A. M., Li, X., Merikanto, I., Leppänen, M. H., Vepsäläinen, H., Lehto, R., Ray, C., Erkkola, M., & Roos, E. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13960 · Cited by 19
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Using New Technologies and Wearables for Characterizing Sleep in Population-based Studies
Jaiswal, S. J., Pawelek, J., Warshawsky, S., Quer, G., Trieu, M., Pandit, J. A., & Owens, R. L. (2024) · Current Sleep Medicine Reports · doi:10.1007/s40675-023-00272-7 · Cited by 16
Sleep in Offspring of Parents With Mood Disorders
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Gasperetti, C. E., Dolsen, E. A., & Harvey, A. G. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.11.014 · Cited by 16
Sleep problems in children with Angelman Syndrome: The effect of a behavioral intervention program
Heus, K. B., Radstaake, M., Legerstee, J. S., ten Hoopen, L. W., Dieleman, G. C., Moll, H. A., Mous, S. E., & de Wit, M. Y. (2023) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2023.104444 · Cited by 16
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The impact of sleep loss on sustained and transient attention: an EEG study
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Sleep duration and physical performance during a 6‐week military training course
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A clinical-translational review of sleep problems in neurodevelopmental disabilities
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Sleep-Wake Disturbances and Episodic Memory in Older Adults
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Hormone-sleep interactions predict cerebellar connectivity and behavior in aging females
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Metadata
- Authors
- Quante, M., Kaplan, E. R., Cailler, M., Rueschman, M., Wang, R., Weng, J., Taveras, E. M., & Redline, S.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Quante, Mirja
- Venue
- Nature and Science of Sleep
- Publisher
- Informa UK Limited
- Published
- 2018-01
- Volume
- Volume 10
- Pages
- 13-20
- ISSN
- 1179-1608 (ISSN-L)
- PMC
- PMC5779275
- OpenAlex
- W2783706351
- Cited by
- 298
- References
- 22
- Citations by year
- 2026: 35 · 2025: 27 · 2024: 53 · 2023: 41 · 2022: 42 · 2021: 41 · 2020: 31 · 2019: 19 · 2018: 8
- FWCI
- 32.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature and Science of Sleep (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Max Kade Foundation
- National Cancer Institute (U54CA155626)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- actigraphy, polysomnography, total sleep time, wake after sleep onset, adolescents, adults, device agreement, home sleep monitoring
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